Results 1 to 10 of about 49,263 (157)

Basic and Translational Research on Proteinase-Activated Receptors: Implication of Proteinase/Proteinase-Activated Receptor in Gastrointestinal Inflammation

Journal of Pharmacological Sciences, 2008
Recently, the role of serine proteinases in the pathogenesis of inflammation and autoimmune diseases via interaction with the proteinase-activated receptor (PAR) has attracted attention.
Norimasa Yoshida, Toshikazu Yoshikawa
doaj   +6 more sources

Basic and Translational Research on Proteinase-Activated Receptors: Proteinase-Activated Receptors in Female Reproductive Tissues and Endometriosis

Journal of Pharmacological Sciences, 2008
During the menstrual cycle, dynamic morphological changes are observed in the ovarian follicle and the endometrium. These changes are associated with the onset of the inflammatory response in which many proteinases play various roles.
Yutaka Osuga, Yasushi Hirota, Yuji Taketani   +2 more
doaj   +4 more sources

Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2 [PDF]

Nature Communications
Members of the proteinase-activated receptor (PAR) subfamily of G protein-coupled receptors (GPCRs) play critical roles in processes like hemostasis, thrombosis, development, wound healing, inflammation, and cancer progression.
Zongyang Lyu, Xiaoxuan Lyu, Andrey G. Malyutin, Guliang Xia, Daniel Carney, Vinicius M. Alves, Matthew Falk, Nidhi Arora, Hua Zou, Aaron P. McGrath, Yanyong Kang   +10 more
doaj   +2 more sources

Novel Role for Proteinase-activated Receptor 2 (PAR2) in Membrane Trafficking of Proteinase-activated Receptor 4 (PAR4) [PDF]

Journal of Biological Chemistry, 2012
Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh supply of receptor is required to be mobilized to the cell surface for responsiveness to agonist to
Margaret R Cunningham, Kathryn Mcintosh, John D Pediani   +2 more
exaly   +6 more sources

Some aspects of trypsin’s involvement in the regulation of physiological functions [PDF]

Frontiers in Molecular Biosciences
I. V. Kuzmina, S. M. Tolpygo, V. G. Vertiprakhov   +2 more
doaj   +2 more sources

Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors. [PDF]

PLoS ONE, 2011
Implantation S1 family serine proteinases (ISPs) are tryptases involved in embryo hatching and uterine implantation in the mouse. The two different ISP proteins (ISP1 and ISP2) have been detected in both pre- and post-implantation embryo tissue. To date,
Navneet Sharma, Rajeev Kumar, Bernard Renaux, Mahmoud Saifeddine, Sandra Nishikawa, Koichiro Mihara, Rithwik Ramachandran, Morley D Hollenberg, Derrick E Rancourt   +8 more
doaj   +1 more source

Proteinase Activated Receptors Mediate the Trypsin-Induced Ca2 + Signaling in Human Uterine Epithelial Cells

Frontiers in Cell and Developmental Biology, 2021
Embryo implantation is a complex and tightly regulated process. In humans, uterine luminal epithelium functions as a biosensor gauging the embryo quality and transmitting this information to the underlying endometrial stromal cells.
Anatoliy Shmygol, Jan J. Brosens, Jan J. Brosens   +2 more
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PARs in the Respiratory System: Cellular Signaling and Physiological/Pathological Roles

Journal of Pharmacological Sciences, 2005
Proteinase-activated receptors (PARs), a family of G protein-coupled receptors, are widely distributed in the mammalian body, playing a variety of physiological/pathophysiological roles. In the respiratory systems, PARs, particularly PAR-2 and PAR-1, are
Kawabata Atsufumi, Naoyuki Kawao
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Regulation of the Expression of PARs

Journal of Pharmacological Sciences, 2005
The level of receptors expressed on the cell surface determines the cellular responsiveness to agonists. Proteinase-activated receptors (PARs) have been reported to be either upregulated or down-regulated in response to various types of stimulation and ...
Katsuya Hirano, Tatsuya Yufu, Mayumi Hirano, Junji Nishimura, Hideo Kanaide   +4 more
doaj   +1 more source

Epithelial effects of proteinase-activated receptors in the gastrointestinal tract

Memorias do Instituto Oswaldo Cruz, 2005
The intestinal epithelium plays a crucial role in providing a barrier between the external environment and the internal milieu of the body. A compromised mucosal barrier is characteristic of mucosal inflammation and is a key determinant of the ...
Wallace K MacNaughton
doaj   +1 more source