Results 1 to 10 of about 53,694 (118)

Solitary chemosensory cells amplify eosinophilic inflammation via PAR-2 activation in house dust mite-sensitized allergic rhinitis [PDF]

World Allergy Organization Journal
Background: Recent studies have shown that solitary chemosensory cells (SCCs) are rare nasal epithelial cells effectively responding to pathogens and are the predominant epithelial sources of IL-25. We investigated the roles of SCCs in nasal eosinophilic
Pei Gao, MD, Liyue Li, PhD, Yan Zou, MD, Jianxin Yue, PhD, Tao Zhou, PhD, Liuqing Zhou, PhD, Yue Zhou, PhD, Shan Chen, PhD, Yanyan Ding, MD, Han Wu, PhD, Qing Cheng, PhD, Yanjun Wang, PhD, Jianjun Chen, PhD, Hongjun Xiao, PhD   +13 more
doaj   +2 more sources

Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins [PDF]

Nature Communications
Insulin/insulin-like growth factor signaling inhibits FOXO transcription factors to control development, homeostasis, and aging. Here, we use proximity labeling to identify proteins interacting with the C. elegans FOXO DAF-16.
Murat Artan, Hanna Schoen, Mario de Bono
doaj   +2 more sources

Proteolytic activity of Triatoma infestans saliva associated with PAR-2 activation and vasodilation [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Triatoma infestans (Hemiptera: Reduviidae) is a hematophagous insect and the main vector of Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). In the present study, the authors investigated whether a serine protease activity from the saliva
Karla A. Oliveira, Ricardo J. S. Torquato, Daniela C. G. Garcia Lustosa, Tales Ribeiro, Bruno W. L. Nascimento, Lilian C. G. de Oliveira, Maria A. Juliano, Thaysa Paschoalin, Virginia S. Lemos, Ricardo N. Araujo, Marcos H. Pereira, Aparecida S. Tanaka   +11 more
doaj   +1 more source

Nociceptive Sensitization by Activation of Protease-Activated Receptor 2 in a Rat Model of Incisional Pain

Brain Sciences, 2021
Postoperative pain and consequent inflammatory responses after tissue incision adversely affects many surgical patients due to complicated mechanisms.
Kanta Kido, Norika Katagiri, Hiromasa Kawana, Shigekazu Sugino, Masanori Yamauchi, Eiji Masaki   +5 more
doaj   +1 more source

Phellodendron amurense Extract Protects Human Keratinocytes from PM2.5-Induced Inflammation via PAR-2 Signaling

Biomolecules, 2020
Dietary supplement and personal care products aiming to provide protection from air pollution have been of great interest for decades. Epidemiology demonstrated that PM10 and PM2.5 particulate matter (PM) are an actual threat to public health worldwide ...
Jiyoung Choi, Mi Yeon Moon, Gi Yeon Han, Moon Sik Chang, Dongki Yang, Joonseok Cha   +5 more
doaj   +1 more source

Optical biosensor differentiates signaling of endogenous PAR₁ and PAR₂ in A431 cells

BMC Cell Biology, 2007
Background Protease activated receptors (PARs) consist of a family of four G protein-coupled receptors. Many types of cells express several PARs, whose physiological significance is mostly unknown.
Ferrie Ann M, Fang Ye
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2-Mediated Proliferation of Colon Cancer Cell

Journal of Pharmacological Sciences, 2005
Proteinase-activated receptor-2 (PAR-2) has been demonstrated to be highly expressed in the gastrointestinal tract. In the present minireview, we summarize the effects of PAR-1 and PAR-2 stimulation using their activating peptides and agonist proteinases
Masahiro Nishibori, Shuji Mori, Hideo K. Takahashi   +2 more
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

Journal of Pharmacological Sciences, 2005
PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases. In order to evaluate the therapeutic potential for PAR-2, we have performed studies on PAR-2-mediated signal ...
Toru Kanke, Toshiaki Takizawa, Mototsugu Kabeya, Atsufumi Kawabata   +3 more
doaj   +1 more source

Evaluating the potential of Vitamin D and curcumin to alleviate inflammation and mitigate the progression of osteoarthritis through their effects on human chondrocytes: A proof-of-concept investigation.

PLoS ONE, 2023
Osteoarthritis (OA) is a chronic degenerative joint disorder primarily affecting the elderly, characterized by a prominent inflammatory component. The long-term side effects associated with current therapeutic approaches necessitate the development of ...
Rajashree Patnaik, Sumbal Riaz, Bala Mohan Sivani, Shemima Faisal, Nerissa Naidoo, Manfredi Rizzo, Yajnavalka Banerjee   +6 more
doaj   +1 more source

Thrombin-Stimulated Proliferation of Cultured Human Synovial Fibroblasts Through Proteolytic Activation of Proteinase-Activated Receptor-1

Journal of Pharmacological Sciences, 2008
We examined the mechanism of thrombin on proliferation of synovial fibroblasts obtained from rheumatoid arthritis (RA). Thrombin concentration-dependently induced proliferation of synovial fibroblasts. Proliferation in response to thrombin (10 U /ml) was
Ikue Furuhashi, Kazuki Abe, Toshitsugu Sato, Hideo Inoue   +3 more
doaj   +1 more source