Update on protease-activated receptor 2 in inflammatory and autoimmune dermatological diseases [PDF]
Frontiers in ImmunologyProtease-activated receptor 2 (PAR2) is a cell-surface receptor expressed in various cell types, including keratinocytes, neurons, immune and inflammatory cells.
Kejia Xu +6 more
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The Many Faces of Protease-Activated Receptor 2 in Kidney Injury [PDF]
BiomedicinesProtease-activated receptor 2 (PAR2) is a seven-transmembrane, G-protein-coupled receptor that is activated by coagulation proteases such as factor VIIa and factor Xa and other serine proteases.
Yuji Oe +2 more
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Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives [PDF]
Frontiers in ImmunologyProtease-activated receptor-2 (PAR2) is a class-A G protein-coupled receptor (GPCR) activated by serine proteases and is expressed by multiple tissues, including the skin.
Mengjie Fan +7 more
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Protease activated receptor-2 contributes to heart failure. [PDF]
PLoS ONE, 2013 Heart failure is a major clinical problem worldwide. Previous studies have demonstrated an important role for G protein-coupled receptors, including protease-activated receptors (PARs), in the pathology of heart hypertrophy and failure. Activation of PAR-
Silvio Antoniak +5 more
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Neuroprotection induced by protease-activated receptor 2 activation is independent of Gq signalling [PDF]
Brain and Neuroscience AdvancesProtease-activated receptor 2 is proposed to be a novel target for several inflammation-related diseases but its role in the central nervous system remains unclear.
Serge Moudio +2 more
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Structural basis of protease-activated receptor 2 activation and biased agonism [PDF]
Cell DiscoveryProtease-activated receptor 2 (PAR2) is a transmembrane receptor that is irreversibly activated by proteolytic cleavage of its N-terminus via extracellular proteases, resulting in the release of the tethered ligand (TL), which binds to and activates the ...
Xinyan Zhu +5 more
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Modulation of Intestinal Epithelial Permeability via Protease-Activated Receptor-2-Induced Autophagy [PDF]
Cells, 2022 Protease-activated receptor 2 (PAR2) alleviates intestinal inflammation by upregulating autophagy. PAR2 also modulates tight junctions through β-arrestin signaling.
Yuju Kim +7 more
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1-Piperidine Propionic Acid as an Allosteric Inhibitor of Protease Activated Receptor-2 [PDF]
Pharmaceuticals, 2023 In the last decades, studies on the inflammatory signaling pathways in multiple pathological contexts have revealed new targets for novel therapies. Among the family of G-protein-coupled Proteases Activated Receptors, PAR2 was identified as a driver of ...
Monica Chinellato +8 more
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Inhibition of Protease Activated Receptor 2 Attenuates HBx-Induced Inflammation and Mitochondria Oxidative Stress [PDF]
Infection and Drug Resistance, 2022 Bin Li,1 Yonggang Li,2 Shuhua Li,1 Hongwei Li,1 Ling Liu,1 Yao Xu3 1Laboratory of Immunology and Pathogenic Biology, Experimental Teaching Center of Basic Medicine, Jinzhou Medical University, Jinzhou City, Liaoning Province, 121001, People’s Republic of
Li B, Li Y, Li S, Li H, Liu L, Xu Y
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Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury [PDF]
Mediators of Inflammation, 2023 Interstitial inflammation is an important mechanism of pathological damage in renal injury caused by hyperuricemia. Protease-activated receptor-2 (PAR2) is a class of targets that act upstream of the PI3K/AKT/NF-κB pathway and is involved in various ...
Xiaolu Sui +8 more
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