Results 31 to 40 of about 313,816 (251)
Mucosal sensitization to German cockroach involves protease-activated receptor-2
Respiratory Research, 2010 Background Allergic asthma is on the rise in developed countries. A common characteristic of allergens is that they contain intrinsic protease activity, and many have been shown to activate protease-activated receptor (PAR)-2 in vitro. The role for PAR-2
Dienger Krista +4 more
doaj +1 more source
Protease-activated receptor 2 mediates mucus secretion in the airway submucosal gland. [PDF]
PLoS ONE, 2012 Protease-activated receptor 2 (PAR2), a G protein-coupled receptor expressed in airway epithelia and smooth muscle, plays an important role in airway inflammation.
Hyun Jae Lee +6 more
doaj +1 more source
Activation of protease-activated receptor 2 induces VEGF independently of HIF-1. [PDF]
PLoS ONE, 2012 BackgroundHuman adipose stem cells (hASCs) can promote angiogenesis through secretion of proangiogenic factors such as vascular endothelial growth factor (VEGF).
Jeppe Grøndahl Rasmussen +7 more
doaj +1 more source
Role of Protease-Activated Receptor 2 in Regulating Focal Segmental Glomerulosclerosis
Cellular Physiology and Biochemistry, 2017 Background /Aims: The underlying mechanisms leading to focal segmental glomerulosclerosis (FSGS) are lacking. In this report, we examined the role of protease-activated receptors (PARs) subtype PAR2 and its downstream signals in regulating the ...
Yongjun Wang +5 more
doaj +1 more source
Expression of protease‐activated receptor‐1 and ‐2 in orofacial granulomatosis [PDF]
Oral Diseases, 2007 Objective: Orofacial granulomatosis (OFG) is a rare condition characterized by non‐caseating granulomas in the orofacial region. Protease‐Activated Receptors (PARs) play a role in inflammatory diseases in diverse human tissues. The aim of the study was to investigate the expression of PAR‐1, PAR‐2, MMP‐2, MMP‐9, COX‐1, and COX‐2 in tissues taken from ...
S. Ketabchi +12 more
openaire +4 more sources
Protease-activated Receptor 2 mRNA Expression in Experimentally Induced Clinical Mastitis in Does
International Journal of Infectious Diseases, 2022 Purpose: Protease-activated receptor 2 (PAR2) is one of the G protein-coupled receptors that plays important roles during inflammation. Inflammatory stimuli could activate PAR2 which subsequently regulates a set of crucial biological processes involved ...
M.Z. Sukiman +5 more
doaj +1 more source
Physiological functions of protease-activated receptor-2.
Folia Pharmacologica Japonica, 2003 Protease-activated receptors (PARs) are a family of G-protein-coupled-seven-trans-membrane-domain-receptors activated by specific proteases, consisting of four family members. PAR-2, a receptor activated by trypsin, tryptase or coagulation factors VIIa and Xa, is unevenly distributed throughout the mammalian body, modulating multiple physiological ...
openaire +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization
International Journal of Cell Biology, 2017 The serine protease thrombin activates Protease-Activated Receptors (PARs), a family of G-protein-coupled receptors (GPCRs) activated by the proteolytic cleavage of their extracellular N-terminal domain.
Alejandro Alvarez-Arce +4 more
doaj +1 more source