Protective role of protease-activated receptor-2 in anaphylaxis model mice. [PDF]
PLoS ONEAnaphylaxis is a severe life-threatening hypersensitivity reaction induced by mast cell degranulation. Among the various mediators of mast cells, little is known about the role of tryptase. Therefore, we aimed to elucidate the role of protease-activating
Maho Nakazawa +6 more
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The Role of Protease-Activated Receptor 2 in Hepatocellular Carcinoma after Hepatectomy [PDF]
Medicina, 2021 Background and Objectives: Protease activated receptor-2 (PAR2) is elevated in a variety of cancers and has been promoted as a potential therapeutic target.
Ming-Chao Tsai +9 more
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Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice [PDF]
Frontiers in Immunology, 2021 BackgroundInnate immune responses to influenza A virus (IAV) infection are initiated in part by toll-like receptor 3 (TLR3). TLR3-dependent signaling induces an antiviral immune response and an NFκB-dependent inflammatory response.
Randall C. Gunther +12 more
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Role of trypsin and protease-activated receptor-2 in ovarian cancer.
PLoS ONE, 2020 Proteases have been implicated in the tumorigenesis and aggressiveness of a variety of cancer types. In fact, proteases have proven to be very clinically useful as tumor biomarkers in the blood of patients.
Kyu Kwang Kim +6 more
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PARting Neuroinflammation with Protease-Activated Receptor 2 Pepducins. [PDF]
J Pharmacol Exp TherScarisbrick IA.
europepmc +3 more sources
Biomolecules, 2022 Plasminogen and its multiple receptors have been implicated in the responses of many different cell types. Among these receptors, histone 2B (H2B) has been shown to play a prominent role in macrophage responses.
Mitali Das +2 more
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Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2. [PDF]
PLoS ONE, 2014 Acanthamoeba is a free-living amoeba commonly present in the environment and often found in human airway cavities. Acanthamoeba possesses strong proteases that can elicit allergic airway inflammation.
Mi Kyung Park +5 more
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Protease-Activated Receptor-2 Modulates Protease-Activated Receptor-1–Driven Neointimal Hyperplasia [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2011 Objective—Emerging evidence suggests that protease-activated receptors-1 and -2 (PAR1 and PAR2) can signal together in response to proteases found in the rapidly changing microenvironment of damaged blood vessels. However, it is unknown whether PAR1 and PAR2 promote or mitigate the hyperplastic response to arterial injury.
Leila M, Sevigny +7 more
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Potent Small Agonists of Protease Activated Receptor 2 [PDF]
ACS Medicinal Chemistry Letters, 2015 Many proteases cut the PAR2 N-terminus resulting in conformational changes that activate cells. Synthetic peptides corresponding to newly exposed N-terminal sequences of PAR2 also activate the receptor at micromolar concentrations. PAR2-selective small molecules reported here induce PAR2-mediated intracellular calcium signaling at nanomolar ...
Yau, Mei-Kwan +9 more
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Expression of protease-activated receptor 1 and 2 and anti-tubulogenic activity of protease-activated receptor 1 in human endothelial colony-forming cells. [PDF]
PLoS ONE, 2014 Endothelial colony-forming cells (ECFCs) are obtained from the culture of human peripheral blood mononuclear cell (hPBMNC) fractions and are characterised by high proliferative and pro-vasculogenic potential, which makes them of great interest for cell ...
Tiago M Fortunato +3 more
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