Results 21 to 30 of about 53,843 (262)

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Role of Tryptase/PAR-2 in Vascular Endothelial Barrier Function

Journal of Pharmacological Sciences, 2005
Proteinase-activated receptor-2 (PAR-2) plays important roles in a variety of pathophysiological functions, including inflammatory responses and nociception.
Yoshinori Itoh, Toshiaki Sendo, Ryozo Oishi   +2 more
doaj   +1 more source

PAR-2 receptor-induced effects on human eccrine sweat gland cells

The Journal of Medical Investigation, 2009
Serine proteases can induce cell signaling by stimulating G-protein-coupled receptors, called proteinase-activated receptors (PAR's) on a variety of epithelial cells. While PAR-2, one such receptor, activates cell signaling in a secretory cell line derived from human sweat glands, there was no information on their presence and effects on intact sweat ...
Bovell, Douglas L, Kofler, Barbara, Lang, Roland   +2 more
openaire   +3 more sources

Increased Protease-Activated Receptor-2 (PAR-2) Expression on CD14++CD16+ Peripheral Blood Monocytes of Patients with Severe Asthma.

PLoS ONE, 2015
BackgroundProtease-Activated Receptor-2 (PAR-2), a G protein coupled receptor activated by serine proteases, is widely expressed in humans and is involved in inflammation.
Nami Shrestha Palikhe, Drew Nahirney, Cheryl Laratta, Vivek Dipak Gandhi, Dilini Vethanayagam, Mohit Bhutani, Irvin Mayers, Lisa Cameron, Harissios Vliagoftis   +8 more
doaj   +1 more source

Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris

Frontiers in Pharmacology, 2021
Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults.
Aneese A. Jaffa, Miran A. Jaffa, Mayssam Moussa, Ibrahim A. Ahmed, Mia Karam, Kawthar Sharaf Aldeen, Rola Al Sayegh, Rola Al Sayegh, Ghewa A. El-Achkar, Leila Nasrallah, Yara Yehya, Aida Habib, Aida Habib, Fuad N. Ziyadeh, Fuad N. Ziyadeh, Ali H. Eid, Ali H. Eid, Firas H. Kobeissy, Ayad A. Jaffa   +18 more
doaj   +1 more source

Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2

BMC Musculoskeletal Disorders, 2011
Background Mast cells contribute to tissue repair in fibrous tissues by stimulating proliferation of fibroblasts through the release of tryptase which activates protease-activated receptor-2 (PAR-2).
Côté Claude H, Tremblay Marie-Hélène, Duchesne Elise   +2 more
doaj   +1 more source

Proteinase-activated receptor-2: two potential inflammatory mediators of the gastrointestinal tract in Atlantic salmon

Journal of Inflammation, 2008
Proteinase-activated receptor 2 (PAR-2), activated by trypsin and other serine proteinases, is a key initiator of inflammatory responses in the intestine of mammals.
Valen Elin, Lilleeng Einar, Thorsen Jim, Krogdahl Åshild   +3 more
doaj   +1 more source

Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway

BMC Musculoskeletal Disorders, 2022
Objective Cancer-induced bone pain (CIBP) is a kind of pain with complex pathophysiology. Proteinase-activated receptor 2 (PAR-2) is involved in CIBP. This study explored the effects of PAR-2 on CIBP rats.
Yiting Tang, Yupeng Chen, Mingzhu Yang, Qiuhui Zheng, Yaoyuan Li, Yanju Bao   +5 more
doaj   +1 more source

PAR‐2 RECEPTORS MODULATE NERVE‐EVOKED CONTRACTION OF RESISTANCE ARTERIES

The FASEB Journal, 2013
The sympathetic nervous system regulates arterial diameter and thus blood flow and blood pressure. Protease‐activated receptors (PARs) are a novel class of G‐protein coupled receptors activated by protealytic cleavage of the extracellular domain to reveal a tethered ligand.
Paul Kerr, Myron Zwozdesky, Michael Chen, Ran Wei, Frances Plane   +4 more
openaire   +1 more source

Protease-Activated Receptor-2 Deficiency Attenuates Atherosclerotic Lesion Progression and Instability in Apolipoprotein E-Deficient Mice

Frontiers in Pharmacology, 2017
Inflammatory mechanisms are involved in the process of atherosclerotic plaque formation and rupture. Accumulating evidence suggests that protease-activated receptor (PAR)-2 contributes to the pathophysiology of chronic inflammation on the vasculature. To
Pengfei Zuo, Zhi Zuo, Yueyue Zheng, Xin Wang, Qianxing Zhou, Long Chen, Genshan Ma   +6 more
doaj   +1 more source

Basic and Translational Research on Proteinase-Activated Receptors: Implication of Proteinase/Proteinase-Activated Receptor in Gastrointestinal Inflammation

Journal of Pharmacological Sciences, 2008
Recently, the role of serine proteinases in the pathogenesis of inflammation and autoimmune diseases via interaction with the proteinase-activated receptor (PAR) has attracted attention.
Norimasa Yoshida, Toshikazu Yoshikawa
doaj   +1 more source