Results 11 to 20 of about 53,843 (262)

Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2 [PDF]

Journal of Biological Chemistry, 1997
Tryptase is a serine protease secreted by mast cells that is able to activate other cells. In the present studies we have tested whether these responses could be mediated by thrombin receptors or PAR-2, two G-protein-coupled receptors that are activated by proteolysis.
Albana Cumashi, Robert Numerof, Marina Molino, Mark Dreyer, Norman Schechter, James A. Hoxie, James D. Clark, Elliot S. Barnathan, Marilyn J. Woolkalis, Lawrence F. Brass   +9 more
openaire   +3 more sources

Investigation of Possible Role of the PAR-2 Receptor in Intestinal Inflammation [PDF]

Journal of Young Pharmacists, 2010
The present study was undertaken to study the role of PAR-2 receptor activation in pathophysiology of intestinal inflammation. Inflammatory bowel disease was induced in Wistar albino rats by intrarectal administration of 2, 4, 6 trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on 1(st) day only). Trypsin (500 μg/kg, 1
Patel, MB, Patel, MA, Shah, GB
openaire   +2 more sources

Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin. [PDF]

J Biol Chem, 2015
Protease-activated receptors (PARs) are a family of seven-transmembrane, G-protein-coupled receptors that are activated by multiple serine proteases through specific N-terminal proteolytic cleavage and the unmasking of a tethered ligand. The majority of PAR-activating proteases described to date are soluble proteases that are active during injury ...
Driesbaugh KH, Buzza MS, Martin EW, Conway GD, Kao JP, Antalis TM.   +5 more
europepmc   +4 more sources

Mast Cell Tryptase Stimulates DLD-1 Carcinoma Through Prostaglandin- and MAP Kinase-Dependent Manners

Journal of Pharmacological Sciences, 2005
We found that striptease-positive mast cells were abundant in the invasive front of human colon adenocarcinoma by examining 30 cases. Because tryptase has been suggested to be the agonist proteinase for protease-activated receptor-2 (PAR-2), we ...
Masanori Yoshii, Atsushi Jikuhara, Shuji Mori, Hiromi Iwagaki, Hideo K. Takahashi, Masahiro Nishibori, Noriaki Tanaka   +6 more
doaj   +1 more source

A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease. [PDF]

PLoS ONE, 2012
Pro-inflammatory cytokines like macrophage migration inhibitory factor (MIF), IL-1β and TNF-α predominate in inflammatory bowel diseases (IBD) and TNBS colitis.
Lara Moussa, Valérie Bézirard, Christel Salvador-Cartier, Valérie Bacquié, Corinne Lencina, Mathilde Lévêque, Viorica Braniste, Sandrine Ménard, Vassilia Théodorou, Eric Houdeau   +9 more
doaj   +1 more source

Jab1, a Novel Protease-activated Receptor-2 (PAR-2)-interacting Protein, Is Involved in PAR-2-induced Activation of Activator Protein-1 [PDF]

Journal of Biological Chemistry, 2006
Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor for trypsin and tryptase, exerts important physiological and pathological functions in multiple systems. However, unlike PAR-1, the PAR-2-mediated intracellular signal transductions are hardly known.
Weibo, Luo, Yingfei, Wang, Theodor, Hanck, Rolf, Stricker, Georg, Reiser   +4 more
openaire   +2 more sources

Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma. [PDF]

PLoS ONE, 2013
Trypsin or Tumor associated trypsin (TAT) activation of Protease-activated receptor 2 (PAR-2) promotes tumor cell proliferation in gastrointestinal cancers.
Song Han, Constance W Lee, Jose G Trevino, Steven J Hughes, George A Sarosi   +4 more
doaj   +1 more source

Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α) [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: Gentamicin (Gen) causes renal toxicity by inhibiting protein synthesis in kidney cells, causing proximal tubule cell necrosis and renal failure. Herein, we examined the nephroprotective effect of date palm seed extract (DPSE) and one herbal
Suliman Sohaim, Salman Mohammed, Elham Amin, Hussein M Ali, Mohamed Abdelbakky   +4 more
doaj   +1 more source

Evidence for the activation of PAR‐2 by the sperm protease, acrosin: expression of the receptor on oocytes

FEBS Letters, 2000
Proteinase‐activated receptor‐2 (PAR‐2) is a member of a family of G‐protein‐coupled, seven‐transmembrane domain receptors that are activated by proteolytic cleavage. The receptor is expressed in a number of different tissues and potential physiological activators identified thus far include trypsin and mast cell tryptase.
Smith, Rosealee, Jenkins, Alison, Lourbakos, Afrodite, Thompson, Philip, Ramakrishnan, Vanitha, Tomlinson, Jim, Deshpande, Usha, Johnson, David A., Jones, Roy, Mackie, Eleanor J., Pike, Robert N.   +10 more
openaire   +3 more sources

Protease‐Activated Receptor‐2 (PAR‐2) Is Present in the Rat Hippocampus and Is Associated with Neurodegeneration [PDF]

Journal of Neurochemistry, 1997
Abstract: Protease‐activated receptor‐2 (PAR‐2) is a seven‐transmembrane G protein‐coupled receptor that possesses a structure and activation mechanism similar to those of the thrombin receptor. It is activated by low concentrations of trypsin (300 pM) and a synthetic hexapeptide [sequence of serine, leucine, isoleucine, glycine, arginine, leucine ...
V L, Smith-Swintosky, C T, Cheo-Isaacs, M R, D'Andrea, R J, Santulli, A L, Darrow, P, Andrade-Gordon   +5 more
openaire   +2 more sources