Results 1 to 10 of about 306,043 (116)

Manipulation of tissue factor-mediated basal PAR-2 signalling on macrophages determines sensitivity for IFNγ responsiveness and significantly modifies the phenotype of murine DTH [PDF]

Frontiers in Immunology, 2022
BackgroundTissue factor (TF) generates proteases that can signal through PAR-1 and PAR-2. We have previously demonstrated PAR-1 signalling primes innate myeloid cells to be exquisitely sensitive to interferon-gamma (IFNγ). In this work we explored how TF
Hannah Wilkinson, Hugh Leonard, Michael G. Robson, Richard Smith, ElLi Tam, John H. McVey, Daniel Kirckhofer, Daxin Chen, Anthony Dorling   +8 more
doaj   +2 more sources

Mast Cells Mediate Inflammatory Injury and Aggravate Neurological Impairment in Experimental Subarachnoid Hemorrhage Through Microglial PAR-2 Pathway [PDF]

Frontiers in Cellular Neuroscience, 2021
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with high mortality and disability. Aberrant neuroinflammation has been identified as a critical factor accounting for the poor prognosis of SAH patients.
Bing Qin, Yucong Peng, Chen Zhong, Yong Cai, Shengjun Zhou, Huaijun Chen, Jianfeng Zhuang, Hanhai Zeng, Chaoran Xu, Hangzhe Xu, Jianru Li, Guangyu Ying, Chi Gu, Gao Chen, Lin Wang   +14 more
doaj   +2 more sources

Phellodendron amurense Extract Protects Human Keratinocytes from PM2.5-Induced Inflammation via PAR-2 Signaling [PDF]

Biomolecules, 2020
Dietary supplement and personal care products aiming to provide protection from air pollution have been of great interest for decades. Epidemiology demonstrated that PM10 and PM2.5 particulate matter (PM) are an actual threat to public health worldwide ...
Jiyoung Choi, Mi Yeon Moon, Gi Yeon Han, Moon Sik Chang, Dongki Yang, Joonseok Cha   +5 more
doaj   +2 more sources

Proteolytic activity of Triatoma infestans saliva associated with PAR-2 activation and vasodilation [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Triatoma infestans (Hemiptera: Reduviidae) is a hematophagous insect and the main vector of Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). In the present study, the authors investigated whether a serine protease activity from the saliva
Karla A. Oliveira, Ricardo J. S. Torquato, Daniela C. G. Garcia Lustosa, Tales Ribeiro, Bruno W. L. Nascimento, Lilian C. G. de Oliveira, Maria A. Juliano, Thaysa Paschoalin, Virginia S. Lemos, Ricardo N. Araujo, Marcos H. Pereira, Aparecida S. Tanaka   +11 more
doaj   +2 more sources

Mechanism of Lipid Accumulation through PAR2 Signaling in Diabetic Male Mice [PDF]

Endocrinology and Metabolism, 2021
Background Protease-activated protein-2 (PAR2) has been reported to regulate hepatic insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid metabolism through PAR2 in obesity mice have not yet been examined.
Dae Hyun Kim, Ye Ra Kim, EunJin Bang, Sugyeong Ha, Sang Gyun Noh, Byeong Moo Kim, Seong Ho Jeong, Hee Jin Jung, Ji Young Lee, Hae Young Chung   +9 more
doaj   +1 more source

Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer

Journal for ImmunoTherapy of Cancer, 2021
Metastatic colorectal cancers (mCRC) harboring microsatellite instability (MSI) are sensitive to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain unclear.
Romain Cohen, Vincent Jonchère, Toky Ratovomanana, Quentin Letourneur, Mira Ayadi, Lucile Armenoult, Adrien Buisson, Matthieu Sarabi, Anna Pellat, Francois Paye, Alex Duval   +10 more
doaj   +1 more source

Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway

BMC Musculoskeletal Disorders, 2022
Objective Cancer-induced bone pain (CIBP) is a kind of pain with complex pathophysiology. Proteinase-activated receptor 2 (PAR-2) is involved in CIBP. This study explored the effects of PAR-2 on CIBP rats.
Yiting Tang, Yupeng Chen, Mingzhu Yang, Qiuhui Zheng, Yaoyuan Li, Yanju Bao   +5 more
doaj   +1 more source

Protease-activated receptor-2: Role in asthma pathogenesis and utility as a biomarker of disease severity

Frontiers in Medicine, 2022
PAR2, a receptor activated by serine proteases, has primarily pro-inflammatory roles in the airways and may play a role in asthma pathogenesis. PAR2 exerts its effects in the lungs through activation of a variety of airway cells, but also activation of ...
Vivek Dipak Gandhi, Vivek Dipak Gandhi, Vivek Dipak Gandhi, Nami Shrestha Palikhe, Nami Shrestha Palikhe, Harissios Vliagoftis, Harissios Vliagoftis   +6 more
doaj   +1 more source

GSK3β, a Master Kinase in the Regulation of Adult Stem Cell Behavior

Cells, 2021
In adult stem cells, Glycogen Synthase Kinase 3β (GSK3β) is at the crossroad of signaling pathways controlling survival, proliferation, adhesion and differentiation.
Claire Racaud-Sultan, Nathalie Vergnolle
doaj   +1 more source

Nociceptive Sensitization by Activation of Protease-Activated Receptor 2 in a Rat Model of Incisional Pain

Brain Sciences, 2021
Postoperative pain and consequent inflammatory responses after tissue incision adversely affects many surgical patients due to complicated mechanisms.
Kanta Kido, Norika Katagiri, Hiromasa Kawana, Shigekazu Sugino, Masanori Yamauchi, Eiji Masaki   +5 more
doaj   +1 more source