Results 11 to 20 of about 306,192 (264)

PAR-2 Inhibition Reverses Experimental Pulmonary Hypertension [PDF]

Circulation Research, 2012
Rationale: A hallmark of the vascular remodeling process underlying pulmonary hypertension (PH) is the aberrant proliferation and migration of pulmonary arterial smooth muscle cells (PASMC).
Kwapiszewska, G., Markart, P., Dahal, B.K., Kojonazarov, B., Marsh, L.M., Schermuly, R.T., Taube, C., Meinhardt, A., Ghofrani, H.A., Steinhoff, M., Seeger, W., Preissner, K.T., Olschewski, A., Weissmann, N., Wygrecka, M.   +14 more
openaire   +3 more sources

Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma. [PDF]

PLoS ONE, 2013
Trypsin or Tumor associated trypsin (TAT) activation of Protease-activated receptor 2 (PAR-2) promotes tumor cell proliferation in gastrointestinal cancers.
Song Han, Constance W Lee, Jose G Trevino, Steven J Hughes, George A Sarosi   +4 more
doaj   +1 more source

Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation

Molecules, 2013
Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and anti-aging agent.
Eunsun Jung, Jung-A Lee, Seoungwoo Shin, Kyung-Baeg Roh, Jang-Hyun Kim, Deokhoon Park   +5 more
doaj   +1 more source

Utilisation d'un microfiltre tangentiel en oenologie

OENO One, 1984
A pilot tangential filter made by the Societe I D E and 4 different membranes were tested in a cooperative winery in the Gironde during the 1983 crush.
Michel Serrano, S. B. Sachs, Pascal Ribéreau-Gayon   +2 more
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2-Mediated Proliferation of Colon Cancer Cell

Journal of Pharmacological Sciences, 2005
Proteinase-activated receptor-2 (PAR-2) has been demonstrated to be highly expressed in the gastrointestinal tract. In the present minireview, we summarize the effects of PAR-1 and PAR-2 stimulation using their activating peptides and agonist proteinases
Masahiro Nishibori, Shuji Mori, Hideo K. Takahashi   +2 more
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

Journal of Pharmacological Sciences, 2005
PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases. In order to evaluate the therapeutic potential for PAR-2, we have performed studies on PAR-2-mediated signal ...
Toru Kanke, Toshiaki Takizawa, Mototsugu Kabeya, Atsufumi Kawabata   +3 more
doaj   +1 more source

Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome

Gut and Liver, 2016
Background/AimsPrevious studies have revealed that mast cells (MCs) may activate the protease-activated receptors and release of neuropeptides involved in the pathogenesis of irritable bowel syndrome (IBS).
doaj   +1 more source

Síndrome de microdeleção 2q32 em paciente da Amazônia ocidental

Medicina, 2023
Introdução: As deleções intersticiais envolvendo a região 2q31q32 são reconhecidas como um transtorno clínico, envolvendo diversas manifestações como deficiência intelectual, retardo no crescimento, distúrbios comportamentais e dismorfologias faciais ...
Wilyan Dias Cosmo Oliveira, Christian Rogers Gomes da Silva, Christopher Harrison Salomão Andrade, Edilson Moreira Borges, Gabriele Batista de Sá, Joshua Werner Bicalho da Rocha   +5 more
doaj  

Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.

PLoS ONE, 2014
Asthmatic bronchial smooth muscle (BSM) is characterized by structural remodeling associated with mast cell infiltration displaying features of chronic degranulation.
Benoit Allard, Imane Bara, Guillaume Gilbert, Gabrielle Carvalho, Thomas Trian, Annaig Ozier, Jennifer Gillibert-Duplantier, Olga Ousova, Elise Maurat, Matthieu Thumerel, Jean-François Quignard, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger   +13 more
doaj   +1 more source

Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation

Journal of Neuroinflammation, 2012
Activated microglia exerts both beneficial and deleterious effects on neurons, but the signaling mechanism controlling these distinct responses remain unclear.
Chen Chen-wen, Chen Qian-bo, Ouyang Qing, Sun Ji-hu, Liu Fang-ting, Song Dian-wen, Yuan Hong-bin   +6 more
doaj   +1 more source