Results 21 to 30 of about 91,883 (290)

Toll-like receptor 4 and Syk kinase shape dendritic cell-induced immune activation to major house dust mite allergens

Frontiers in Medicine, 2023
BackgroundHouse dust mite (HDM) is a major cause of respiratory allergic diseases. Dendritic cells (DCs) play a central role in orchestrating adaptive allergic immune responses. However, it remains unclear how DCs become activated by HDM.
Stefanie Busold, Stefanie Busold, Jaap H. Akkerdaas, Jaap H. Akkerdaas, Esther M. Zijlstra-Willems, Esther M. Zijlstra-Willems, Kees van der Graaf, Sander W. Tas, Sander W. Tas, Sander W. Tas, Esther C. de Jong, Esther C. de Jong, Ronald van Ree, Ronald van Ree, Ronald van Ree, Teunis B. H. Geijtenbeek, Teunis B. H. Geijtenbeek   +16 more
doaj   +1 more source

Q94 is not a selective modulator of proteinase-activated receptor 1 (PAR1) in platelets

Platelets, 2022
Thrombin is a potent platelet activator, acting through proteinase-activated receptors −1 and −4 (PAR1 and PAR4). Of these, PAR-1 is activated more rapidly and by lower thrombin concentrations.
Luc R. A. Francis, Sarah L. Millington-Burgess, Taufiq Rahman, Matthew T. Harper   +3 more
doaj   +1 more source

Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis

Memorias do Instituto Oswaldo Cruz, 2005
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes ...
M Holzhausen, LC Spolidorio, N Vergnolle
doaj   +1 more source

Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]

, 2008
Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription.
Kersten, A.H., Sander Kersten
core   +1 more source

Basic and Translational Research on Proteinase-Activated Receptors: Regulation of Nicotine Reward by the Tissue Plasminogen Activator (tPA) – Plasmin System via Proteinase-Activated Receptor 1

Journal of Pharmacological Sciences, 2008
Nicotine, a primary component of tobacco, is one of the most abused drugs worldwide. Mesolimbic dopaminergic neurons mediate the rewarding effects of abused drugs, including nicotine.
Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamada   +2 more
doaj   +1 more source

Single-cell analysis reveals melanocytes may promote inflammation in chronic wounds through cathepsin G

Frontiers in Genetics, 2023
During acute wound (AW) healing, a series of proper communications will occur between different epidermal cells at precise temporal stages to restore the integrity of the skin.
Aobuliaximu Yakupu, Aobuliaximu Yakupu, Di Zhang, Di Zhang, Haonan Guan, Haonan Guan, Minfei Jiang, Minfei Jiang, Jiaoyun Dong, Jiaoyun Dong, Yiwen Niu, Yiwen Niu, Jiajun Tang, Jiajun Tang, Yingkai Liu, Yingkai Liu, Xian Ma, Xian Ma, Shuliang Lu, Shuliang Lu   +19 more
doaj   +1 more source

Basic and Translational Research on Proteinase-Activated Receptors: Antagonism of the Proteinase-Activated Receptor 1 for Thrombin, a Novel Approach to Antiplatelet Therapy for Atherothrombotic Disease

Journal of Pharmacological Sciences, 2008
Atherothrombotic disease is a leading public health problem. Although current antiplatelet agents, such as aspirin and adenosine diphosphate (ADP)-receptor antagonists, reduce the morbidity and mortality associated with atherothrombotic disease, the ...
Madhu Chintala, Kenji Shimizu, Masami Ogawa, Hiroya Yamaguchi, Masaki Doi, Peder Jensen   +5 more
doaj   +1 more source

Proteinase-Activated Receptors

, 2013
© 2013 Elsevier Inc. All rights reserved. Serine proteinases signal to cells by cleaving and activating a four-member family of seven-transmembrane G-protein-coupled receptors (GPCRs) termed, proteinase-activated receptors (PARs). PARs are unique among GPCRs in having a mechanism of activation that involves the proteolytic cleavage and unmasking of a ...
Ramachandran, R., Hansen, K. K., Hollenberg, M. D.   +2 more
openaire   +4 more sources

Protease-activated receptors and inflammatory hyperalgesia

Memorias do Instituto Oswaldo Cruz, 2005
Recent advances in basic science pointed to a role for proteinases, through the activation of proteinase-activated receptors (PARs) in nociceptive mechanisms.
Nathalie Vergnolle
doaj   +1 more source

Protease-Activated Receptors – Key Regulators of Inflammatory Bowel Diseases Progression

Journal of Inflammation Research, 2021
Damian Jacenik,1 Jakub Fichna,2 Ewa Małecka-Wojciesko,3 Anna Mokrowiecka3 1Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland; 2Department of Biochemistry, Faculty of Medicine, Medical
Jacenik D, Fichna J, Małecka-Wojciesko E, Mokrowiecka A   +3 more
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