Results 31 to 40 of about 91,883 (290)
Biomedicines, 2021 Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder disorder with limited therapeutic options currently available. The present review provides an extensive overview of therapeutic approaches used in in vitro, ex vivo,
Tadeja Kuret +3 more
doaj +1 more source
Proteinase-activated receptors in the endometrium and endometriosis
Frontiers in Bioscience, 2012 Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR1 and PAR2 are expressed in endometrial cells from the eutopic endometrium and endometriotic cells derived from endometriotic lesions.
Yutaka, Osuga +5 more
openaire +3 more sources
The Enteric Nervous System in Inflammation and Pain: The Role of Proteinase-Activated Receptors
Canadian Journal of Gastroenterology, 2003 The enteric nervous system (ENS) plays a pivotal role in inflammatory and nociceptive processes. Drugs that interact with the ENS have recently raised considerable interest because of their capacity to regulate numerous aspects of the gut physiology and ...
Nathalie Vergnolle
doaj +1 more source
DVL as a scaffold protein capturing classical GPCRs
Communicative & Integrative Biology, 2010 The classical G-protein-coupled receptors (GPCRs) are characterized by their ability to interact with heterotrimeric G proteins upon activation and by structural features such as seven transmembrane spanning domains.
Hagit Turm +4 more
doaj +1 more source
Trehalose improves cell proliferation and dehydration tolerance of human HaCaT cells [PDF]
Archives of Biological Sciences, 2015 Trehalose is a disaccharide molecule that serves as a natural osmotic regulator in halophilic microorganisms and plants but not in mammals. We observed that human HaCaT cells supplied with trehalose improved cell proliferation and extended ...
Lee Kyung Eun +2 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Journal of Pharmacological Sciences, 2005 Proteinase-activated receptor-2 (PAR-2) has been demonstrated to be highly expressed in the gastrointestinal tract. In the present minireview, we summarize the effects of PAR-1 and PAR-2 stimulation using their activating peptides and agonist proteinases
Masahiro Nishibori +2 more
doaj +1 more source
Drug target mining and analysis of the Chinese tree shrew for pharmacological testing. [PDF]
PLoS ONE, 2014 The discovery of new drugs requires the development of improved animal models for drug testing. The Chinese tree shrew is considered to be a realistic candidate model.
Feng Zhao +5 more
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CCL4 Functions as a Biomarker of Type 2 Airway Inflammation
Biomedicines, 2022 Eosinophilic airway inflammatory disease is associated with bronchial asthma, with eosinophilic chronic rhinosinusitis (ECRS) typical of refractory type 2 airway inflammation.
Yoshiki Kobayashi +9 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source