Results 51 to 60 of about 91,883 (290)

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Burkhart, Julia M., Schwarz, Amelie, Christian Ries, Utzschneider, Daniel, Karolina Plaza, Debela, M., Amelie Schwarz, Plaza, Karolina, Beaufort, Nathalie, Creutzburg, Sabine, Ries, C., Schmitt, M., Burkhart, J. M., Beaufort, N., Plaza, K., Ries, Christian, Schwarz, A., Sabine Creutzburg, Mekdes Debela, Creutzburg, S., Schmitt, Manfred, Utzschneider, D., Julia M. Burkhart, Magdolen, Viktor, Debela, Mekdes, Viktor Magdolen, Nathalie Beaufort, Magdolen, V.   +27 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Screening of anti-inflammatory activity of 4.5-dihydroisoxazol-5-carboxamide (PAR-2 inhibitors) based on formaldehyde oedema model among white lab rats

Research Results in Pharmacology, 2023
Introduction: Rheumatoid arthritis (RА) is an immune-inflammatory disease intrinsic to up to 1.0% of the world’s population. Standard drugs for RA therapy are basic medications, glucocorticoids and non-steroid anti-inflammatory drugs, which often only ...
Mikhail K. Korsakov, Vladimir N. Fedorov, Nikolay A. Smirnov, Anton A. Shetnev, Olga V. Leonova, Nikita N. Volkhin, Aleksandr I. Andreyev   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Upregulation of proteinase activated receptors (PARs)and cardiovascular function

, 2003
Proteinase activated receptors (PARs) have attracted particular attention for their possible role in cardiovascular physiology and disease. The aim of this article is to review what is known up to now about the upregulation of PARs that are targets for ...
CICALA, CARLA, CIRINO, GIUSEPPE
core   +1 more source

Basic and Translational Research on Proteinase-Activated Receptors: The Role of Thrombin Receptor in Cerebral Vasospasm in Subarachnoid Hemorrhage

Journal of Pharmacological Sciences, 2008
Cerebral vasospasm is one of the major complications of subarachnoid hemorrhage (SAH). The prevention and treatment of cerebral vasospasm thus plays a critical role in the management of SAH patients.
Yasutoshi Kai, Yoshihisa Maeda, Tomio Sasaki, Hideo Kanaide, Katsuya Hirano   +4 more
doaj   +1 more source

Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

Scientific Reports, 2023
Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence. Mechanistic insights into OA pathophysiology are evolving and there are currently no disease-modifying OA drugs.
Arundhasa Chandrabalan, Andrew Firth, Robert B. Litchfield, C. Thomas Appleton, Alan Getgood, Rithwik Ramachandran   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Mecanismos envolvidos nas respostas nociceptivas e inflamatórias induzidas pela tripsina na pata de camundongos [PDF]

, 2007
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaAlém de funcionarem como enzimas de degradação, certas proteases atuam como moléculas de sinalização que regulam algumas ...
Paszcuk, Ana Flávia
core  

The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines [PDF]

, 2011
Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (K(iapp)=4.3 nM) and prevents phorbol ...
Sampaio, Misako U. [UNIFESP], Oliva, Maria Luiza V. [UNIFESP], Maria Luiza V. Oliva, Mayer, Barbara, Neth, Peter, Andrade de Paula, Claudia Alessandra [UNIFESP], Sampaio, Misako U., Nakahata, Adriana Miti [UNIFESP], Christian Ries, Adriana Miti Nakahata, Andrade de Paula, Claudia Alessandra, Karow, Marisa, Barbara Mayer, Cláudia Alessandra Andrade de Paula, Marisa Karow, Marianne Jochum, Oliva, Maria Luiza V., Jochum, Marianne, Misako U. Sampaio, Ries, Christian, Nakahata, Adriana Miti, Peter Neth   +21 more
core   +1 more source