Results 1 to 10 of about 49,213 (108)

Proteinase Activated Receptors Mediate the Trypsin-Induced Ca2 + Signaling in Human Uterine Epithelial Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Embryo implantation is a complex and tightly regulated process. In humans, uterine luminal epithelium functions as a biosensor gauging the embryo quality and transmitting this information to the underlying endometrial stromal cells.
Anatoliy Shmygol, Jan J. Brosens, Jan J. Brosens   +2 more
doaj   +2 more sources

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease [PDF]

Journal of Immunology Research, 2017
Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial ...
E. S. Rovai, M. Holzhausen
doaj   +2 more sources

Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors. [PDF]

PLoS ONE, 2011
Implantation S1 family serine proteinases (ISPs) are tryptases involved in embryo hatching and uterine implantation in the mouse. The two different ISP proteins (ISP1 and ISP2) have been detected in both pre- and post-implantation embryo tissue. To date,
Navneet Sharma, Rajeev Kumar, Bernard Renaux, Mahmoud Saifeddine, Sandra Nishikawa, Koichiro Mihara, Rithwik Ramachandran, Morley D Hollenberg, Derrick E Rancourt   +8 more
doaj   +2 more sources

Structural basis for the activation of proteinase-activated receptors PAR1 and PAR2 [PDF]

Nature Communications
Members of the proteinase-activated receptor (PAR) subfamily of G protein-coupled receptors (GPCRs) play critical roles in processes like hemostasis, thrombosis, development, wound healing, inflammation, and cancer progression.
Zongyang Lyu, Xiaoxuan Lyu, Andrey G. Malyutin, Guliang Xia, Daniel Carney, Vinicius M. Alves, Matthew Falk, Nidhi Arora, Hua Zou, Aaron P. McGrath, Yanyong Kang   +10 more
doaj   +2 more sources

Induction of Tumor Necrosis Factor (TNF) Release from Subtypes of T Cells by Agonists of Proteinase Activated Receptors [PDF]

Mediators of Inflammation, 2013
Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells.
Haiwei Yang, Tao Li, Jifu Wei, Huiyun Zhang, Shaoheng He   +4 more
doaj   +2 more sources

Basic and Translational Research on Proteinase-Activated Receptors: Proteinase-Activated Receptors in Female Reproductive Tissues and Endometriosis

Journal of Pharmacological Sciences, 2008
During the menstrual cycle, dynamic morphological changes are observed in the ovarian follicle and the endometrium. These changes are associated with the onset of the inflammatory response in which many proteinases play various roles.
Yutaka Osuga, Yasushi Hirota, Yuji Taketani   +2 more
doaj   +3 more sources

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PARs in the Respiratory System: Cellular Signaling and Physiological/Pathological Roles

Journal of Pharmacological Sciences, 2005
Proteinase-activated receptors (PARs), a family of G protein-coupled receptors, are widely distributed in the mammalian body, playing a variety of physiological/pathophysiological roles. In the respiratory systems, PARs, particularly PAR-2 and PAR-1, are
Kawabata Atsufumi, Naoyuki Kawao
doaj   +3 more sources

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Regulation of the Expression of PARs

Journal of Pharmacological Sciences, 2005
The level of receptors expressed on the cell surface determines the cellular responsiveness to agonists. Proteinase-activated receptors (PARs) have been reported to be either upregulated or down-regulated in response to various types of stimulation and ...
Katsuya Hirano, Tatsuya Yufu, Mayumi Hirano, Junji Nishimura, Hideo Kanaide   +4 more
doaj   +3 more sources

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

Journal of Pharmacological Sciences, 2005
PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases. In order to evaluate the therapeutic potential for PAR-2, we have performed studies on PAR-2-mediated signal ...
Toru Kanke, Toshiaki Takizawa, Mototsugu Kabeya, Atsufumi Kawabata   +3 more
doaj   +3 more sources

Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice

Journal of Pharmacological Sciences, 2008
Proteinase-activated receptor-2 (PAR2) participates in itch, but the role of the other subtypes of this receptor remain unknown. To investigate this issue, scratching, an itch-related behavior, was observed following intradermal injections of the ...
Kenichiro Tsujii, Tsugunobu Andoh, Jung-Bum Lee, Yasushi Kuraishi   +3 more
doaj   +3 more sources