Results 11 to 20 of about 49,362 (244)

Basic and Translational Research on Proteinase-Activated Receptors: Implication of Proteinase/Proteinase-Activated Receptor in Gastrointestinal Inflammation

Journal of Pharmacological Sciences, 2008
Recently, the role of serine proteinases in the pathogenesis of inflammation and autoimmune diseases via interaction with the proteinase-activated receptor (PAR) has attracted attention.
Norimasa Yoshida, Toshikazu Yoshikawa
doaj   +4 more sources

Cofactoring and dimerization of proteinase-activated receptors. [PDF]

Pharmacol Rev, 2013
Proteinase-activated receptors (PARs) are G protein-coupled receptors that transmit cellular responses to extracellular proteases and have important functions in vascular physiology, development, inflammation, and cancer progression. The established paradigm for PAR activation involves proteolytic cleavage of the extracellular N terminus, which reveals
Lin H, Liu AP, Smith TH, Trejo J.
europepmc   +6 more sources

Gastrointestinal roles for proteinase‐activated receptors in health and disease [PDF]

British Journal of Pharmacology, 2008
Atsufumi Kawabata
exaly   +2 more sources

Proteinase-activated receptors 1 and 2 activate protein kinase D1 in human melanoma cells [PDF]

Cell Communication and Signaling, 2009
Dummer R, Haußer A, Hoek KS, Bocheva GS, Rattenholl A, Kempkes C, Steinhoff M   +6 more
doaj   +2 more sources

Epithelial effects of proteinase-activated receptors in the gastrointestinal tract

Memorias do Instituto Oswaldo Cruz, 2005
The intestinal epithelium plays a crucial role in providing a barrier between the external environment and the internal milieu of the body. A compromised mucosal barrier is characteristic of mucosal inflammation and is a key determinant of the ...
Wallace K MacNaughton
doaj   +1 more source

NLRP3 Inflammasome and Its Critical Role in Gynecological Disorders and Obstetrical Complications

Frontiers in Immunology, 2021
Inflammasomes, intracellular, multimeric protein complexes, are assembled when damage signals stimulate nucleotide-binding oligomerization domain receptors (NLRs).
Xuhui Fang, Yanshi Wang, Yu Zhang, Yelin Li, Joanne Kwak-kim, Joanne Kwak-kim, Li Wu   +6 more
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Proteinases as Hormone-Like Signal Messengers: PARs and More

Journal of Pharmacological Sciences, 2005
Proteinases like thrombin and trypsin, long known for their ability to activate the coagulation cascade or to act as digestive enzymes for many protein targets, are now recognized as hormone-like regulators of cell function.
Morley D. Hollenberg
doaj   +1 more source

Proteinase-activated Receptors, Targets for Kallikrein Signaling [PDF]

Journal of Biological Chemistry, 2006
Serine proteinases like thrombin can signal to cells by the cleavage/activation of proteinase-activated receptors (PARs). Although thrombin is a recognized physiological activator of PAR(1) and PAR(4), the endogenous enzymes responsible for activating PAR(2) in settings other than the gastrointestinal system, where trypsin can activate PAR(2), are ...
Oikonomopoulou, K., Hansen, K. K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S. I., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G. S., Bunnett, N. W., Diamandis, E. P., Hollenberg, M. D.   +11 more
openaire   +3 more sources

Toll-like receptor 4 and Syk kinase shape dendritic cell-induced immune activation to major house dust mite allergens

Frontiers in Medicine, 2023
BackgroundHouse dust mite (HDM) is a major cause of respiratory allergic diseases. Dendritic cells (DCs) play a central role in orchestrating adaptive allergic immune responses. However, it remains unclear how DCs become activated by HDM.
Stefanie Busold, Stefanie Busold, Jaap H. Akkerdaas, Jaap H. Akkerdaas, Esther M. Zijlstra-Willems, Esther M. Zijlstra-Willems, Kees van der Graaf, Sander W. Tas, Sander W. Tas, Sander W. Tas, Esther C. de Jong, Esther C. de Jong, Ronald van Ree, Ronald van Ree, Ronald van Ree, Teunis B. H. Geijtenbeek, Teunis B. H. Geijtenbeek   +16 more
doaj   +1 more source

Q94 is not a selective modulator of proteinase-activated receptor 1 (PAR1) in platelets

Platelets, 2022
Thrombin is a potent platelet activator, acting through proteinase-activated receptors −1 and −4 (PAR1 and PAR4). Of these, PAR-1 is activated more rapidly and by lower thrombin concentrations.
Luc R. A. Francis, Sarah L. Millington-Burgess, Taufiq Rahman, Matthew T. Harper   +3 more
doaj   +1 more source