Results 21 to 30 of about 49,362 (244)

Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis

Memorias do Instituto Oswaldo Cruz, 2005
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes ...
M Holzhausen, LC Spolidorio, N Vergnolle
doaj   +1 more source

Basic and Translational Research on Proteinase-Activated Receptors: Regulation of Nicotine Reward by the Tissue Plasminogen Activator (tPA) – Plasmin System via Proteinase-Activated Receptor 1

Journal of Pharmacological Sciences, 2008
Nicotine, a primary component of tobacco, is one of the most abused drugs worldwide. Mesolimbic dopaminergic neurons mediate the rewarding effects of abused drugs, including nicotine.
Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamada   +2 more
doaj   +1 more source

Single-cell analysis reveals melanocytes may promote inflammation in chronic wounds through cathepsin G

Frontiers in Genetics, 2023
During acute wound (AW) healing, a series of proper communications will occur between different epidermal cells at precise temporal stages to restore the integrity of the skin.
Aobuliaximu Yakupu, Aobuliaximu Yakupu, Di Zhang, Di Zhang, Haonan Guan, Haonan Guan, Minfei Jiang, Minfei Jiang, Jiaoyun Dong, Jiaoyun Dong, Yiwen Niu, Yiwen Niu, Jiajun Tang, Jiajun Tang, Yingkai Liu, Yingkai Liu, Xian Ma, Xian Ma, Shuliang Lu, Shuliang Lu   +19 more
doaj   +1 more source

Basic and Translational Research on Proteinase-Activated Receptors: Antagonism of the Proteinase-Activated Receptor 1 for Thrombin, a Novel Approach to Antiplatelet Therapy for Atherothrombotic Disease

Journal of Pharmacological Sciences, 2008
Atherothrombotic disease is a leading public health problem. Although current antiplatelet agents, such as aspirin and adenosine diphosphate (ADP)-receptor antagonists, reduce the morbidity and mortality associated with atherothrombotic disease, the ...
Madhu Chintala, Kenji Shimizu, Masami Ogawa, Hiroya Yamaguchi, Masaki Doi, Peder Jensen   +5 more
doaj   +1 more source

Protease-activated receptors and inflammatory hyperalgesia

Memorias do Instituto Oswaldo Cruz, 2005
Recent advances in basic science pointed to a role for proteinases, through the activation of proteinase-activated receptors (PARs) in nociceptive mechanisms.
Nathalie Vergnolle
doaj   +1 more source

Protease-Activated Receptors – Key Regulators of Inflammatory Bowel Diseases Progression

Journal of Inflammation Research, 2021
Damian Jacenik,1 Jakub Fichna,2 Ewa Małecka-Wojciesko,3 Anna Mokrowiecka3 1Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland; 2Department of Biochemistry, Faculty of Medicine, Medical
Jacenik D, Fichna J, Małecka-Wojciesko E, Mokrowiecka A   +3 more
doaj  

Trehalose improves cell proliferation and dehydration tolerance of human HaCaT cells [PDF]

Archives of Biological Sciences, 2015
Trehalose is a disaccharide molecule that serves as a natural osmotic regulator in halophilic microorganisms and plants but not in mammals. We observed that human HaCaT cells supplied with trehalose improved cell proliferation and extended ...
Lee Kyung Eun, Moon Doo Hwan, Kang Sang Gu   +2 more
doaj   +1 more source

A Systematic Review of Therapeutic Approaches Used in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome

Biomedicines, 2021
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder disorder with limited therapeutic options currently available. The present review provides an extensive overview of therapeutic approaches used in in vitro, ex vivo,
Tadeja Kuret, Dominika Peskar, Andreja Erman, Peter Veranič   +3 more
doaj   +1 more source

Proteinase-activated receptors in the endometrium and endometriosis

Frontiers in Bioscience, 2012
Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR1 and PAR2 are expressed in endometrial cells from the eutopic endometrium and endometriotic cells derived from endometriotic lesions.
Yutaka, Osuga, Yasushi, Hirota, Osamu, Yoshino, Tetsuya, Hirata, Kaori, Koga, Yuji, Taketani   +5 more
openaire   +3 more sources

The Enteric Nervous System in Inflammation and Pain: The Role of Proteinase-Activated Receptors

Canadian Journal of Gastroenterology, 2003
The enteric nervous system (ENS) plays a pivotal role in inflammatory and nociceptive processes. Drugs that interact with the ENS have recently raised considerable interest because of their capacity to regulate numerous aspects of the gut physiology and ...
Nathalie Vergnolle
doaj   +1 more source