Results 11 to 20 of about 91,883 (290)

Cofactoring and Dimerization of Proteinase-Activated Receptors [PDF]

Pharmacological Reviews, 2013
Proteinase-activated receptors (PARs) are G protein-coupled receptors that transmit cellular responses to extracellular proteases and have important functions in vascular physiology, development, inflammation, and cancer progression. The established paradigm for PAR activation involves proteolytic cleavage of the extracellular N terminus, which reveals
Lin, Huilan, Liu, Allen P, Smith, Thomas H, Trejo, JoAnn, Christopoulos, Arthur   +4 more
openaire   +5 more sources

Proteinase-Activated Receptors of Digestive Systems

Медицинский вестник Юга России, 2012
The enzymes exosecreted by digestive glands, especially proteinases have not only digestive but signal role. The role is realized by means of regulatory peptide formation, stimulation and inhibition of their release, stimulation of special proteinase ...
G. F. Korotko
doaj   +2 more sources

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease [PDF]

Journal of Immunology Research, 2017
Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial ...
E. S. Rovai, M. Holzhausen
doaj   +2 more sources

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic Target

Journal of Pharmacological Sciences, 2005
PAR-2 is the second member of the family of proteinase-activated receptors activated by trypsin, tryptase, and several other serine proteinases. In order to evaluate the therapeutic potential for PAR-2, we have performed studies on PAR-2-mediated signal ...
Toru Kanke, Toshiaki Takizawa, Mototsugu Kabeya, Atsufumi Kawabata   +3 more
doaj   +2 more sources

Proteinase-activated receptors in GtoPdb v.2021.3

, 2021
Proteinase-activated receptors (PARs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Proteinase-activated Receptors [39]) are unique members of the GPCR superfamily activated by proteolytic cleavage of their amino terminal exodomains.
Hamilton, Justin, Hollenberg, Morley D., Ramachandran, Rithwik, Bunnett, Nigel, DeFea, Kathryn, Trejo, JoAnn   +5 more
core   +1 more source

Proteinase-activated receptors in GtoPdb v.2023.1

, 2023
Proteinase-activated receptors (PARs, nomenclature as agreed by the NC-IUPHAR Subcommittee on Proteinase-activated Receptors [39]) are unique members of the GPCR superfamily activated by proteolytic cleavage of their amino terminal exodomains.
Hamilton, Justin, Hollenberg, Morley D., Justin Hamilton, Ramachandran, Rithwik, Rithwik Ramachandran, Kathryn DeFea, Bunnett, Nigel, DeFea, Kathryn, JoAnn Trejo, Trejo, JoAnn, Nigel Bunnett, Morley D. Hollenberg   +11 more
core   +1 more source

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis [PDF]

, 2010
<b>Objective:</b> Osteoarthritis is a global clinical challenge for which no effective disease-modifying agents currently exist. This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential ...
McInnes, I.B., Lockhart, J.C., Plevin, R., Elizabeth B Kelso, Robin Plevin, Iain B McInnes, Ferrell, W.R., Kelso, E.B., Plevin, R.J., William R Ferrell, John C Lockhart   +10 more
core   +1 more source

NLRP3 Inflammasome and Its Critical Role in Gynecological Disorders and Obstetrical Complications

Frontiers in Immunology, 2021
Inflammasomes, intracellular, multimeric protein complexes, are assembled when damage signals stimulate nucleotide-binding oligomerization domain receptors (NLRs).
Xuhui Fang, Yanshi Wang, Yu Zhang, Yelin Li, Joanne Kwak-kim, Joanne Kwak-kim, Li Wu   +6 more
doaj   +1 more source

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Proteinases as Hormone-Like Signal Messengers: PARs and More

Journal of Pharmacological Sciences, 2005
Proteinases like thrombin and trypsin, long known for their ability to activate the coagulation cascade or to act as digestive enzymes for many protein targets, are now recognized as hormone-like regulators of cell function.
Morley D. Hollenberg
doaj   +1 more source

Proteinase-activated Receptors, Targets for Kallikrein Signaling [PDF]

Journal of Biological Chemistry, 2006
Serine proteinases like thrombin can signal to cells by the cleavage/activation of proteinase-activated receptors (PARs). Although thrombin is a recognized physiological activator of PAR(1) and PAR(4), the endogenous enzymes responsible for activating PAR(2) in settings other than the gastrointestinal system, where trypsin can activate PAR(2), are ...
Oikonomopoulou, K., Hansen, K. K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S. I., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G. S., Bunnett, N. W., Diamandis, E. P., Hollenberg, M. D.   +11 more
openaire   +3 more sources