Results 21 to 30 of about 42,405 (307)

Coagulation, Microenvironment and Liver Fibrosis

Cells, 2018
Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and thrombin generation are crucial in the physiological response to tissue injury; however, the inappropriate and uncontrolled activation of coagulation cascade may lead ...
Niccolò Bitto, Eleonora Liguori, Vincenzo La Mura   +2 more
doaj   +1 more source

Effects of intermittent hypoxia with thrombin in an in vitro model of human brain endothelial cells and their impact on PAR-1/PAR-3 cleavage

Scientific Reports, 2022
Patients with obstructive sleep apnea/hypopnea (OSA) are at high risk of cerebrovascular diseases leading to cognitive impairment. The oxidative stress generated by intermittent hypoxia (IH) could lead to an increase in blood–brain barrier (BBB ...
Cindy Zolotoff, Clémentine Puech, Frédéric Roche, Nathalie Perek   +3 more
doaj   +1 more source

Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone.

PLoS ONE, 2020
Intrauterine bleeding during pregnancy is a major risk factor for preterm birth. Thrombin, the most abundant coagulation factor in blood, is associated with uterine myometrial contraction.
Fumitomo Nishimura, Haruta Mogami, Kaori Moriuchi, Yoshitsugu Chigusa, Masaki Mandai, Eiji Kondoh   +5 more
doaj   +1 more source

Thrombin induces morphological and inflammatory astrocytic responses via activation of PAR1 receptor

Cell Death Discovery, 2022
Spinal cord injury (SCI) will result in the significant elevation of thrombin production at lesion site via either breakage of blood-spinal cord barrier or upregulated expression within nerve cells.
Xiaojun Chen, Han Zhang, Huifei Hao, Xingyuan Zhang, Honghua Song, Bingqiang He, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu, Yongjun Wang   +10 more
doaj   +1 more source

A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin. [PDF]

PLoS ONE, 2011
BACKGROUND: We have shown that 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose (α-PGG), an orally effective hypoglycemic small molecule, binds to insulin receptors and activates insulin-mediated glucose transport.
Rehana Perveen, Kevin Funk, Jean Thuma, Shelli Wulf Ridge, Yanyan Cao, Jan Willem N Akkerman, Xiaozhuo Chen, Huzoor Akbar   +7 more
doaj   +1 more source

Increased mucosal thrombin is associated with Crohn's disease and causes inflammatory damage through Protease-Activated Receptors activation [PDF]

, 2021
International audienceBackground and Aims: Thrombin levels in the colon of Crohn’s disease patients have recently been found to be elevated 100-fold compared to healthy controls.
Denadai-Souza, Alexandre, Rousset, Perrine, Motta, Jean-Paul, Gilletta, Cyrielle, Chapman, Kevin, Alric, Laurent, Edir, Anissa, Wallace, John, Wallace, John L., Le Grand, Bruno, Deraison, Céline, Buret, Andre G., Seguy, Carine, Buscail, Louis, Bonnet, Delphine, Oswald, Eric, Vergnolle, Nathalie, Barocelli, Elisabetta, Palese, Simone, Buret, Andre, Hollenberg, Morley, Le Grand, Sylvie, Hollenberg, Morley D., Guiraud, Laura, Bournet, Barbara, Giorgio, Carmine, Sagnat, David   +26 more
core   +2 more sources

Platelet thrombin receptor antagonism and atherothrombosis [PDF]

European Heart Journal, 2009
Clinical manifestations of atherothrombotic disease, such as acute coronary syndromes, cerebrovascular events, and peripheral arterial disease, are major causes of mortality and morbidity worldwide. Platelet activation and aggregation are ultimately responsible for the progression and clinical presentations of atherothrombotic disease.
ANGIOLILLO DJ, CAPODANNO, DAVIDE FRANCESCO MARIA, GOTHO S.   +2 more
openaire   +3 more sources

Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

Reproductive Biology and Endocrinology, 2005
Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs), and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects
Elliott John T, Friel Anne M, Ravikumar Nandini, O'Sullivan Crochan J, O'Loughlin Aonghus J, Morrison John J   +5 more
doaj   +1 more source

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)

, 2012
Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh
Robben, Joris, Cooke, Alexandra, Gould, Gwyn W., McIntosh, Kathryn A., Gould, Gwyn, Milligan, Graeme, Cunningham, Margaret Rose, Pediani, John D., Cooke, Alexandra E., McIntosh, Kathryn, Nilsson, Mary, Mundell, Stuart, Plevin, Robin, Cunningham, Margaret R., McIntosh, Kathryn A, Pediani, John D, Gould, Gwyn W, Pediani, John, Nilsson, Mary Francis, Cunningham, Margaret R, Cooke, Alexandra E   +20 more
core   +1 more source

Thrombin induces macrophage migration inhibitory factor release and upregulation in urothelium: a possible contribution to bladder inflammation. [PDF]

PLoS ONE, 2010
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine expressed by urothelial cells that mediates bladder inflammation. We investigated the effect of stimulation with thrombin, a Protease Activated Receptor-1 (PAR1) agonist, on MIF ...
Pedro L Vera, Terra E Wolfe, Alexander E Braley, Katherine L Meyer-Siegler   +3 more
doaj   +1 more source