Results 1 to 10 of about 3,246,752 (251)

Microplastic Effects on Thrombin–Fibrinogen Clotting Dynamics Measured via Turbidity and Thromboelastography

Biomolecules, 2022
Micro/nanoplastics, whether manufactured or resulting from environmental degradation, can enter the body through ingestion, inhalation, or dermal pathways.
Daniela Q. Tran, Nathan Stelflug, Abigail Hall, Tanmaye Nallan Chakravarthula, Nathan J. Alves   +4 more
doaj   +3 more sources

Fluorescence resonance energy transfer (FRET) spatiotemporal mapping of atypical P38 reveals an endosomal and cytosolic spatial bias

Scientific Reports, 2023
Mitogen-activated protein kinase (MAPK) p38 is a central regulator of intracellular signaling, driving physiological and pathological pathways. With over 150 downstream targets, it is predicted that spatial positioning and the availability of cofactors ...
Jeremy C. Burton, Jennifer Okalova, Neil J. Grimsey   +2 more
doaj   +1 more source

SCREENING OF CLOTTING SYSTEM DISORDERS BY LABORATORY TESTS

Российский кардиологический журнал, 2015
The review takes into consideration the diagnostic significance of the main screening coagulologic tests under the light of modern views on the role of vessel wall, plasma proteins and blood cells in the dynamics of thrombin formation and its activities ...
A. B. Dobrovolsky, E. V. Titaeva
doaj   +1 more source

Identification, screening, and comprehensive evaluation of novel thrombin inhibitory peptides from the hirudo produced using pepsin

Frontiers in Pharmacology
PurposeThe inhibition of thrombin has proven to be an efficacious therapeutic approach for managing cardiovascular disease (CVD), with widespread implementation in clinical settings.
Xiaoyu Chai, Fulu Pan, Qianqian Wang, Xinyu Wang, Xueyan Li, Dongying Qi, Zirong Yi, Huan Liu, Jing Zhang, Yiming Zhang, Yanli Pan, Yang Liu, Guopeng Wang   +12 more
doaj   +1 more source

Determination of fibrin clot growth and spatial thrombin propagation in the presence of different types of phospholipid surfaces

Platelets, 2021
In this work, we present a new method—Thrombodynamics-4D—for the assessment of both plasma and platelet contributions to clotting. Thrombodynamics-4D potentially allows for the determination of plasma or platelet disorders and the effects of various ...
Ekaterina M. Koltsova, Anna D. Kuprash, Natalya M. Dashkevich, David M. Vardanyan, Artem V. Chernyakov, Maria A. Kumskova, Sukesh C. Nair, Alok Srivastava, Fazoil I. Ataullakhanov, Mikhail A. Panteleev, Anna N. Balandina   +10 more
doaj   +1 more source

Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury

Neurobiology of Disease, 2016
The deregulation of serine protease activity is a common feature of neurological injury, but little is known regarding their mechanisms of action or whether they can be targeted to facilitate repair.
Maja Radulovic, Hyesook Yoon, Jianmin Wu, Karim Mustafa, Isobel A. Scarisbrick   +4 more
doaj   +1 more source

Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review

Thrombosis Journal, 2018
Background The pathophysiological mechanisms of acute coagulopathy of trauma-shock (ACOTS) are reported to include activated protein C-mediated suppression of thrombin generation via the proteolytic inactivation of activated Factor V (FVa) and FVIIIa; an
Satoshi Gando, Toshihiko Mayumi, Tomohiko Ukai   +2 more
doaj   +1 more source

Live imaging of the Drosophila ovarian germline stem cell niche

STAR Protocols, 2021
Summary: The maintenance of stem cell populations and the differentiation of their progeny is coordinated by specific communication with associated niche cells.
Scott G. Wilcockson, Hilary L. Ashe
doaj   +1 more source

Grafting thrombin onto FITC-labeled gelatin nanoparticles as a candidate embolic agent: In vitro preparation and procoagulant characterization

Next Materials
Objective: Thromboembolic disorders remain a major global health concern, especially in the context of vascular injury and inflammation. In this study, we developed FITC-dextran-labeled gelatin nanoparticles (Gel-FITC NPs) conjugated with thrombin to ...
Soheil Mirzaei, Ehteram Tajik, Zahra Vaezi, Hossein Naderi-Manesh, Taki Tiraihi   +4 more
doaj   +1 more source

Trypanosoma brucei modifies the tsetse salivary composition, altering the fly feeding behavior that favors parasite transmission. [PDF]

PLoS Pathogens, 2010
Tsetse flies are the notorious transmitters of African trypanosomiasis, a disease caused by the Trypanosoma parasite that affects humans and livestock on the African continent.
Jan Van Den Abbeele, Guy Caljon, Karin De Ridder, Patrick De Baetselier, Marc Coosemans   +4 more
doaj   +1 more source