Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay [PDF]
Frontiers in Cardiovascular Medicine, 2022 BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo +8 more
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Reference values for thrombin dynamics in platelet rich plasma
Platelets, 2021 Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan +3 more
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Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin. [PDF]
PLoS ONE, 2015 Biomolecular recognition is crucial in cellular signal transduction. Signaling is mediated through molecular interactions at protein-protein interfaces. Still, specificity and promiscuity of protein-protein interfaces cannot be explained using simplistic
Julian E Fuchs +6 more
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Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex [PDF]
Scientific Reports, 2021 Serine proteases catalyze a multi-step covalent catalytic mechanism of peptide bond cleavage. It has long been assumed that serine proteases including thrombin carry-out catalysis without significant conformational rearrangement of their stable two-β ...
Riley B. Peacock +3 more
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Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies. [PDF]
PLoS ONE, 2011 Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution.
Vivian de Almeira Silva +6 more
doaj +5 more sources
Thrombin activity confinement and dense granule release drive the dynamics of arterial thrombus. [PDF]
PLoS Computational BiologyThe mechanisms driving spatial heterogeneity of arterial thrombus and its three-stage dynamics are poorly understood. To investigate the potential principles regulating the size of the thrombus core and shell we developed a 3D continuum computational ...
Efim S Bershadsky, Dmitry Y Nechipurenko
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Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: The thrombin dynamics method has been used as an add-on analysis method for the thrombin generation test over the past years to study the balance between pro- and anticoagulant pathways.
Amalia De Curtis +51 more
doaj +2 more sources
Personalized modulation of coagulation factors using a thrombin dynamics model to treat trauma-induced coagulopathy [PDF]
npj Systems Biology and Applications, 2021 Current trauma-induced coagulopathy resuscitation protocols use slow laboratory measurements, rules-of-thumb, and clinician gestalt to administer large volumes of uncharacterized, non-tailored blood products.
Damon E. Ghetmiri +2 more
doaj +2 more sources
Dynamics of thrombin-induced exposition of actin on the platelet surface [PDF]
The Ukrainian Biochemical Journal, 2014 Platelets play the key role in thrombosis and are also involved in angiogenesis as well as immune and reparative responses. In the function cascade, platelets undergo a complex cell processing, and subcellular fragments, not detectable in the resting ...
A. A. Tykhomyrov
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Study of the Differential Activity of Thrombin Inhibitors Using Docking, QSAR, Molecular Dynamics, and MM-GBSA. [PDF]
PLoS ONE, 2015 Non-peptidic thrombin inhibitors (TIs; 177 compounds) with diverse groups at motifs P1 (such as oxyguanidine, amidinohydrazone, amidine, amidinopiperidine), P2 (such as cyanofluorophenylacetamide, 2-(2-chloro-6-fluorophenyl)acetamide), and P3 (such as ...
Karel Mena-Ulecia +2 more
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