Results 11 to 20 of about 18,386 (273)
Deciphering the coagulation profile through the dynamics of thrombin activity [PDF]
Scientific Reports, 2020 AbstractThrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we have named thrombin dynamics. Via this method we are able to exactly measure
de Laat-Kremers, Romy M. W. +4 more
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Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin [PDF]
Biochemistry, 2018 Thrombin normally cleaves fibrinogen to promote coagulation; however, binding of thrombomodulin to thrombin switches the specificity of thrombin toward protein C, triggering the anticoagulation pathway. The W215A thrombin mutant was reported to have decreased activity toward fibrinogen without significant loss of activity toward protein C.
Riley B. Peacock +3 more
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Scientific Reports, 2017 Platelets are small anucleate blood cells involved in haemostasis. Platelet activation, caused by agonists such as thrombin or by contact with the extracellular matrix, leads to platelet adhesion, aggregation, and coagulation. Activated platelets undergo
Jan Seifert +4 more
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Molecular dynamics simulations of aptamer-binding reveal generalized allostery in thrombin [PDF]
Journal of Biomolecular Structure and Dynamics, 2016 Thrombin is an attractive target for antithrombotic therapy due to its central role in thrombosis and hemostasis as well as its role in inducing tumor growth, metastasis, and tumor invasion. The thrombin-binding DNA aptamer (TBA), is under investigation for anticoagulant drugs.
Jiajie, Xiao, Freddie R, Salsbury
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DNA‐Guided Robust Single‐Protein Electronic Readout [PDF]
Advanced ScienceElectronic transport properties of single proteins offer powerful insights into their structure and dynamics. However, the orientation variability of electrode‐attached protein molecules poses a big difficulty in achieving precise electric measurements ...
Ziyi Ju +3 more
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Biomolecules, 2022 Micro/nanoplastics, whether manufactured or resulting from environmental degradation, can enter the body through ingestion, inhalation, or dermal pathways.
Daniela Q. Tran +4 more
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Biphasic modulation of large-fiber excitability accompanied by dynamic nerve-intrinsic immune activation following CFA-induced peripheral inflammation in mice [PDF]
Scientific ReportsPeripheral inflammation is known to enhance pain sensitivity through nociceptive pathways, but its impact on large-diameter myelinated fibers, which mediate touch and proprioception, is less understood.
Shani Berkowitz +10 more
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Abacavir use is associated with increased prothrombin conversion
Frontiers in Immunology, 2023 There is ongoing debate as to whether abacavir (ABC) increases the risk for cardiovascular disease(CVD) in people living with HIV (PLHIV) and the mechanisms underlying this possible association.
Qiuting Yan +11 more
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The Dynamics of Thrombin Formation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2003 The central event of the hemostatic process is the generation of thrombin through the tissue factor pathway. This is a highly regulated, dynamic process in which thrombin itself plays many roles, positively and negatively its production and destruction.
Kenneth G, Mann +2 more
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The Dynamic Structure of Thrombin in Solution [PDF]
Biophysical Journal, 2012 The backbone dynamics of human α-thrombin inhibited at the active site serine were analyzed using R(1), R(2), and heteronuclear NOE experiments, variable temperature TROSY 2D [(1)H-(15)N] correlation spectra, and R(ex) measurements. The N-terminus of the heavy chain, which is formed upon zymogen activation and inserts into the protein core, is highly ...
Fuglestad, Brian +5 more
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