Results 11 to 20 of about 3,246,752 (251)

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay [PDF]

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo, Qiuting Yan, Qiuting Yan, Hugo Ten Cate, Romy De Laat-Kremers, Romy De Laat-Kremers, Bas De Laat, Bas De Laat, Marisa Ninivaggi   +8 more
doaj   +6 more sources

Reference values for thrombin dynamics in platelet rich plasma

Platelets, 2021
Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan, Marisa Ninivaggi, Bas de Laat, Romy M. W. de Laat-Kremers   +3 more
doaj   +7 more sources

Thrombin activity confinement and dense granule release drive the dynamics of arterial thrombus. [PDF]

PLoS Computational Biology
The mechanisms driving spatial heterogeneity of arterial thrombus and its three-stage dynamics are poorly understood. To investigate the potential principles regulating the size of the thrombus core and shell we developed a 3D continuum computational ...
Efim S Bershadsky, Dmitry Y Nechipurenko
doaj   +6 more sources

Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex [PDF]

Scientific Reports, 2021
Serine proteases catalyze a multi-step covalent catalytic mechanism of peptide bond cleavage. It has long been assumed that serine proteases including thrombin carry-out catalysis without significant conformational rearrangement of their stable two-β ...
Riley B. Peacock, Taylor McGrann, Marco Tonelli, Elizabeth A. Komives   +3 more
doaj   +7 more sources

Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin. [PDF]

PLoS ONE, 2015
Biomolecular recognition is crucial in cellular signal transduction. Signaling is mediated through molecular interactions at protein-protein interfaces. Still, specificity and promiscuity of protein-protein interfaces cannot be explained using simplistic
Julian E Fuchs, Roland G Huber, Birgit J Waldner, Ursula Kahler, Susanne von Grafenstein, Christian Kramer, Klaus R Liedl   +6 more
doaj   +6 more sources

Thrombin dynamics

, 2021
Cardiovascular diseases (CVDs) are the number one cause of death globally. In 2012, 17.5 million people died of CVDs, of which 43% were caused by ischemic heart disease and 38% by stroke. Thrombosis plays a pivotal role in the development of ischemic heart disease and stroke. Therefore, the haemostatic system has been one of the main targets of prevent
Kremers, Romy
openaire   +2 more sources

Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies. [PDF]

PLoS ONE, 2011
Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution.
Vivian de Almeira Silva, Maria Thereza Cargnelutti, Guilherme M Giesel, Leonardo C Palmieri, Robson Q Monteiro, Hugo Verli, Luis Mauricio T R Lima   +6 more
doaj   +3 more sources

Personalized modulation of coagulation factors using a thrombin dynamics model to treat trauma-induced coagulopathy [PDF]

npj Systems Biology and Applications, 2021
Current trauma-induced coagulopathy resuscitation protocols use slow laboratory measurements, rules-of-thumb, and clinician gestalt to administer large volumes of uncharacterized, non-tailored blood products.
Damon E. Ghetmiri, Mitchell J. Cohen, Amor A. Menezes   +2 more
doaj   +2 more sources

Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: The thrombin dynamics method has been used as an add-on analysis method for the thrombin generation test over the past years to study the balance between pro- and anticoagulant pathways.
Amalia De Curtis, Romy de Laat-Kremers, Simona Costanzo, Augusto Di Castelnuovo, Marisa Ninivaggi, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas de Laat, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti, Marialaura Bonaccio, Americo Bonanni, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Jos Vermylen, Renzo Pegoraro, Antonio G. Spagnolo, Deodato Assanelli, Livia Rago, Simona Costanzo, Sabatino Orlandi, Teresa Panzera, Augusto Di Castelnuovo, Marialaura Bonaccio, Francesca Bracone, Simona Costanzo, Giuseppe Di Costanzo, Simona Esposito, Alessandro Gialluisi, Anwal Ghulam, Francesco Gianfagna, Martina Morelli, Maria Loreto Muñoz Venegas, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Concetta Civitillo, Alisia Cretella, Sara Magnacca, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Di Costanzo, Martina Morelli, Americo Bonanni   +51 more
doaj   +2 more sources

Deciphering the coagulation profile through the dynamics of thrombin activity [PDF]

Scientific Reports, 2020
AbstractThrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we have named thrombin dynamics. Via this method we are able to exactly measure
de Laat-Kremers, Romy M. W., Yan, Qiuting, Ninivaggi, Marisa, de Maat, Moniek, de Laat, Bas   +4 more
openaire   +7 more sources