Results 31 to 40 of about 18,386 (273)
Pharmaceutics, 2023 Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification.
Irina V. Varizhuk +6 more
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Dynamic allostery in thrombin—a review
Frontiers in Molecular Biosciences, 2023 Thrombin is a serine protease that catalyzes a large number of different reactions including proteolytic cleave of fibrinogen to make the fibrin clot (procoagulant activity), of the protease activated receptors (for cell signaling) and of protein C generating activated protein C (anticoagulant activity). Thrombin has an effector binding site called the
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Anticoagulants and the propagation phase of thrombin generation. [PDF]
PLoS ONE, 2011 The view that clot time-based assays do not provide a sufficient assessment of an individual's hemostatic competence, especially in the context of anticoagulant therapy, has provoked a search for new metrics, with significant focus directed at techniques
Thomas Orfeo +5 more
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Contribution of septins to human platelet structure and function
iScience, 2022 Summary: Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We show that Septin-2 and Septin-9
Oleg V. Kim +5 more
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Investigation of the heparin–thrombin interaction by dynamic force spectroscopy [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015 The interaction between heparin and thrombin is a vital step in the blood (anti)coagulation process. Unraveling the molecular basis of the interactions is therefore extremely important in understanding the mechanisms of this complex biological process.In this study, we use a combination of an efficient thiolation chemistry of heparin, a self-assembled ...
Congzhou, Wang +3 more
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Barrier-protective effects of activated protein C in human alveolar epithelial cells. [PDF]
PLoS ONE, 2013 Acute lung injury (ALI) is a clinical manifestation of respiratory failure, caused by lung inflammation and the disruption of the alveolar-capillary barrier.
Ferranda Puig +6 more
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All Life, 2023 Bu-Shen-Yi-Qi granule (BSYQG), a Chinese herbal formula, has been used for the treatment of ischemic stroke with proven efficacy. The purpose of this study is to evaluate the therapeutic efficacy of BSYQG in neurovascular unit (NVU) and its mechanism of ...
Aihua Liu +6 more
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PLoS ONE, 2020 Platelets upregulate the generation of thrombin and reinforce the fibrin clot which increases the incidence risk of venous thromboembolism (VTE). However, the role of platelets in the pathogenesis of venous cardiovascular diseases remains hard to ...
Anass Bouchnita +4 more
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Percutaneous Thrombin Injection Based on Computational Fluid Dynamics of Femoral Artery Pseudoaneurysms [PDF]
Korean Journal of Radiology, 2021 To analyze the computational fluid dynamics (CFD) of femoral artery pseudoaneurysm (FAP), identify a suitable location and timing for percutaneous thrombin injection (PTI) based on this analysis, and report our clinical experience with the procedure.CFD can be used to analyze the hemodynamics of the human body.
Hyoung-Ho Kim +5 more
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Table_1_Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay.docx
, 2022 BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Qiuting Yan (8695335) +5 more
core +1 more source