Results 51 to 60 of about 3,246,752 (251)

Design of Potent and Controllable Anticoagulants Using DNA Aptamers and Nanostructures

Molecules, 2016
The regulation of thrombin activity offers an opportunity to regulate blood clotting because of the central role played by this molecule in the coagulation cascade. Thrombin-binding DNA aptamers have been used to inhibit thrombin activity.
Abhijit Rangnekar, Jessica A. Nash, Bethany Goodfred, Yaroslava G. Yingling, Thomas H. LaBean   +4 more
doaj   +1 more source

Thrombin-induced cytoskeleton dynamics in spread human platelets observed with fast scanning ion conductance microscopy

Scientific Reports, 2017
Platelets are small anucleate blood cells involved in haemostasis. Platelet activation, caused by agonists such as thrombin or by contact with the extracellular matrix, leads to platelet adhesion, aggregation, and coagulation. Activated platelets undergo
Jan Seifert, Johannes Rheinlaender, Florian Lang, Meinrad Gawaz, Tilman E. Schäffer   +4 more
doaj   +1 more source

Chromogenic anti-Xa test: the ratio between heparin activity units and concentration of apixaban and rivaroxaban

Атеротромбоз, 2020
Introduction. The direct oral anticoagulants (DOC) therapy does not require alaboratory control; however, it may be required to determine the anticoagulationlevel to choose a treatment strategy if alarge bleeding is developing or emergency surgery is ...
E. V. Titaeva, A. B. Dobrovolsky
doaj   +1 more source

The Dynamic Functional Consequences of the Thrombin-Thrombomodulin Interaction [PDF]

Biophysical Journal, 2014
The coagulation cascade is critical to wound healing, but must be well regulated to prevent pathological clot formation. We previously investigated the backbone dynamics of a key component in this cascade, thrombin, and found that the loops surrounding the thrombin active site show dynamics on the ps-ns timescale when the active site is inhibitor-bound,
Handley, Lindsey D., Stearns, Kyle N., Komives, Elizabeth A.   +2 more
openaire   +1 more source

The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models. [PDF]

PLoS ONE, 2013
Clinical evidence suggests that individuals with factor VIII (FVIII) deficiency (hemophilia A) are protected against venous thrombosis, but treatment with recombinant proteins can increase their risk for thrombosis. In this study we examined the dynamics
Abimbola A Onasoga-Jarvis, Karin Leiderman, Aaron L Fogelson, Michael Wang, Marilyn J Manco-Johnson, Jorge A Di Paola, Keith B Neeves   +6 more
doaj   +1 more source

Dynamic affinity chromatography in the separation of sulfated lignins binding to thrombin [PDF]

Journal of Chromatography B, 2012
Sulfated low molecular weight lignins (LMWLs), a mixture of chemo-enzymatically prepared oligomers, have been found to be potent antagonists of coagulation. However, structures that induce anticoagulation remain unidentified. The highly polar sulfate groups on these molecules and the thousands of different structures present in these mixtures make ...
Aiye, Liang, Jay N, Thakkar, Michael, Hindle, Umesh R, Desai   +3 more
openaire   +2 more sources

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin

Blood Advances, 2018
: Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity.
Romy M.W. Kremers, Stéphane Zuily, Hilde Kelchtermans, Tessa C. Peters, Saartje Bloemen, Véronique Regnault, H. Coenraad Hemker, Philip G. de Groot, Denis Wahl, Bas de Laat   +9 more
doaj   +1 more source

Shedding Light on the Molecular Recognition of Sub-Kilodalton Macrocyclic Peptides on Thrombin by Supervised Molecular Dynamics

Frontiers in Molecular Biosciences, 2021
Macrocycles are attractive structures for drug development due to their favorable structural features, potential in binding to targets with flat featureless surfaces, and their ability to disrupt protein–protein interactions. Moreover, large novel highly
Mahdi Hassankalhori, Giovanni Bolcato, Maicol Bissaro, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Probing the Dynamics of Clot-Bound Thrombin at Venous Shear Rates [PDF]

Biophysical Journal, 2017
In closed system models of fibrin formation, exosite-mediated thrombin binding to fibrin contributes to clot stability and is resistant to inhibition by antithrombin/heparin while still susceptible to small, active-site inhibitors. Each molecule of fibrin can bind ∼1.6 thrombin molecules at low-affinity binding sites (Kd = 2.8 μM) and ∼0.3 molecules of
Laura M, Haynes, Thomas, Orfeo, Kenneth G, Mann, Stephen J, Everse, Kathleen E, Brummel-Ziedins   +4 more
openaire   +2 more sources

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source