Results 51 to 60 of about 18,386 (273)
Microheology of fibrin clots [PDF]
, 2012 An active particle tracking microrheology technique has been developed to study the viscoelastic properties of human fibrin and plasma clots. In order to perform microrheology measurements, a magnetic microrheometer device has been adapted and a ...
Allan, Peter
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen
, 2022 The W215A/E217A mutant thrombin is called “anticoagulant thrombin” because its activity toward its procoagulant substrate, fibrinogen, is reduced more than 500-fold whereas in the presence of thrombomodulin (TM) its activity toward its anticoagulant ...
Taylor McGrann +7 more
core +2 more sources
Platelets, 2021 In this work, we present a new method—Thrombodynamics-4D—for the assessment of both plasma and platelet contributions to clotting. Thrombodynamics-4D potentially allows for the determination of plasma or platelet disorders and the effects of various ...
Ekaterina M. Koltsova +10 more
doaj +1 more source
Exploring the Dynamics of Thrombin by NMR [PDF]
, 2013 Thrombin is a tightly regulated serine protease that acts at the terminus of the blood coagulation cascade, performing proteolytic activation of platelets and converting soluble fibrinogen into insoluble fibrin.
Fuglestad, Brian A.
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Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Frontiers in PharmacologyPurposeThe inhibition of thrombin has proven to be an efficacious therapeutic approach for managing cardiovascular disease (CVD), with widespread implementation in clinical settings.
Xiaoyu Chai +12 more
doaj +1 more source
NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation [PDF]
Proceedings of the National Academy of Sciences, 2010 The serine protease thrombin is generated from its zymogen prothrombin at the end of the coagulation cascade. Thrombin functions as the effector enzyme of blood clotting by cleaving several procoagulant targets, but also plays a key role in attenuating the hemostatic response by activating protein C.
Bernhard C, Lechtenberg +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng +16 more
wiley +1 more source
Identification of Allosteric Mechanisms in Thrombin through Molecular Dynamics Simulations / [PDF]
, 2013 Molecular dynamics (MD) simulation, an established method for investigating the internal motions of biomolecules, is applied to thrombin protein, a critical blood coagulation cascade protease with complex, not yet fully understood regulatory mechanisms ...
Gasper, Paul M.
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