Results 71 to 80 of about 18,386 (273)
Protein Dynamics and Allostery in Thrombin, Thrombomodulin, and IkappaBalpha [PDF]
, 2015 Allostery is a critical process that allows for the regulation of proteins : binding of a molecule at one distal, functional site in a protein can cause changes to a different functional site.
Handley, Lindsey Denise
core
Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine
Advanced Materials Interfaces, EarlyView.Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee +3 more
wiley +1 more source
Trypanosoma brucei modifies the tsetse salivary composition, altering the fly feeding behavior that favors parasite transmission. [PDF]
PLoS Pathogens, 2010 Tsetse flies are the notorious transmitters of African trypanosomiasis, a disease caused by the Trypanosoma parasite that affects humans and livestock on the African continent.
Jan Van Den Abbeele +4 more
doaj +1 more source
Hard‐Magnetic Soft Millirobots in Underactuated Systems
Advanced Robotics Research, EarlyView.This review provides a comprehensive overview of hard‐magnetic soft millirobots in underactuated systems. It examines key advances in structural design, physics‐informed modeling, and control strategies, while highlighting the interplay among these domains.
Qiong Wang +4 more
wiley +1 more source
Understanding Russell's viper venom factor V activator's substrate specificity by surface plasmon resonance and in-silico studies. [PDF]
PLoS ONE, 2017 Blood coagulation factor V (FV) is activated either by Factor X or thrombin, cleaving at three different sites viz., Site I (Arg709-Ser710), site II (Arg1018-Thr1019), and site III (Arg1545-Ser1546).
Pradeep K Yadav +3 more
doaj +1 more source
Thrombomodulin Binding to Thrombin Reveals the Backbone Dynamics Required for the Serine Protease Catalytic Mechanism [PDF]
, 2020 The serine protease thrombin plays an essential regulatory role in blood clotting. Prothrombin is converted to the active α-thrombin in response to tissue damage, allowing the enzyme to cleave procoagulative substrates such as fibrinogen and PAR ...
Peacock, Riley B
core
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung +19 more
wiley +1 more source
Involvement of local lamellipodia in endothelial barrier function.
PLoS ONE, 2015 Recently we observed that endothelial cells cultured in tightly confluent monolayers display frequent local lamellipodia, and that thrombin, an agent that increases endothelial permeability, reduces lamellipodia protrusions.
Jerome W Breslin +3 more
doaj +1 more source
Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids
Advanced Science, EarlyView.Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan +19 more
wiley +1 more source