Results 91 to 100 of about 3,246,752 (251)

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

Advanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Thrombin-Induced Il-6 Production in Human Synovial Fibroblasts Is Mediated by Par1, Phospholipase C, Protein Kinase C Alpha, C-Src, Nf- Kappab and P300 Pathway

, 2009
Thrombin is a key factor in the stimulation of fibrin deposition, angiogenesis and proinflammatory processes. Abnormalities in these processes are primary features of rheumatoid arthritis (RA) in synovial tissues.
邱詠証;馮逸卿;賴志河;洪千惠;許弘昌;李土生;楊榮森;符文美;湯智昕, CHIU, YUNG-CHENG;FONG, YI-CHIN;LAI, CHIH-HO;HUNG, CHIEN-HUI;HSU, HORNG-CHAUNG;LEE, TU-SHENG;YANG, RONG-SEN;FU, WEN-MEI;TANG, CHIH- HSIN;TANG, CHIH-HSIN   +1 more
core  

Beyond Charge: Field‐Effect Transistors in Multimodal Biosensing Platforms for Biomolecular Interaction Studies

Advanced Electronic Materials, EarlyView.
This review summarizes the developments in field‐effect transistor (FET)‐based dual‐mode sensor platforms and what can be learned from them. It identifies charge as a crucial factor in biomolecular interactions at interfaces, outlines the challenges of hybrid systems, and highlights their benefits.
Roger Hasler, Ciril Reiner‐Rozman, Christoph Kleber, Jakub Dostalek, Wolfgang Knoll   +4 more
wiley   +1 more source

General Dynamics Corporation Report GA-1612

, 1960
From preface: This report presents the status of design of the MGCR prototype plant as of July 1 ...
General Dynamics Corporation
core  

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Impact of the Position of the Chemically Modified 5-Furyl-2′-Deoxyuridine Nucleoside on the Thrombin DNA Aptamer–Protein Complex: Structural Insights into Aptamer Response from MD Simulations

Molecules, 2019
Aptamers are functional nucleic acids that bind to a range of targets (small molecules, proteins or cells) with a high affinity and specificity. Chemically-modified aptamers are of interest because the incorporation of novel nucleobase components can ...
Preethi Seelam Prabhakar, Richard A. Manderville, Stacey D. Wetmore   +2 more
doaj   +1 more source

Structural Effects of Modifications on Interactions of Thrombin Binding Aptamer with Thrombin: A Molecular Dynamic Study [PDF]

Biophysical Journal, 2021
Walid M. Fahssi, Vibhav Valsangkar, Goh Woon Lee, Sweta Vangaveti, Jia Sheng, Alan A. Chen   +5 more
openaire   +1 more source

The Dynamic Viscoelastic Study of Clotting Reaction in Fibrinogen-Thrombin Systems

Journal of the Society of Materials Science, Japan, 1972
The reaction order in the formation of fibrin network in the fibrinogen-thrombin solution is determined by the analysis of clotting curves obtained by dynamic viscoelasticity measurements at various concentrations of fibrinogen. It is concluded from the rheological point of view that the clotting curves for elastic modulus and loss modulus can be ...
KAIBARA, Makoto, FUKADA, Eiichi
openaire   +2 more sources

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Scientific Reports
Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin.
Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +9 more
doaj   +1 more source