Results 91 to 100 of about 18,386 (273)

Impact of the Position of the Chemically Modified 5-Furyl-2′-Deoxyuridine Nucleoside on the Thrombin DNA Aptamer–Protein Complex: Structural Insights into Aptamer Response from MD Simulations

Molecules, 2019
Aptamers are functional nucleic acids that bind to a range of targets (small molecules, proteins or cells) with a high affinity and specificity. Chemically-modified aptamers are of interest because the incorporation of novel nucleobase components can ...
Preethi Seelam Prabhakar, Richard A. Manderville, Stacey D. Wetmore   +2 more
doaj   +1 more source

Enhanced thrombin generation after cardiopulmonary bypass surgery.

, 2011
Thrombin generation has a key role in the pathophysiology of hemostasis. Research has focused on the intraoperative course of hemostasis, while little is known about postoperative hemostatic activation.
Lison, S;Dietrich, W;Braun, S;Boehm, J;Schuster, T;Englhard, A;Perchuc, A;Spannagl, M;Busley, R
core   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Computational and Molecular Dynamics Insights into the Antithrombotic Mechanism of Triterpenes Derived from Melaleuca bracteata var. Revolution Gold (Myrtaceae)

Molecules
Background/Objectives: Thrombin, a serine protease central to coagulation and platelet activation, remains an important target for the development of safer and more effective antithrombotic agents.
Patrick Appiah-Kubi, Foluso Oluwagbemiga Osunsanmi, Andrew Rowland Opoku, Ashona Singh   +3 more
doaj   +1 more source

The Dynamic Viscoelastic Study of Clotting Reaction in Fibrinogen-Thrombin Systems

Journal of the Society of Materials Science, Japan, 1972
The reaction order in the formation of fibrin network in the fibrinogen-thrombin solution is determined by the analysis of clotting curves obtained by dynamic viscoelasticity measurements at various concentrations of fibrinogen. It is concluded from the rheological point of view that the clotting curves for elastic modulus and loss modulus can be ...
KAIBARA, Makoto, FUKADA, Eiichi
openaire   +2 more sources

Injectable Hydrogel with Rapid Coagulation, Low Swelling, and High Burst Pressure Tolerance Properties for Long‐Term Management of Bleeding Wound

Advanced Science, EarlyView.
An injectable PACmC hydrogel with “rigid island‐flexible chain” architecture is developed, featuring low swelling (49.2% within 7 d), strong wet adhesion (46.5 kPa), and high burst pressure (701 mm Hg), which can achieve rapid hemostasis and long‐term sealing in rabbit and porcine models of hepatic and splenic hemorrhage.
Yang Ouyang, Wenfeng Qiu, Weiwen Liang, Xin Zhang, Weijie Liu, Zixin Chen, Yifei Li, Hui Wang, Youchen Tang, Min Li, Rongkang Huang, Zijian Chen, Binghua Ma   +12 more
wiley   +1 more source

Biophysical characterization of the activity state of thrombin [PDF]

, 2006
The final step of the blood coagulation cascade is the activation of thrombin. Active thrombin cleaves fibrinogen to create fibrin which polymerizes into clots. Regulation of thrombin is imperative to maintaining normal hemostasis.
Koeppe, Julia Rachel
core  

Thio-TBA/thrombin MD simulation results.

, 2014
A: The snapshot taken at 10 ns of RR thio-TBA/thrombin dynamics simulation. The aptamer does not dissociate from the protein, and no significant distortions in GQ structure can be seen. Red dotted lines are H-bonds.
Dmitry Klinov (27657), Nikolay Barinov (525002), Galina Pozmogova (525007), Vladimir Tsvetkov (196287), Dmitry Kaluzhny (196279), Olga Tatarinova (525000), Andrey Chuvilin (525005), Anna Varizhuk (525006), Dmitry Basmanov (525001), Igor Smirnov (525003), Edward Timofeev (525004)   +10 more
core   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Scientific Reports
Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin.
Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +9 more
doaj   +1 more source