Results 41 to 50 of about 18,386 (273)

Design of Potent and Controllable Anticoagulants Using DNA Aptamers and Nanostructures

Molecules, 2016
The regulation of thrombin activity offers an opportunity to regulate blood clotting because of the central role played by this molecule in the coagulation cascade. Thrombin-binding DNA aptamers have been used to inhibit thrombin activity.
Abhijit Rangnekar, Jessica A. Nash, Bethany Goodfred, Yaroslava G. Yingling, Thomas H. LaBean   +4 more
doaj   +1 more source

The Dynamic Functional Consequences of the Thrombin-Thrombomodulin Interaction [PDF]

Biophysical Journal, 2014
The coagulation cascade is critical to wound healing, but must be well regulated to prevent pathological clot formation. We previously investigated the backbone dynamics of a key component in this cascade, thrombin, and found that the loops surrounding the thrombin active site show dynamics on the ps-ns timescale when the active site is inhibitor-bound,
Handley, Lindsey D., Stearns, Kyle N., Komives, Elizabeth A.   +2 more
openaire   +1 more source

Chromogenic anti-Xa test: the ratio between heparin activity units and concentration of apixaban and rivaroxaban

Атеротромбоз, 2020
Introduction. The direct oral anticoagulants (DOC) therapy does not require alaboratory control; however, it may be required to determine the anticoagulationlevel to choose a treatment strategy if alarge bleeding is developing or emergency surgery is ...
E. V. Titaeva, A. B. Dobrovolsky
doaj   +1 more source

The effect of factor VIII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models. [PDF]

PLoS ONE, 2013
Clinical evidence suggests that individuals with factor VIII (FVIII) deficiency (hemophilia A) are protected against venous thrombosis, but treatment with recombinant proteins can increase their risk for thrombosis. In this study we examined the dynamics
Abimbola A Onasoga-Jarvis, Karin Leiderman, Aaron L Fogelson, Michael Wang, Marilyn J Manco-Johnson, Jorge A Di Paola, Keith B Neeves   +6 more
doaj   +1 more source

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin

Blood Advances, 2018
: Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity.
Romy M.W. Kremers, Stéphane Zuily, Hilde Kelchtermans, Tessa C. Peters, Saartje Bloemen, Véronique Regnault, H. Coenraad Hemker, Philip G. de Groot, Denis Wahl, Bas de Laat   +9 more
doaj   +1 more source

Shedding Light on the Molecular Recognition of Sub-Kilodalton Macrocyclic Peptides on Thrombin by Supervised Molecular Dynamics

Frontiers in Molecular Biosciences, 2021
Macrocycles are attractive structures for drug development due to their favorable structural features, potential in binding to targets with flat featureless surfaces, and their ability to disrupt protein–protein interactions. Moreover, large novel highly
Mahdi Hassankalhori, Giovanni Bolcato, Maicol Bissaro, Mattia Sturlese, Stefano Moro   +4 more
doaj   +1 more source

Dynamic affinity chromatography in the separation of sulfated lignins binding to thrombin [PDF]

Journal of Chromatography B, 2012
Sulfated low molecular weight lignins (LMWLs), a mixture of chemo-enzymatically prepared oligomers, have been found to be potent antagonists of coagulation. However, structures that induce anticoagulation remain unidentified. The highly polar sulfate groups on these molecules and the thousands of different structures present in these mixtures make ...
Aiye, Liang, Jay N, Thakkar, Michael, Hindle, Umesh R, Desai   +3 more
openaire   +2 more sources

Probing the Dynamics of Clot-Bound Thrombin at Venous Shear Rates [PDF]

Biophysical Journal, 2017
In closed system models of fibrin formation, exosite-mediated thrombin binding to fibrin contributes to clot stability and is resistant to inhibition by antithrombin/heparin while still susceptible to small, active-site inhibitors. Each molecule of fibrin can bind ∼1.6 thrombin molecules at low-affinity binding sites (Kd = 2.8 μM) and ∼0.3 molecules of
Laura M, Haynes, Thomas, Orfeo, Kenneth G, Mann, Stephen J, Everse, Kathleen E, Brummel-Ziedins   +4 more
openaire   +2 more sources

Fluorescence resonance energy transfer (FRET) spatiotemporal mapping of atypical P38 reveals an endosomal and cytosolic spatial bias

Scientific Reports, 2023
Mitogen-activated protein kinase (MAPK) p38 is a central regulator of intracellular signaling, driving physiological and pathological pathways. With over 150 downstream targets, it is predicted that spatial positioning and the availability of cofactors ...
Jeremy C. Burton, Jennifer Okalova, Neil J. Grimsey   +2 more
doaj   +1 more source

SCREENING OF CLOTTING SYSTEM DISORDERS BY LABORATORY TESTS

Российский кардиологический журнал, 2015
The review takes into consideration the diagnostic significance of the main screening coagulologic tests under the light of modern views on the role of vessel wall, plasma proteins and blood cells in the dynamics of thrombin formation and its activities ...
A. B. Dobrovolsky, E. V. Titaeva
doaj   +1 more source