The Effects of Heparin Binding and Arg596 Mutations on the Conformation of Thrombin–Antithrombin Michaelis Complex, Revealed by Enhanced Sampling Molecular Dynamics Simulations [PDF]
International Journal of Molecular SciencesGabor Balogh +2 more
exaly +2 more sources
Light Chain Mutation Effects on the Dynamics of Thrombin
Journal of Chemical Information and Modeling, 2021 Thrombin plays an important role in the process of hemostasis and blood coagulation. Studies in thrombin can help us find ways to treat cancer because thrombin is able to reduce the characteristic hypercoagulability of cancer. Thrombin is composed of two chains, the light chain and the heavy chain.
Dizhou Wu +2 more
openaire +3 more sources
Citrate anticoagulation and the dynamics of thrombin generation [PDF]
Journal of Thrombosis and Haemostasis, 2007 Sodium citrate has been used as an anticoagulant to stabilize blood and blood products for over 100 years, presumably by sequestering Ca(++) ions in vitro. Anticoagulation of blood without chelation can be achieved by inhibition of the contact pathway by corn trypsin inhibitor (CTI).To evaluate the influence of citrate anticoagulation on the ...
K G, Mann +3 more
openaire +2 more sources
Function and Dynamics of Thrombin by NMR [PDF]
Biophysical Journal, 2012 Thrombin is a serine protease that plays an essential role in the blood-clotting cascade, cleaving soluble fibrinogen to insoluble fibrin and activating platelets. Thrombin is also involved in tissue repair, angiogenesis and inflammation via the activation of the PAR-1 and PAR-3 receptors. In its positive feedback loop, thrombin activates factors XI, V,
Fuglestad, Brian A. +1 more
openaire +1 more source
Scientific Reports, 2021 Factor (F) VIII deficiency causes bleeding in haemophilia A patients because of the reduced formation of procoagulant enzyme thrombin, which is needed to make the blood clot.
Romy M. W. de Laat-Kremers +4 more
doaj +1 more source
Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA)
Molecules, 2021 The thrombin binding aptamer (TBA) is a promising nucleic acid-based anticoagulant. We studied the effects of chemical modifications, such as dendrimer Trebler and NHS carboxy group, on TBA with respect to its structures and thrombin binding affinity ...
Vibhav Valsangkar +7 more
doaj +1 more source
Mathematical modeling of thrombin propagation during blood coagulation [PDF]
Компьютерные исследования и моделирование, 2017 In case of vessel wall damage or contact of blood plasma with a foreign surface, the chain of chemical reactions called coagulation cascade is launched that leading to the formation of a fibrin clot.
Tatiana V Galochkina, Vitaly A Volpert
doaj +1 more source
Probing the Hirudin-Thrombin Interaction by Incorporation of Noncoded amino Acids and Molecular Dynamics Simulation [PDF]
, 2002 Thrombin is a primary target for the development of novel anticoagulants, since it plays two important and opposite roles in hemostasis: procoagulant and anticoagulant.
DE FILIPPIS, VINCENZO +10 more
core +2 more sources
A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability. [PDF]
PLoS ONE, 2018 Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells.
Joana Amado-Azevedo +4 more
doaj +1 more source
NMR reveals a dynamic allosteric pathway in thrombin [PDF]
Scientific Reports, 2017 AbstractAlthough serine proteases are found ubiquitously in both eukaryotes and prokaryotes, and they comprise the largest of all of the peptidase families, their dynamic motions remain obscure. The backbone dynamics of the coagulation serine protease, apo-thrombin (S195M-thrombin), were compared to the substrate-bound form (PPACK-thrombin).
Lindsey D. Handley +6 more
openaire +2 more sources