Dynamics of thrombin-induced exposition of actin on the platelet surface [PDF]
The Ukrainian Biochemical Journal, 2014 Platelets play the key role in thrombosis and are also involved in angiogenesis as well as immune and reparative responses. In the function cascade, platelets undergo a complex cell processing, and subcellular fragments, not detectable in the resting ...
A. A. Tykhomyrov
doaj +3 more sources
Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk [PDF]
Frontiers in Cell and Developmental BiologyPro- and anti-coagulant factors are significantly altered in liver cirrhosis resulting in an increased bleeding and thrombosis risk. The thrombin generation (TG) test often seems unaltered in cirrhosis, indicating that a new hemostatic balance is reached.
Ruth Anne Laura Willems +26 more
doaj +2 more sources
Study of the Differential Activity of Thrombin Inhibitors Using Docking, QSAR, Molecular Dynamics, and MM-GBSA. [PDF]
PLoS ONE, 2015 Non-peptidic thrombin inhibitors (TIs; 177 compounds) with diverse groups at motifs P1 (such as oxyguanidine, amidinohydrazone, amidine, amidinopiperidine), P2 (such as cyanofluorophenylacetamide, 2-(2-chloro-6-fluorophenyl)acetamide), and P3 (such as ...
Karel Mena-Ulecia +2 more
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Computational and Molecular Dynamics Insights into the Antithrombotic Mechanism of Triterpenes Derived from Melaleuca bracteata var. Revolution Gold (Myrtaceae) [PDF]
MoleculesBackground/Objectives: Thrombin, a serine protease central to coagulation and platelet activation, remains an important target for the development of safer and more effective antithrombotic agents.
Patrick Appiah-Kubi +3 more
doaj +2 more sources
Biphasic modulation of large-fiber excitability accompanied by dynamic nerve-intrinsic immune activation following CFA-induced peripheral inflammation in mice [PDF]
Scientific ReportsPeripheral inflammation is known to enhance pain sensitivity through nociceptive pathways, but its impact on large-diameter myelinated fibers, which mediate touch and proprioception, is less understood.
Shani Berkowitz +10 more
doaj +2 more sources
Abacavir use is associated with increased prothrombin conversion
Frontiers in Immunology, 2023 There is ongoing debate as to whether abacavir (ABC) increases the risk for cardiovascular disease(CVD) in people living with HIV (PLHIV) and the mechanisms underlying this possible association.
Qiuting Yan +11 more
doaj +1 more source
Microheology of fibrin clots [PDF]
, 2012 An active particle tracking microrheology technique has been developed to study the viscoelastic properties of human fibrin and plasma clots. In order to perform microrheology measurements, a magnetic microrheometer device has been adapted and a ...
Allan, Peter
core +6 more sources
The clinical utility of thrombin generation [PDF]
, 2011 PhDThe Calibrated Automated Thrombogram (CAT) thrombin generation assay is a technique that allows the characterisation of an individual’s capacity to produce thrombin in response to a procoagulant stimulus. As such it is a global screening test for both
Bevan, Shaun Patrick
core +4 more sources
The Dynamics of Thrombin Formation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2003 The central event of the hemostatic process is the generation of thrombin through the tissue factor pathway. This is a highly regulated, dynamic process in which thrombin itself plays many roles, positively and negatively its production and destruction.
Kenneth G, Mann +2 more
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The Dynamic Structure of Thrombin in Solution [PDF]
Biophysical Journal, 2012 The backbone dynamics of human α-thrombin inhibited at the active site serine were analyzed using R(1), R(2), and heteronuclear NOE experiments, variable temperature TROSY 2D [(1)H-(15)N] correlation spectra, and R(ex) measurements. The N-terminus of the heavy chain, which is formed upon zymogen activation and inserts into the protein core, is highly ...
Fuglestad, Brian +5 more
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