Results 41 to 50 of about 372,410 (315)

Vertical organic synapse expandable to 3D crossbar array

Nature Communications, 2020
Recently, three-terminal synaptic devices have attracted considerable attention owing to their nondestructive weight-update behavior, which is attributed to the completely separated terminals for reading and writing.
Yongsuk Choi, Seyong Oh, C. Qian, Jin-Hong Park, J. Cho   +4 more
semanticscholar   +1 more source

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

TH Open
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation.
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa   +8 more
doaj   +1 more source

Aligning a Synapse [PDF]

Neuron, 2017
Synaptic communication requires alignment of transmitter release sites with transmitter receptors. In this issue of Neuron, Wang et al. (2017) show that α2δ4 subunits link calcium channels to a trans-synaptic complex with glutamate receptors at the visual system's first synapse.
openaire   +2 more sources

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C

Frontiers in Cardiovascular Medicine
BackgroundThe mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.
Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +6 more
doaj   +1 more source

Towards an Understanding of Synapse Formation

Neuron, 2018
Synapses are intercellular junctions specialized for fast, point-to-point information transfer from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal secretes neurotransmitters via a canonical release machinery, while a ...
T. Südhof
semanticscholar   +1 more source

Correction to: Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

BMC Cancer, 2019
Following publication of the original article [1], the authors have re-evaluated the authorship for this article. The updated author group is:
Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im   +10 more
doaj   +1 more source

Coagulation parameters predict COVID-19-related thrombosis in a neural network with a positive predictive value of 98%

Frontiers in Immunology, 2022
Thrombosis is a major clinical complication of COVID-19 infection. COVID-19 patients show changes in coagulation factors that indicate an important role for the coagulation system in the pathogenesis of COVID-19.
Romy de Laat-Kremers, Raf De Jongh, Raf De Jongh, Marisa Ninivaggi, Aernoud Fiolet, Rob Fijnheer, Jasper Remijn, Bas de Laat, Bas de Laat   +8 more
doaj   +1 more source

Astrocyte-derived Interleukin-33 promotes microglial synapse engulfment and neural circuit development

Science, 2018
Call to action The developing brain initially makes more synapses than it needs. With further development, excess synapses are pruned away, leaving mature circuits. Synapses can be eliminated by microglia, which engulf and destroy them. Vainchtein et al.
I. Vainchtein, Gregory Chin, Frances S. Cho, Kevin W. Kelley, John G. Miller, Elliott C. Chien, SA Liddelow, P. Nguyen, Hiromi Nakao-Inoue, Leah C. Dorman, O. Akil, S. Joshita, B. Barres, J. Paz, Ari B. Molofsky, A. Molofsky   +15 more
semanticscholar   +1 more source

The Versatile Synapse [PDF]

Journal of Experimental Biology, 1984
ABSTRACT‘Typically’ chemical synaptic transmission takes place when an influx of calcium ions during a presynaptic nerve impulse triggers exocytosis of neurotransmitter substance from synaptic vesicles. The neurotransmitter diffuses across the synaptic cleft and occupies receptors embedded in the subsynaptic membrane.
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source