Results 21 to 30 of about 29,641 (245)

The Immunological Synapse [PDF]

Cancer Immunology Research, 2003
AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
openaire   +6 more sources

The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling

Haematologica, 2011
Background T-cell activation relies on the assembly of the immunological synapse, a structure tightly regulated by the actin cytoskeleton. The precise role of the Wiskott-Aldrich syndrome protein, an actin cytoskeleton regulator, in linking immunological
Ronan Calvez, Fanny Lafouresse, Julie De Meester, Anne Galy, Salvatore Valitutti, Loïc Dupré   +5 more
doaj   +1 more source

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

BMC Biology, 2011
Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo, Pende Daniela, Cerundolo Vincenzo, Salio Mariolina, Stinchcombe Jane C, Griffiths Gillian M   +5 more
doaj   +1 more source

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

eLife, 2014
T cell receptor (TCR) activation leads to a dramatic reorganisation of both membranes and receptors as the immunological synapse forms. Using a genetic model to rapidly inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic T ...
Misty R Jenkins, Jane C Stinchcombe, Byron B Au-Yeung, Yukako Asano, Alex T Ritter, Arthur Weiss, Gillian M Griffiths   +6 more
doaj   +1 more source

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Nature Communications, 2022
Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological ...
Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig   +14 more
doaj   +1 more source

Action and traction: cytoskeletal control of receptor triggering at the immunological synapse

Frontiers in Immunology, 2016
It is well known that F-actin dynamics drive micron-scale cell shape changes required for migration and immunological synapse formation. In addition, recent evidence points to a more intimate role for the actin cytoskeleton in promoting T cell activation.
Janis K. Burkhardt, William A Comrie
doaj   +1 more source

In vitro Assessment of Immunological Synapse Formation by Flow Cytometry

Bio-Protocol, 2016
In adaptive immune system, formation of immunological synapse between T cells and antigen presenting cells (dendritic cells, B cells, and macrophages) or target cells (tumor cells and viral-infected cells) is critical for the execution of T cell immune ...
Bo-Ra Na, Chang-Duk Jun
doaj   +1 more source

HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral

Frontiers in Immunology, 2014
In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
doaj   +1 more source

Lipid switches in the immunological synapse. [PDF]

J Biol Chem
Adaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell. As a consequence of the T cell receptor interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction known as the ...
Griffiths G, Brügger B, Freund C.
europepmc   +4 more sources

Actin Engine in Immunological Synapse [PDF]

Immune Network, 2012
T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion.
Piragyte, Indre, Jun, Chang-Duk
openaire   +2 more sources