Results 21 to 30 of about 565,531 (300)

Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease [PDF]

Signal Transduction and Targeted Therapy
The immunological synapse (IS) serves as the fundamental architectural framework for direct interactions and secretory crosstalk between immune cells, as well as between immune cells and other cells.
Zheng Chao, Qi Mei, Chunguang Yang, Jing Luo, Peikun Liu, Hao Peng, Xiangdong Guo, Zhinan Yin, Le Li, Zhihua Wang   +9 more
doaj   +3 more sources

Connexin-Mediated Signaling at the Immunological Synapse [PDF]

International Journal of Molecular Sciences, 2020
The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell.
Andres Tittarelli, Maria Alejandra Gleisner, Flavio Salazar-Onfray   +2 more
exaly   +3 more sources

Dynamics and spatial organization of Kv1.3 at the immunological synapse of human CD4+ T cells. [PDF]

Biophys J, 2023
Formation of the immunological synapse (IS) is a key event during initiation of an adaptive immune response to a specific antigen. During this process, a T cell and an antigen presenting cell form a stable contact that allows the T cell to integrate both
Capera J, Jainarayanan A, Navarro-Pérez M, Valvo S, Demetriou P, Depoil D, Estadella I, Kvalvaag A, Felce JH, Felipe A, Dustin ML.   +10 more
europepmc   +2 more sources

The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells. [PDF]

Front Cell Dev Biol, 2021
Dendritic cells (DCs) are considered the most potent antigen-presenting cells. DCs control the activation of T cells (TCs) in the lymph nodes. This process involves forming a specialized superstructure at the DC-TC contact zone called the immunological ...
Rodríguez-Fernández JL, Criado-García O.   +1 more
europepmc   +2 more sources

isMap – immunological synapse map analysis program [PDF]

Frontiers in Immunology
T cell activation is initiated when T cells recognize their cognate antigen on the surface of antigen presenting cells (APCs). This triggers formation of a specialized membrane interface termed the immunological synapse (IS) which governs the spatial ...
Amanda Holstad Singleton, Amanda Holstad Singleton, Anthony Manet, Salvatore Valvo, Salvatore Valvo, Marike Feenstra, Marike Feenstra, Harald Stenmark, Harald Stenmark, Michael L. Dustin, Michael L. Dustin, Audun Kvalvaag, Audun Kvalvaag   +12 more
doaj   +2 more sources

In vitro machine learning-based CAR T immunological synapse quality measurements correlate with patient clinical outcomes. [PDF]

PLoS Comput Biol, 2022
The human immune system consists of a highly intelligent network of billions of independent, self-organized cells that interact with each other. Machine learning (ML) is an artificial intelligence (AI) tool that automatically processes huge amounts of ...
Naghizadeh A, Tsao WC, Hyun Cho J, Xu H, Mohamed M, Li D, Xiong W, Metaxas D, Ramos CA, Liu D.   +9 more
europepmc   +2 more sources

Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse. [PDF]

J Cell Biol, 2021
Dendritic cell (DC) actin dynamics at the immunological synapse with T cells is partially regulated by the WAVE regulatory complex. Absence of DC WAVE leads to reduced actin dynamics, prolonged cell–cell contacts, and impaired T cell priming.
Leithner A, Altenburger LM, Hauschild R, Assen FP, Rottner K, Stradal TEB, Diz-Muñoz A, Stein JV, Sixt M.   +8 more
europepmc   +2 more sources

RBL-2H3 Mast Cell Receptor Dynamics in the Immunological Synapse [PDF]

Biophysica, 2022
The RBL-2H3 mast cell immunological synapse dynamics is often simulated with reaction–diffusion and Fokker–Planck equations. The equations focus on how the cell synapse captures receptors following an immune response, where the receptor capture at the ...
Ming Chih Tsai, Kathrin Spendier
doaj   +2 more sources

Three-Dimensional Single Molecule Localization Microscopy Reveals the Topography of the Immunological Synapse at Isotropic Precision below 15 nm. [PDF]

Nano Lett, 2021
T-cells engage with antigen-presenting cells in search for antigenic peptides and form transient interfaces termed immunological synapses. Synapse topography affects receptor binding rates and the mutual segregation of proteins due to size exclusion ...
Velas L, Brameshuber M, Huppa JB, Kurz E, Dustin ML, Zelger P, Jesacher A, Schütz GJ.   +7 more
europepmc   +2 more sources

Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse. [PDF]

Front Cell Dev Biol, 2021
T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen presented on an antigen-presenting cell (APC) induces the formation of the immune synapse (IS), the convergence of secretory vesicles from T and B lymphocytes toward the centrosome ...
Calvo V, Izquierdo M.
europepmc   +2 more sources