Results 21 to 30 of about 241,841 (240)
Geometrically repatterned immunological synapses uncover formation mechanisms [PDF]
, 2006 The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Michael Meyer-Hermann +5 more
core +2 more sources
Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]
, 2002 Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Nigel John Burroughs +3 more
core +1 more source
Developing T cells form an immunological synapse for passage through the β-selection checkpoint. [PDF]
J Cell Biol, 2021 The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a functional T cell receptor β (TCRβ).
Allam AH +3 more
europepmc +2 more sources
BMC Biology, 2011 Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo +5 more
doaj +1 more source
Action and traction: cytoskeletal control of receptor triggering at the immunological synapse
Frontiers in Immunology, 2016 It is well known that F-actin dynamics drive micron-scale cell shape changes required for migration and immunological synapse formation. In addition, recent evidence points to a more intimate role for the actin cytoskeleton in promoting T cell activation.
Janis K. Burkhardt, William A Comrie
doaj +1 more source
Nature Communications, 2022 Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological ...
Hsin-Fang Chang +14 more
doaj +1 more source
T-Cell activation: a queuing theory analysis at low agonist density [PDF]
, 2006 We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Burroughs, Nigel John, Wedagedera, J. R.
core +1 more source
In vitro Assessment of Immunological Synapse Formation by Flow Cytometry
Bio-Protocol, 2016 In adaptive immune system, formation of immunological synapse between T cells and antigen presenting cells (dendritic cells, B cells, and macrophages) or target cells (tumor cells and viral-infected cells) is critical for the execution of T cell immune ...
Bo-Ra Na, Chang-Duk Jun
doaj +1 more source
HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral
Frontiers in Immunology, 2014 In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
doaj +1 more source
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. [PDF]
PLoS ONE, 2010 RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells,
Hee-Don Chae +4 more
doaj +1 more source