Results 1 to 10 of about 128,344 (306)

Composition and function of the C1b/C1f region in the ciliary central apparatus

Scientific Reports, 2021
Motile cilia are ultrastructurally complex cell organelles with the ability to actively move. The highly conserved central apparatus of motile 9 × 2 + 2 cilia is composed of two microtubules and several large microtubule-bound projections, including the ...
Ewa Joachimiak, Anna Osinka, Hanan Farahat, Bianka Świderska, Ewa Sitkiewicz, Martyna Poprzeczko, Hanna Fabczak, Dorota Wloga   +7 more
doaj   +1 more source

Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells–derived neural rosettes

Scientific Reports, 2023
Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj   +1 more source

The LisH Domain-Containing N-Terminal Fragment is Important for the Localization, Dimerization, and Stability of Katnal2 in Tetrahymena

Cells, 2020
Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated by a less conserved linker.
Ewa Joachimiak, Ewa Waclawek, Michal Niziolek, Anna Osinka, Hanna Fabczak, Jacek Gaertig, Dorota Wloga   +6 more
doaj   +1 more source

Quantifying cilia beat frequency using high‐speed video microscopy: Assessing frame rate requirements when imaging different ciliated tissues

Physiological Reports, 2022
Motile cilia are found in numerous locations throughout our body and play a critical role in various physiological processes. The most commonly used method to assess cilia motility is to quantify cilia beat frequency (CBF) via video microscopy.
Luke Scopulovic, Deanne Francis, Elvis Pandzic, Richard Francis   +3 more
doaj   +1 more source

Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in Tetrahymena Cilia

Cells, 2022
Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules—nine peripheral doublets and two central singlets (9 × 2 + 2 ...
Marta Bicka, Ewa Joachimiak, Paulina Urbanska, Anna Osinka, Anna Konopka, Ewa Bulska, Dorota Wloga   +6 more
doaj   +1 more source

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans [PDF]

, 2006
The diversity of sensory cilia on Caenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles,
Evans, James E., Snow, Joshua J., Gunnarson, Amy L., Ou, Guangshuo, Stahlberg, Henning, McDonald, Kent L., Scholey, Jonathan M.   +6 more
core   +2 more sources

Intraflagellar Transport Proteins as Regulators of Primary Cilia Length

Frontiers in Cell and Developmental Biology, 2021
Primary cilia are small, antenna-like organelles that detect and transduce chemical and mechanical cues in the extracellular environment, regulating cell behavior and, in turn, tissue development and homeostasis.
Wei Wang, Brittany M. Jack, Henry H. Wang, Matthew A. Kavanaugh, Robin L. Maser, Pamela V. Tran   +5 more
doaj   +1 more source

Heat shock induces rapid resorption of primary cilia [PDF]

, 2012
Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar, Baker, Berbari, Boyault, Breunig, Caspary, Corbit, Cotto, Davenport, Fliegauf, Gherman, Han, Haycraft, Kültz, Lange, McGlashan, Meimaridou, Nauli, Ng, Nigg, Overgaard, Pedersen, Pugacheva, Quarmby, Rohatgi, Rosenbaum, Schneider, Seeley, Singla, Taipale, Takaki, Weis, Williams   +32 more
core   +1 more source

Cilia and cilia-associated proteins in cancer [PDF]

Drug Discovery Today: Disease Mechanisms, 2013
The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors.
Tamina, Seeger-Nukpezah, Joy L, Little, Victoria, Serzhanova, Erica A, Golemis   +3 more
openaire   +2 more sources

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
A. K. T. Wann, AC Lin, AJ Espanol, AM Malone, BD Engel, BK Yoder, CA Dinarello, CG Jensen, CM Asleson, D Qian, DA Lee, E Verghese, E Verghese, EJ Michaud, EM Mokrzan, GJ Pazour, H Tukachinsky, I Memon, J Kim, JA Deane, JL Rosenbaum, JM Neugebauer, K Gardner, KJ Palmer, L Schneider, M Barzi, M Cao, M. M. Knight, MA Lancaster, MB Hovater, N Sharma, P Tummala, PA Lefebvre, PV Tran, RY Kwon, S Abdul-Majeed, S Agarwal, S Kim, S Massinen, S Mukhopadhyay, S Pritchard, S Toffoli, SC Goetz, SM Nauli, SR McGlashan, SR McGlashan, SR McGlashan, TT Chowdhury, TY Besschetnova, Y Chen, Y Ou, YH Choi   +51 more
core   +2 more sources