Results 1 to 10 of about 9,840 (198)
PLoS Genetics, 2012 It is generally believed that the last eukaryotic common ancestor (LECA) was a unicellular organism with motile cilia. In the vertebrates, the winged-helix transcription factor FoxJ1 functions as the master regulator of motile cilia biogenesis.
Shubha Vij +9 more
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Cell, 2015 Motile cilia are hair-like organelles that protrude from the cell surface and are conserved throughout eukaryotes. Motile cilia beat rhythmically and function in cellular and organismal locomotion and in driving fluid transport over epithelia. In vertebrates, their roles are varied, and their dysfunction in humans is associated with disease.
Zhou, Feng, Roy, Sudipto
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Purification and Immunostaining of Mouse Ependymal Ciliary Shafts
Bio-Protocol, 2022 Cilia and flagella are microtubule-based hair-like organelles protruding from the surface of most eukaryotic cells, and play essential roles in cell locomotion, left-right asymmetry, embryo development, and tissue homeostasis.
Kai Hao, Xueliang Zhu , Xiumin Yan
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, 2023 This data includes XL/MS and structural models for the Tetrahymena motile cilia interactome.
Caitlyn L. McCafferty +6 more
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Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. [PDF]
PLoS Genetics, 2016 Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct stereotypic microtubule doublet arrangements with non-motile or 'primary' cilia having a 9+0 and ...
Wesley R Lewis +20 more
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Frontiers in Cellular Neuroscience, 2019 In the adult mammalian brain, the apical surface of the subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary cilia originating from rare intermingled neural stem cells (NSCs).
Sara Monaco +5 more
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Motile and non‐motile cilia in human pathology: from function to phenotypes [PDF]
The Journal of Pathology, 2016 AbstractCiliopathies are inherited human disorders caused by both motile and non‐motile cilia dysfunction that form an important and rapidly expanding disease category. Ciliopathies are complex conditions to diagnose, being multisystem disorders characterized by extensive genetic heterogeneity and clinical variability with high levels of lethality ...
Mitchison, Hannah M. +1 more
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eLife, 2023 Cilia, either motile or non-motile (a.k.a primary or sensory), are complex evolutionarily conserved eukaryotic structures composed of hundreds of proteins required for their assembly, structure and function that are collectively known as the ciliome ...
Rebeca Brocal-Ruiz +7 more
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eLife, 2017 Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia ...
Barbara Tavares +12 more
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Electrical Signaling in Motile and Primary Cilia
BioScience, 2014 Cilia are highly conserved for their structure and also for their sensory functions. They serve as antennae for extracellular information. Whether the cilia are motile or not, they respond to environmental mechanical and chemical stimuli and signal to the cell body.
Steven J, Kleene, Judith L, Van Houten
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