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Motile cilia and airway disease [PDF]
Seminars in Cell and Developmental Biology, 2021 A finely regulated system of airway epithelial development governs the differentiation of motile ciliated cells of the human respiratory tract, conferring the body's mucociliary clearance defence system. Human cilia dysfunction can arise through genetic mutations and this is a cause of debilitating disease morbidities that confer a greatly reduced ...
Laure-Emmanuelle Zaragosi +2 more
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Cyclic GMP and Cilia Motility [PDF]
Cells, 2015 Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense.
Todd A. Wyatt
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Ion channels and calcium signaling in motile cilia
eLife, 2015 The beating of motile cilia generates fluid flow over epithelia in brain ventricles, airways, and Fallopian tubes. Here, we patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as a calcium signaling ...
Julia F Doerner +2 more
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Microridge-like structures anchor motile cilia
Nature Communications, 2022 Several tissues contain cells with multiple motile cilia that generate a fluid or particle flow to support development and organ functions; defective motility causes human disease.
Takayuki Yasunaga +13 more
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Motile Cilia: Innovation and Insight From Ciliate Model Organisms
Frontiers in Cell and Developmental Biology, 2019 Ciliates are a powerful model organism for the study of basal bodies and motile cilia. These single-celled protists contain hundreds of cilia organized in an array making them an ideal system for both light and electron microscopy studies.
Brian Bayless, Mark Winey, Winey Mark
exaly +3 more sources
Impact of Motile Ciliopathies on Human Development and Clinical Consequences in the Newborn
Cells, 2021 Motile cilia are hairlike organelles that project outward from a tissue-restricted subset of cells to direct fluid flow. During human development motile cilia guide determination of the left-right axis in the embryo, and in the fetal and neonatal periods
Rachael M. Hyland, Steven L. Brody
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Airway ciliated cells in adult lung homeostasis and COPD
European Respiratory Review, 2023 Cilia are organelles emanating from the cell surface, consisting of an axoneme of microtubules that extends from a basal body derived from the centrioles. They are either isolated and nonmotile (primary cilia), or grouped and motile (motile cilia). Cilia
Laure M.G. Petit +10 more
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Nature Communications, 2022 Motile and non-motile cilia have distinct functions and protein complexes associated with them. Here, the authors show the conserved protein CFAP20 is important for both motile and non-motile cilia and is distinct from other ciliopathy-associated domains
Paul W. Chrystal +29 more
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Mucociliary Wnt signaling promotes cilia biogenesis and beating
Nature Communications, 2023 Motile cilia are thought of as signaling-inert nanomotors. Here, the authors show that motile cilia transduce a Wnt-protein phosphatase 1 signal that regulates cilia biogenesis and ciliary beating in Xenopus embryos and in human airway epithelia.
Carina Seidl +5 more
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Rethinking the cilia hypothesis of hydrocephalus
Neurobiology of Disease, 2022 Dysfunction of motile cilia in ependymal cells has been proposed to be a pathogenic cause of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in hydrocephalus, primarily based on observations of enlarged ventricles in mouse ...
Phan Q. Duy +3 more
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