Results 21 to 30 of about 519 (150)
Motile and non‐motile cilia in human pathology: from function to phenotypes [PDF]
The Journal of Pathology, 2016 AbstractCiliopathies are inherited human disorders caused by both motile and non‐motile cilia dysfunction that form an important and rapidly expanding disease category. Ciliopathies are complex conditions to diagnose, being multisystem disorders characterized by extensive genetic heterogeneity and clinical variability with high levels of lethality ...
Mitchison, Hannah M. +1 more
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eLife, 2023 Cilia, either motile or non-motile (a.k.a primary or sensory), are complex evolutionarily conserved eukaryotic structures composed of hundreds of proteins required for their assembly, structure and function that are collectively known as the ciliome ...
Rebeca Brocal-Ruiz +7 more
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Sensory functions of motile cilia and implication for bronchiectasis [PDF]
Frontiers in Bioscience, 2012 Cilia are specialized organelles that extend from the cell surface into the local environment. Cilia of the airway epithelia are motile to provide mucociliary clearance. On other cells, solitary cilia are specialized to detect chemical or mechanosensory signals.
Raksha, Jain +6 more
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eLife, 2017 Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia ...
Barbara Tavares +12 more
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Axoneme Structure from Motile Cilia [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 The axoneme is the main extracellular part of cilia and flagella in eukaryotes. It consists of a microtubule cytoskeleton, which normally comprises nine doublets. In motile cilia, dynein ATPase motor proteins generate sliding motions between adjacent microtubules, which are integrated into a well-orchestrated beating or rotational motion.
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Motile Cilia of Human Airway Epithelia Are Chemosensory [PDF]
Science, 2009 Beat It Primary cilia are specialized organelles that serve important sensory functions in many different tissues and cells, and defects in their structure and function underlie a variety of genetic diseases. In contrast to primary cilia, motile cilia serve a mechanical function.
Alok S, Shah +4 more
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Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia [PDF]
International Journal of Molecular Sciences, 2021 Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization. Zebrafish have many ciliated organs that include primary cilia as well as motile cilia. Using zebrafish as an animal model helps
Andreia L. Pinto +7 more
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DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. [PDF]
PLoS Genetics, 2016 Heterotaxy, a birth defect involving left-right patterning defects, and primary ciliary dyskinesia (PCD), a sinopulmonary disease with dyskinetic/immotile cilia in the airway are seemingly disparate diseases.
You Li +20 more
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Sensory reception is an attribute of both primary cilia and motile cilia [PDF]
Journal of Cell Science, 2010 A recent cluster of papers has shown that motile cilia in the respiratory and reproductive tracts of humans and other mammals can exhibit sensory functions, a function previously attributed primarily to non-motile primary cilia. This leads to a new paradigm that all cilia and flagella (both motile and primary) can mediate sensory functions.
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The transcriptional signature associated with human motile cilia [PDF]
Scientific Reports, 2019 Abstract Cilia are complex microtubule-based organelles implicated in the aetiology of numerous diseases. Accordingly, many cilia-associated proteins have been described, while those distinguishing cilia subtypes are poorly defined.
Patir, Anirudh +6 more
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