Results 21 to 30 of about 9,840 (198)

Loss of RPGR disrupts motile cilia and causes primary ciliary dyskinesia by affecting F-actin dynamics [PDF]

The Journal of Clinical Investigation
Cilia are cellular organelles that extrude from the surface of various cell types, serving either sensory or motile functions. Retinitis pigmentosa GTPase regulator (RPGR) variants affect both photoreceptor sensory cilia and airway motile cilia, leading ...
Yang Wu, Erika Tavares, Binrun Liang, Wallace B. Wee, Vito Mennella, Han-Chao Feng, Jiaying Cao, Pui Yee Wong, Jiayi Zheng, Mu He, Kirk AJ Stephenson, Liran Hanan Hochma, Janice Min Li, Nan-Peng Chen, Sharon D. Dell, Elise Heon, Zhen Liu   +16 more
doaj   +2 more sources

ARL13B controls male reproductive tract physiology through primary and Motile Cilia [PDF]

Communications Biology
ARL13B is a small regulatory GTPase that controls ciliary membrane composition in both motile cilia and non-motile primary cilia. In this study, we investigated the role of ARL13B in the efferent ductules, tubules of the male reproductive tract essential
Céline Augière, Gabriel Campolina-Silva, Aaran Vijayakumaran, Odara Medagedara, Camille Lavoie-Ouellet, Charles Joly Beauparlant, Arnaud Droit, Ferran Barrachina, Kiera Ottino, Maria Agustina Battistone, Kedar Narayan, Rex Hess, Vito Mennella, Clémence Belleannée   +13 more
doaj   +2 more sources

Primary and motile cilia in the efferent ductules: a role for IFT88 in maintaining male fertility [PDF]

Cellular and Molecular Life Sciences
The efferent ductules are male reproductive tubules that support fertility by reabsorbing fluid and transporting sperm from testis to the epididymis. They are lined with multiciliated cells (MCCs) and reabsorptive primary ciliated cells (RPCCs).
Céline Augière, Louis Hermo, Shirley Ferrier-Tarin, Florence Préfontaine, Mariangela Gentile, Pietro Lupetti, Rex A. Hess, Clémence Belleannée   +7 more
doaj   +2 more sources

Motile Cilia in Female and Male Reproductive Tracts and Fertility [PDF]

Cells
Motile cilia are evolutionarily conserved organelles. In humans, multiciliated cells (MCCs), assembling several hundred motile cilia on their apical surface, are components of the monolayer epithelia lining lower and upper airways, brain ventricles, and ...
Dorota Wloga, Ewa Joachimiak, Anna Osinka, Salman Ahmadi, Sumita Majhi   +4 more
doaj   +2 more sources

Pathogenic KIAA0586/TALPID3 variants are associated with defects in primary and motile cilia [PDF]

iScience
Summary: Pathogenic variants in KIAA0586/TALPID3 are associated with the ciliopathy Joubert syndrome (JS). We report individuals with KIAA0586/TALPID3 variants affected by primary and motile cilia defects leading to JS and chronic destructive airway ...
Jacqueline E. Taudien, Diana Bracht, Heike Olbrich, Sebastian Swirski, Fulvio D’Abrusco, Bert Van der Zwaag, Maike Möller, Thomas Lücke, Norbert Teig, Ulrika Lindberg, Kai Wohlgemuth, Julia Wallmeier, Anja Blanque, Christos Gatsogiannis, Sebastian George, Christoph Jüschke, Marta Owczarek-Lipska, Dorothee Veer, Hester Y. Kroes, Enza Maria Valente, G. Christoph Korenke, Heymut Omran, John Neidhardt   +22 more
doaj   +2 more sources

The transcriptional signature associated with human motile cilia. [PDF]

Sci Rep, 2020
Abstract Cilia are complex microtubule-based organelles implicated in the aetiology of numerous diseases. Accordingly, many cilia-associated proteins have been described, while those distinguishing cilia subtypes are poorly defined.
Patir A, Fraser AM, Barnett MW, McTeir L, Rainger J, Davey MG, Freeman TC.   +6 more
europepmc   +4 more sources

Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo [PDF]

Bioengineering, 2022
Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ventricles.
Huseyin Enes Salman, Nathalie Jurisch-Yaksi, Huseyin Cagatay Yalcin   +2 more
doaj   +2 more sources

Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia [PDF]

Communications Biology
Motile cilia are critical structures that regulate early embryonic development and tissue homeostasis through synchronized ciliary motility. The formation of motile cilia is dependent on precisely controlled sequential processes including the generation,
Moonsup Lee, Christina Carpenter, Yoo-Seok Hwang, Jaeho Yoon, Quanlong Lu, Christopher J. Westlake, Sally A. Moody, Terry P. Yamaguchi, Ira O. Daar   +8 more
doaj   +2 more sources

Neuronal coordination of motile cilia in locomotion and feeding. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2020
Efficient ciliary locomotion and transport require the coordination of motile cilia. Short-range coordination of ciliary beats can occur by biophysical mechanisms. Long-range coordination across large or disjointed ciliated fields often requires nervous system control and innervation of ciliated cells by ciliomotor neurons.
Marinković M, Berger J, Jékely G.
europepmc   +5 more sources

Motile Cilia: Innovation and Insight From Ciliate Model Organisms

Frontiers in Cell and Developmental Biology, 2019
Ciliates are a powerful model organism for the study of basal bodies and motile cilia. These single-celled protists contain hundreds of cilia organized in an array making them an ideal system for both light and electron microscopy studies.
Brian Bayless, Mark Winey
exaly   +3 more sources