Results 11 to 20 of about 9,840 (198)
Assessing motile cilia coverage and beat frequency in mammalian in vitro cell culture tissues [PDF]
Royal Society Open Science, 2023 Cilia density, distribution and beating frequency are important properties of airway epithelial tissues. These parameters are critical in diagnosing primary ciliary dyskinesia and examining in vitro models, including those derived from induced ...
Marta Vila Gonzalez, Pietro Cicuta
exaly +4 more sources
Microridge-like structures anchor motile cilia [PDF]
Nature Communications, 2022 Several tissues contain cells with multiple motile cilia that generate a fluid or particle flow to support development and organ functions; defective motility causes human disease.
Takayuki Yasunaga +13 more
doaj +5 more sources
Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia [PDF]
International Journal of Molecular Sciences, 2021 Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization. Zebrafish have many ciliated organs that include primary cilia as well as motile cilia. Using zebrafish as an animal model helps
Andreia L D N Pinto +2 more
exaly +6 more sources
Motile cilia and airway disease [PDF]
Seminars in Cell and Developmental Biology, 2021 A finely regulated system of airway epithelial development governs the differentiation of motile ciliated cells of the human respiratory tract, conferring the body's mucociliary clearance defence system. Human cilia dysfunction can arise through genetic mutations and this is a cause of debilitating disease morbidities that confer a greatly reduced ...
Laure-Emmanuelle Zaragosi +2 more
exaly +5 more sources
IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans. [PDF]
PLoS Genetics, 2023 Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into the ...
Zeineb Bakey +25 more
doaj +2 more sources
The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision [PDF]
Nature Communications, 2022 Motile and non-motile cilia have distinct functions and protein complexes associated with them. Here, the authors show the conserved protein CFAP20 is important for both motile and non-motile cilia and is distinct from other ciliopathy-associated domains
Paul W. Chrystal +29 more
doaj +2 more sources
The methylome of motile cilia. [PDF]
Mol Biol CellCilia are highly complex motile, sensory, and secretory organelles that contain perhaps 1000 or more distinct protein components, many of which are subject to various posttranslational modifications such as phosphorylation, N-terminal acetylation, and proteolytic processing.
King SM +3 more
europepmc +3 more sources
Cyclic GMP and Cilia Motility [PDF]
Cells, 2015 Motile cilia of the lungs respond to environmental challenges by increasing their ciliary beat frequency in order to enhance mucociliary clearance as a fundamental tenant of innate defense.
Todd A. Wyatt
doaj +3 more sources
The regulatory roles of motile cilia in CSF circulation and hydrocephalus [PDF]
Fluids and Barriers of the CNS, 2021 Background Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities, subarachnoid space, and the spine.
Vijay Kumar +5 more
doaj +2 more sources
Ion channels and calcium signaling in motile cilia
eLife, 2015 The beating of motile cilia generates fluid flow over epithelia in brain ventricles, airways, and Fallopian tubes. Here, we patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as a calcium signaling ...
Julia F Doerner +2 more
doaj +5 more sources