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BICD2 promotes ciliogenesis by facilitating CP110 removal from the mother centriole [PDF]
EMBO ReportsCilia are hair-like organelles that protrude from the cell surface and play vital roles in embryonic development and tissue homeostasis. Removal of centriolar coiled-coil protein 110 (CP110) from the mother centriole is a critical step in ciliogenesis ...
Wenjun Kuang +4 more
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Bi-allelic INTU variants define a ciliopathy disorder characterized by orofacial, digital, and cardiac anomalies [PDF]
HGG AdvancesSummary: The primary cilium is a small organelle that plays key roles in cellular signaling. Defects in primary cilia formation, morphology, and function cause a heterogeneous group of developmental syndromes termed ciliopathies. The inturned planar cell
Rebekah Rushforth +7 more
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Nature Communications, 2019 Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique ...
Sumeda Nandadasa +9 more
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Use of Small-Molecule Inhibitors of CILK1 and AURKA as Cilia-Promoting Drugs to Decelerate Medulloblastoma Cell Replication [PDF]
BiomedicinesBackground/Objective: The primary cilium is the sensory organelle of a cell and a dynamic membrane protrusion during the cell cycle. It originates from the centriole at G0/G1 and undergoes disassembly to release centrioles for spindle formation before a ...
Sean H. Fu +11 more
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Enhanced Ciliogenesis of Human Bronchial Epithelial Cells by Simulated Microgravity [PDF]
LifeSpaceflight induces a wide array of effects on the human body, notably including pathological changes mediated by alterations in gravity. Abnormalities in the formation of primary cilia (ciliogenesis) can lead to cell cycle arrest and decreased ...
Seung Hyun Bang +7 more
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Cells, 2022 Primary cilia help to maintain cellular homeostasis by sensing conditions in the extracellular environment, including growth factors, nutrients, and hormones that are involved in various signaling pathways.
Ji-Eun Bae +15 more
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Ionizing radiation promotes primary ciliogenesis in glioblastoma cells
Fushe yanjiu yu fushe gongyi xuebao, 2021 The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei +5 more
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Frontiers in Cell and Developmental Biology, 2020 Primary cilia are microtubule-based, antenna-like organelles, which are formed in G0 phase and resorbed as cells re-enter the cell cycle. It has been reported that primary cilia can influence the timing of cell cycle progression.
Huadong Jiang +7 more
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CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis
BMC Biology, 2023 Background The axonemal microtubules of primary cilium undergo a conserved protein posttranslational modification (PTM) — polyglutamylation. This reversible procedure is processed by tubulin tyrosine ligase-like polyglutamylases to form secondary ...
Yujuan Wang +6 more
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Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
eLife, 2023 Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites. Pcm1−/−
Emma A Hall +18 more
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