Results 21 to 30 of about 9,240 (177)

Ciliogenesis: Polarity Proteins on the Move [PDF]

Current Biology, 2004
The formation and maintenance of cilia and flagella require a selective and directed transport along the axoneme, a characteristic central bundle of microtubules. Recent evidence suggests an interesting link between the generation of cilia and the protein complexes that establish apico-basal cell polarity.
Bossinger, Olaf, Bachmann, André
openaire   +2 more sources

Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.

PLoS ONE, 2017
Primary cilia are non-motile cilia that serve as cellular antennae for sensing and transducing extracellular signals. In general, primary cilia are generated by cell quiescence signals.
Tomoaki Nagai, Kensaku Mizuno
doaj   +1 more source

A meckelin–filamin A interaction mediates ciliogenesis [PDF]

Human Molecular Genetics, 2011
MKS3, encoding the transmembrane receptor meckelin, is mutated in Meckel-Gruber syndrome (MKS), an autosomal-recessive ciliopathy. Meckelin localizes to the primary cilium, basal body and elsewhere within the cell. Here, we found that the cytoplasmic domain of meckelin directly interacts with the actin-binding protein filamin A, potentially at the ...
Adams, M., Simms, R.J., Abdelhamed, Z., Dawe, H.R., Szymanska, K., Logan, C.V., Wheway, G., Pitt, E., Gull, K., Knowles, M.A., Blair, E., Cross, S.H., Sayer, J.A., Johnson, C.A.   +13 more
openaire   +4 more sources

Phosphorylation and Ubiquitylation Regulate Protein Trafficking, Signaling, and the Biogenesis of Primary Cilia

Frontiers in Cell and Developmental Biology, 2021
The primary cilium is a solitary, microtubule-based membrane protrusion extending from the surface of quiescent cells that senses the cellular environment and triggers specific cellular responses.
Elena A. May, Elena A. May, Tommy J. Sroka, Tommy J. Sroka, David U. Mick, David U. Mick   +5 more
doaj   +1 more source

The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms

Biology Open, 2013
Summary We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells.
Jeanne N. Jodoin, Mohammad Shboul, Todd R. Albrecht, Ethan Lee, Eric J. Wagner, Bruno Reversade, Laura A. Lee   +6 more
doaj   +1 more source

Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

Cell Reports, 2020
Summary: Primary cilium is an antenna-like microtubule-based cellular sensing structure. Abnormal regulation of the dynamic assembly and disassembly cycle of primary cilia is closely related to ciliopathy and cancer.
Mi-Lang Kyun, Sun-Ok Kim, Hee Gu Lee, Jeong-Ah Hwang, Joonsung Hwang, Nak-Kyun Soung, Hyunjoo Cha-Molstad, Sangku Lee, Yong Tae Kwon, Bo Yeon Kim, Kyung Ho Lee   +10 more
doaj   +1 more source

C21orf2 variants causing inherited retinal disease: A review of what we know and a report of two new suspected cases

Clinical Case Reports, 2023
Variants in the C21orf2 (CFAP410) gene have recently been associated with the development of retinitis pigmentosa, an inherited condition characterized by degeneration of the retina.
Meagan Shinbashi, Ann Jewell, Jessica Randolph, Natario Couser   +3 more
doaj   +1 more source

A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility

Frontiers in Cell and Developmental Biology, 2023
Normal function of the C-terminal Eps15 homology domain-containing protein 1 (EHD1) has previously been associated with endocytic vesicle trafficking, shaping of intracellular membranes, and ciliogenesis.
Katrin Meindl, Naomi Issler, Naomi Issler, Sara Afonso, Sara Afonso, Alberto Cebrian-Serrano, Alberto Cebrian-Serrano, Alberto Cebrian-Serrano, Karin Müller, Christina Sterner, Helga Othmen, Helga Othmen, Ines Tegtmeier, Ralph Witzgall, Enriko Klootwijk, Benjamin Davies, Benjamin Davies, Robert Kleta, Richard Warth   +18 more
doaj   +1 more source

Nonredundant roles of DIAPHs in primary ciliogenesis [PDF]

Journal of Biological Chemistry, 2021
Primary cilia are hubs for several signaling pathways, and disruption in cilia function and formation leads to a range of diseases collectively known as ciliopathies. Both ciliogenesis and cilia maintenance depend on vesicle trafficking along a network of microtubules and actin filaments toward the basal body.
Oliva Palander, Adam Lam, Richard F. Collins, Theo J. Moraes, William S. Trimble   +4 more
openaire   +2 more sources

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

eLife, 2020
Mammalian Hedgehog (Hh) signaling plays key roles in embryogenesis and uniquely requires primary cilia. Functional analyses of several ciliogenesis-related genes led to the discovery of the developmental diseases known as ciliopathies.
Saishu Yoshida, Katsuhiko Aoki, Ken Fujiwara, Takashi Nakakura, Akira Kawamura, Kohji Yamada, Masaya Ono, Satomi Yogosawa, Kiyotsugu Yoshida   +8 more
doaj   +1 more source