Results 21 to 30 of about 12,764 (170)
EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase
Nature Communications, 2018 The trichoplein-Aurora A pathway inhibits ciliogenesis in proliferating cells. Here the authors EGFR-mediated phosphorylation of the deubiquitinating enzyme USP8 leads to its activation, and this suppresses trichoplein degradation, allowing inhibition of
Kousuke Kasahara +10 more
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KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts [PDF]
iScienceSummary: Primary cilia are essential signaling organelles that protrude from most cells in the body. Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for ...
Ayoola S. Fasawe +2 more
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Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation [PDF]
Nature CommunicationsWDR44 prevents ciliogenesis initiation by regulating RAB11-dependent vesicle trafficking. Here, we describe male patients with missense and nonsense variants within the WD40 repeats (WDR) of WDR44, an X-linked gene product, who display ciliopathy-related
Andrea Accogli +57 more
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Ciliary Membrane Lipid Homeostasis in Health and Disease. [PDF]
Adv Sci (Weinh)This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Huang Z, Liu YY, Sun H, Liu P.
europepmc +2 more sources
Ionizing radiation promotes primary ciliogenesis in glioblastoma cells
Fushe yanjiu yu fushe gongyi xuebao, 2021 The aim of this study was to investigate the effects of ionizing radiation (IR) on ciliogenesis of human glioblastoma cells. The glioblastoma cell lines M059K and M059J were exposed to X-ray or carbon ion at different doses, and the incidence and length ...
MA Wei +5 more
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ODF2L is a negative regulator of ciliogenesis [PDF]
, 2018 The centrosome is a subcellular organelle whose main role is acting as a microtubule organising centre (MTOC). It consists of two barrel-shaped centrioles surrounded by the pericentriolar matrix.
De Saram, Paulu
core +3 more sources
CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis
BMC Biology, 2023 Background The axonemal microtubules of primary cilium undergo a conserved protein posttranslational modification (PTM) — polyglutamylation. This reversible procedure is processed by tubulin tyrosine ligase-like polyglutamylases to form secondary ...
Yujuan Wang +6 more
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Molecular Brain, 2023 The primary cilium, an antenna-like structure on the cell surface, acts as a mechanical and chemical sensory organelle. Primary cilia play critical roles in sensing the extracellular environment to coordinate various developmental and homeostatic ...
Ji-Eun Bae +17 more
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Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.
PLoS ONE, 2017 Primary cilia are non-motile cilia that serve as cellular antennae for sensing and transducing extracellular signals. In general, primary cilia are generated by cell quiescence signals.
Tomoaki Nagai, Kensaku Mizuno
doaj +1 more source
Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]
, 2009 Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Thomas H. Giddings +9 more
core +1 more source