Results 31 to 40 of about 11,577 (216)

Nonredundant roles of DIAPHs in primary ciliogenesis [PDF]

Journal of Biological Chemistry, 2021
Primary cilia are hubs for several signaling pathways, and disruption in cilia function and formation leads to a range of diseases collectively known as ciliopathies. Both ciliogenesis and cilia maintenance depend on vesicle trafficking along a network of microtubules and actin filaments toward the basal body.
Oliva Palander, Adam Lam, Richard F. Collins, Theo J. Moraes, William S. Trimble   +4 more
openaire   +2 more sources

Phosphorylation and Ubiquitylation Regulate Protein Trafficking, Signaling, and the Biogenesis of Primary Cilia

Frontiers in Cell and Developmental Biology, 2021
The primary cilium is a solitary, microtubule-based membrane protrusion extending from the surface of quiescent cells that senses the cellular environment and triggers specific cellular responses.
Elena A. May, Elena A. May, Tommy J. Sroka, Tommy J. Sroka, David U. Mick, David U. Mick   +5 more
doaj   +1 more source

The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms

Biology Open, 2013
Summary We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells.
Jeanne N. Jodoin, Mohammad Shboul, Todd R. Albrecht, Ethan Lee, Eric J. Wagner, Bruno Reversade, Laura A. Lee   +6 more
doaj   +1 more source

C21orf2 variants causing inherited retinal disease: A review of what we know and a report of two new suspected cases

Clinical Case Reports, 2023
Variants in the C21orf2 (CFAP410) gene have recently been associated with the development of retinitis pigmentosa, an inherited condition characterized by degeneration of the retina.
Meagan Shinbashi, Ann Jewell, Jessica Randolph, Natario Couser   +3 more
doaj   +1 more source

A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility

Frontiers in Cell and Developmental Biology, 2023
Normal function of the C-terminal Eps15 homology domain-containing protein 1 (EHD1) has previously been associated with endocytic vesicle trafficking, shaping of intracellular membranes, and ciliogenesis.
Katrin Meindl, Naomi Issler, Naomi Issler, Sara Afonso, Sara Afonso, Alberto Cebrian-Serrano, Alberto Cebrian-Serrano, Alberto Cebrian-Serrano, Karin Müller, Christina Sterner, Helga Othmen, Helga Othmen, Ines Tegtmeier, Ralph Witzgall, Enriko Klootwijk, Benjamin Davies, Benjamin Davies, Robert Kleta, Richard Warth   +18 more
doaj   +1 more source

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

eLife, 2020
Mammalian Hedgehog (Hh) signaling plays key roles in embryogenesis and uniquely requires primary cilia. Functional analyses of several ciliogenesis-related genes led to the discovery of the developmental diseases known as ciliopathies.
Saishu Yoshida, Katsuhiko Aoki, Ken Fujiwara, Takashi Nakakura, Akira Kawamura, Kohji Yamada, Masaya Ono, Satomi Yogosawa, Kiyotsugu Yoshida   +8 more
doaj   +1 more source

Myh10 Is Upregulated During Ciliogenesis. [PDF]

, 2014
(A) Schematic illustration of selected gene expression analysis during ciliogenesis in time course. (B) Myh10 protein level is upregulated during ciliogenesis. RPE-Mchr1GFP cells serum starved (0.2% FBS) for 0, 1, 2, 6, 12 and 24 hours were collected for
Yanhua Rao (321257), Rui Hao (9775), Tso-Pang Yao (15280), Bin Wang (30851)   +3 more
core   +1 more source

Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis

eLife, 2016
To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific proteins ...
Lei Wang, Kwanwoo Lee, Ryan Malonis, Irma Sanchez, Brian D Dynlacht   +4 more
doaj   +1 more source

Dysfunction of GSK3β disrupts ciliogenesis. [PDF]

, 2015
(A) Schematic model of the acquisition of synchronized mitosis–G0 phase NIH 3T3 cells, treated with double thymidine block, nocodazole (Noc), and the indicated GSK3 inhibitors. (B and C) Inhibition of GSK3 impairs ciliogenesis.
Tingting Zhang (264633), Qing Jiang (197843), Guopeng Wang (720360), Chuanmao Zhang (163797), Boyan Zhang (501940), Wangfei Chi (720361), Gang Wang (36685)   +6 more
core   +1 more source

Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis

Biology Open, 2018
In the intraflagellar transport (IFT) machinery, the IFT-B and IFT-A complexes mediate anterograde and retrograde ciliary protein trafficking, respectively.
Ryota Takei, Yohei Katoh, Kazuhisa Nakayama   +2 more
doaj   +1 more source