Results 31 to 40 of about 12,764 (170)

Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation. [PDF]

, 2012
Primary cilia are cellular appendages important for signal transduction and sensing the environment. Bardet-Biedl syndrome proteins form a complex that is important for several cytoskeleton-related processes such as ciliogenesis, cell migration and ...
D Jenkins, PL Beales, Knight, M, Helen May-Simera, Dagan Jenkins, Anna Diaz-Font, Philip L. Beales, Beales, PL, H May-Simera, Diaz-Font, A, Pravincumar, P, A Diaz-Font, Hernandez-Hernandez, V, May-Simera, H, V Hernandez, P Pravincumar, Victor Hernandez-Hernandez, Priyanka Pravincumar, Jenkins, D, M Knight, Martin Knight   +20 more
core   +1 more source

Phosphorylation and Ubiquitylation Regulate Protein Trafficking, Signaling, and the Biogenesis of Primary Cilia

Frontiers in Cell and Developmental Biology, 2021
The primary cilium is a solitary, microtubule-based membrane protrusion extending from the surface of quiescent cells that senses the cellular environment and triggers specific cellular responses.
Elena A. May, Elena A. May, Tommy J. Sroka, Tommy J. Sroka, David U. Mick, David U. Mick   +5 more
doaj   +1 more source

C21orf2 variants causing inherited retinal disease: A review of what we know and a report of two new suspected cases

Clinical Case Reports, 2023
Variants in the C21orf2 (CFAP410) gene have recently been associated with the development of retinitis pigmentosa, an inherited condition characterized by degeneration of the retina.
Meagan Shinbashi, Ann Jewell, Jessica Randolph, Natario Couser   +3 more
doaj   +1 more source

A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility

Frontiers in Cell and Developmental Biology, 2023
Normal function of the C-terminal Eps15 homology domain-containing protein 1 (EHD1) has previously been associated with endocytic vesicle trafficking, shaping of intracellular membranes, and ciliogenesis.
Katrin Meindl, Naomi Issler, Naomi Issler, Sara Afonso, Sara Afonso, Alberto Cebrian-Serrano, Alberto Cebrian-Serrano, Alberto Cebrian-Serrano, Karin Müller, Christina Sterner, Helga Othmen, Helga Othmen, Ines Tegtmeier, Ralph Witzgall, Enriko Klootwijk, Benjamin Davies, Benjamin Davies, Robert Kleta, Richard Warth   +18 more
doaj   +1 more source

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

eLife, 2020
Mammalian Hedgehog (Hh) signaling plays key roles in embryogenesis and uniquely requires primary cilia. Functional analyses of several ciliogenesis-related genes led to the discovery of the developmental diseases known as ciliopathies.
Saishu Yoshida, Katsuhiko Aoki, Ken Fujiwara, Takashi Nakakura, Akira Kawamura, Kohji Yamada, Masaya Ono, Satomi Yogosawa, Kiyotsugu Yoshida   +8 more
doaj   +1 more source

Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis

eLife, 2016
To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific proteins ...
Lei Wang, Kwanwoo Lee, Ryan Malonis, Irma Sanchez, Brian D Dynlacht   +4 more
doaj   +1 more source

Induction of Ran GTP drives ciliogenesis [PDF]

, 2011
The small GTPase Ran and the importin proteins regulate nucleocytoplasmic transport. New evidence suggests that Ran GTP and the importins are also involved in conveying proteins into cilia.
Martens, Jeffrey R, Sajjan, Uma, Ben Margolis, Margolis, Ben, Shuling Fan, Verhey, Kristen J, Toby W. Hurd, Dishinger, John F, Kristen J. Verhey, Jeffrey R. Martens, Hurd, Toby W, Chia Jen Liu, Eileen L. Whiteman, Uma Sajjan, Whiteman, Eileen L, Liu, Chia Jen, Fan, Shuling, McIntyre, Jeremy C, Jeremy C. McIntyre, John F. Dishinger   +19 more
core   +1 more source

NRF2 and Primary Cilia: An Emerging Partnership

Antioxidants, 2020
When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado, Isabel Lastres-Becker, Antonio Cuadrado, Francesc R. Garcia-Gonzalo   +3 more
doaj   +1 more source

Supplementary Files: Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia

, 2020
Supplementary Files: Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory ...
Maliha Zahid, CeciliaW. Lo, Timothy N. Feinstein, Alex D. Lee, Anthony Oro, Molly Schwartz   +5 more
core   +1 more source

SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis

Cells, 2019
Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during centrosome biogenesis and ciliogenesis. Centriolar satellites are highly dynamic during cell cycle or ciliogenesis and how they are regulated remains ...
Pengtao Wang, Jianhong Xia, Leilei Zhang, Shaoyang Zhao, Shengbiao Li, Haiyun Wang, Shan Cheng, Heying Li, Wenguang Yin, Duanqing Pei, Xiaodong Shu   +10 more
doaj   +1 more source