Results 31 to 40 of about 17,107 (226)
Kinesin-2 family in vertebrate ciliogenesis [PDF]
Proceedings of the National Academy of Sciences, 2012 The differentiation of cilia is mediated by kinesin-driven transport. As the function of kinesins in vertebrate ciliogenesis is poorly characterized, we decided to determine the role of kinesin-2 family motors—heterotrimeric kinesin-II and the homodimeric Kif17 kinesin—in zebrafish cilia.
Chengtian, Zhao +4 more
openaire +2 more sources
eLife, 2016 To elucidate the role of centriolar satellites in ciliogenesis, we deleted the gene encoding the PCM1 protein, an integral component of satellites. PCM1 null human cells show marked defects in ciliogenesis, precipitated by the loss of specific proteins ...
Lei Wang +4 more
doaj +1 more source
The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]
, 2015 Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista +51 more
core +1 more source
Length-dependent disassembly maintains four different flagellar lengths in Giardia. [PDF]
, 2019 With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to evaluate flagellar assembly and length regulation. To determine how four different flagellar lengths are maintained, we used live-cell quantitative imaging ...
Aurrecoechea +69 more
core +2 more sources
Ciliogenesis: Polarity Proteins on the Move [PDF]
Current Biology, 2004 The formation and maintenance of cilia and flagella require a selective and directed transport along the axoneme, a characteristic central bundle of microtubules. Recent evidence suggests an interesting link between the generation of cilia and the protein complexes that establish apico-basal cell polarity.
Bossinger, Olaf, Bachmann, André
openaire +2 more sources
Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis
Biology Open, 2018 In the intraflagellar transport (IFT) machinery, the IFT-B and IFT-A complexes mediate anterograde and retrograde ciliary protein trafficking, respectively.
Ryota Takei +2 more
doaj +1 more source
A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]
, 2011 The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ +3 more
core +2 more sources
VDAC3 and Mps1 negatively regulate ciliogenesis [PDF]
Cell Cycle, 2013 Centrosomes serve to organize new centrioles in cycling cells, whereas in quiescent cells they assemble primary cilia. We have recently shown that the mitochondrial porin VDAC3 is also a centrosomal protein that is predominantly associated with the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes.
Shubhra, Majumder, Harold A, Fisk
openaire +2 more sources
Nonredundant roles of DIAPHs in primary ciliogenesis [PDF]
Journal of Biological Chemistry, 2021 Primary cilia are hubs for several signaling pathways, and disruption in cilia function and formation leads to a range of diseases collectively known as ciliopathies. Both ciliogenesis and cilia maintenance depend on vesicle trafficking along a network of microtubules and actin filaments toward the basal body.
Oliva Palander +4 more
openaire +2 more sources
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]
, 2018 Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre +68 more
core +3 more sources