Results 1 to 10 of about 76,105 (304)
Primary cilia and lipid raft dynamics [PDF]
Open Biology, 2021 Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions.
Yuhei Nishimura +5 more
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Rediscovering Primary Cilia in Pancreatic Islets [PDF]
Diabetes & Metabolism Journal, 2023 Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
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Primary cilia in the mature brain: emerging roles in Alzheimer’s disease pathogenesis [PDF]
Frontiers in Cell and Developmental BiologyPrimary cilia are microtubule-based structures that resemble antennae and function as sensory organelles. Dysfunction of primary cilia has been linked to various age-related conditions.
Alexis Shiying Huang +3 more
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Lengthening primary cilia enhances cellular mechanosensitivity [PDF]
European Cells & Materials, 2017 The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signalling cascades in response to external stimuli.
M Spasic, CR Jacobs
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GPR88 localization to primary cilia in neurons is cell-type specific [PDF]
Life Science AllianceThis is the first demonstration of cell-type specific GPCR localization to primary cilia in vivo in intact brain tissue. GPR88 is an orphan G protein-coupled receptor that regulates dopamine neurotransmission and is a target for neuropsychiatric ...
Yenni H Li Guan +3 more
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Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications [PDF]
Cancer Biology & MedicinePrimary cilia, microtubule-based organelles protruding from the surfaces of most eukaryotic cells, have critical roles in maintaining cellular homeostasis, by sensing, transducing, and transmitting diverse extracellular and intracellular signals through ...
Miaomiao Zheng, Jun Zhou, Yijie Wang
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Application of bioactive materials primary cilia as a novel delivery vehicle [PDF]
Bioactive MaterialsPrimary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm),
Ayan K. Barui +7 more
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Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy [PDF]
iScienceSummary: The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), a sensor of growth signals that control cell growth, has been studied mainly in proliferating cells.
Jong Shin +9 more
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Primary cilia in growth plates orchestrate long bone development [PDF]
Fundamental ResearchThe growth plate plays a crucial role in long bone development and elongation, housing stem cells that contribute to bone formation. This study investigates the role of primary cilia, specialized organelles that regulate stem cell fate, in the ...
Lei Zhang +8 more
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Primary Cilia and Atherosclerosis [PDF]
Frontiers in Physiology, 2021 In artery tree, endothelial function correlates with the distribution of shear stress, a dragging force generated by flowing blood. In laminar shear stress areas, endothelial cells (ECs) are available to prevent atherosclerosis, however, ECs in disturbed shear stress sites are featured with proinflammation and atherogenesis.
Zhi-Mei Wang +3 more
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