Results 1 to 10 of about 42,278 (249)
Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis) [PDF]
Toxins, 2023 Sesquiterpene lactones (SLs), plant-derived metabolites with broad spectra of biological effects, including anti-tumor and anti-inflammatory, hold promise for drug development.
Marina Murillo-Pineda +9 more
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Lengthening primary cilia enhances cellular mechanosensitivity [PDF]
European Cells & Materials, 2017 The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signalling cascades in response to external stimuli.
M Spasic, CR Jacobs
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Fluorescence imaging of beta cell primary cilia
Frontiers in Endocrinology, 2022 Primary cilia are slender cell-surface organelles that project into the intercellular space. In pancreatic beta cells, primary cilia coordinate a variety of cell responses including GPCR signaling, calcium influx, and insulin secretion, along with likely
Zipeng A. Li +3 more
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Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
Osteoarthritis and Cartilage, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Martin M Knight
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Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]
Cellular and Molecular Life Sciences, 2012 Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
Angus K T Wann, Martin M Knight
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Primary cilia in the mature brain: emerging roles in Alzheimer’s disease pathogenesis [PDF]
Frontiers in Cell and Developmental BiologyPrimary cilia are microtubule-based structures that resemble antennae and function as sensory organelles. Dysfunction of primary cilia has been linked to various age-related conditions.
Alexis Shiying Huang +3 more
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GPR88 localization to primary cilia in neurons is cell-type specific [PDF]
Life Science AllianceThis is the first demonstration of cell-type specific GPCR localization to primary cilia in vivo in intact brain tissue. GPR88 is an orphan G protein-coupled receptor that regulates dopamine neurotransmission and is a target for neuropsychiatric ...
Yenni H Li Guan +3 more
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NRF2 and Primary Cilia: An Emerging Partnership [PDF]
Antioxidants, 2020 When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado +3 more
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Emerging Roles of Primary Cilia in Glioma [PDF]
Frontiers in Cellular Neuroscience, 2019 Primary cilia are microtubule-based organelles that are typically present on cells during the G0 or G1-S/G2 phases of the cell cycle. Recent studies of glioblastoma (GBM) biopsies, a brain tumor that is notorious for its aggressive growth and resistance ...
Matthew R. Sarkisian +2 more
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Roles of Primary Cilia in the Developing Brain
Frontiers in Cellular Neuroscience, 2019 Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including ...
Sang Min Park +3 more
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