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The Roles of Primary Cilia in Cardiovascular Diseases [PDF]
Cells, 2018 Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sensory organelles that transmit extracellular clues into intracellular signals for molecular and cellular responses.
Rajasekharreddy Pala +3 more
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Emerging Roles of Primary Cilia in Glioma [PDF]
Frontiers in Cellular Neuroscience, 2019 Primary cilia are microtubule-based organelles that are typically present on cells during the G0 or G1-S/G2 phases of the cell cycle. Recent studies of glioblastoma (GBM) biopsies, a brain tumor that is notorious for its aggressive growth and resistance ...
Matthew R. Sarkisian +2 more
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Assembly of primary cilia. [PDF]
Developmental Dynamics, 2008 Primary cilia are microtubule-based, hair-like sensory organelles present on the surface of most growth-arrested cells in our body. Recent research has demonstrated a crucial role for primary cilia in regulating vertebrate developmental pathways and ...
Christensen, Søren T +7 more
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Primary cilia and lipid raft dynamics [PDF]
Open Biology, 2021 Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions.
Yuhei Nishimura +5 more
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Lengthening primary cilia enhances cellular mechanosensitivity [PDF]
European Cells & Materials, 2017 The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signalling cascades in response to external stimuli.
M Spasic, CR Jacobs
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Fluorescence imaging of beta cell primary cilia [PDF]
Frontiers in Endocrinology, 2022 Primary cilia are slender cell-surface organelles that project into the intercellular space. In pancreatic beta cells, primary cilia coordinate a variety of cell responses including GPCR signaling, calcium influx, and insulin secretion, along with likely
Zipeng A. Li +3 more
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Dynamic regulation of hypothalamic NPY2R-positive primary cilia by nutritional states [PDF]
Frontiers in Cell and Developmental BiologyPrimary cilia are specialized signaling organelles that concentrate selected G protein-coupled receptors and are important in neuronal and metabolic regulation.
Akie Hamamoto +3 more
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Rediscovering Primary Cilia in Pancreatic Islets [PDF]
Diabetes & Metabolism Journal, 2023 Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
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NRF2 and Primary Cilia: An Emerging Partnership [PDF]
Antioxidants, 2020 When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado +3 more
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Primary cilia in the mature brain: emerging roles in Alzheimer’s disease pathogenesis [PDF]
Frontiers in Cell and Developmental BiologyPrimary cilia are microtubule-based structures that resemble antennae and function as sensory organelles. Dysfunction of primary cilia has been linked to various age-related conditions.
Alexis Shiying Huang +3 more
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