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The Roles of Primary Cilia in Cardiovascular Diseases [PDF]
Cells, 2018 Primary cilia are microtubule-based organelles found in most mammalian cell types. Cilia act as sensory organelles that transmit extracellular clues into intracellular signals for molecular and cellular responses.
Rajasekharreddy Pala +3 more
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Primary cilia in the mature brain: emerging roles in Alzheimer’s disease pathogenesis [PDF]
Frontiers in Cell and Developmental BiologyPrimary cilia are microtubule-based structures that resemble antennae and function as sensory organelles. Dysfunction of primary cilia has been linked to various age-related conditions.
Alexis Shiying Huang +3 more
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GPR88 localization to primary cilia in neurons is cell-type specific [PDF]
Life Science AllianceThis is the first demonstration of cell-type specific GPCR localization to primary cilia in vivo in intact brain tissue. GPR88 is an orphan G protein-coupled receptor that regulates dopamine neurotransmission and is a target for neuropsychiatric ...
Yenni H Li Guan +3 more
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Roles of Primary Cilia in the Developing Brain
Frontiers in Cellular Neuroscience, 2019 Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including ...
Sang Min Park +3 more
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Redox Biology, 2019 The primary cilium, which protrudes from the cell surface, is associated with the pathogenesis of various diseases, including acute kidney injury (AKI). Primary cilium length dynamically changes during the progression of diseases.
Min Jung Kong +5 more
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Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications [PDF]
Cancer Biology & MedicinePrimary cilia, microtubule-based organelles protruding from the surfaces of most eukaryotic cells, have critical roles in maintaining cellular homeostasis, by sensing, transducing, and transmitting diverse extracellular and intracellular signals through ...
Miaomiao Zheng, Jun Zhou, Yijie Wang
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Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy [PDF]
iScienceSummary: The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), a sensor of growth signals that control cell growth, has been studied mainly in proliferating cells.
Jong Shin +9 more
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Calprotectin: An Ignored Biomarker of Neutrophilia in Pediatric Respiratory Diseases
Children, 2021 Calprotectin (CP) is a non-covalent heterodimer formed by the subunits S100A8 (A8) and S100A9 (A9). When neutrophils become activated, undergo disruption, or die, this abundant cytosolic neutrophil protein is released.
Grigorios Chatziparasidis, Ahmad Kantar
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Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis)
Toxins, 2023 Sesquiterpene lactones (SLs), plant-derived metabolites with broad spectra of biological effects, including anti-tumor and anti-inflammatory, hold promise for drug development.
Marina Murillo-Pineda +9 more
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Fluorescence imaging of beta cell primary cilia
Frontiers in Endocrinology, 2022 Primary cilia are slender cell-surface organelles that project into the intercellular space. In pancreatic beta cells, primary cilia coordinate a variety of cell responses including GPCR signaling, calcium influx, and insulin secretion, along with likely
Zipeng A. Li +3 more
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