Results 1 to 10 of about 284,518 (203)
Synaptic Wnt/GSK3β Signaling Hub in Autism [PDF]
, 2016 Indexación: ScopusHundreds of genes have been associated with autism spectrum disorders (ASDs) and the interaction of weak and de novo variants derive from distinct autistic phenotypes thus making up the "spectrum." The convergence of these variants in ...
Avila, M.E. +2 more
core +1 more source
Potential Roles of the WNT Signaling Pathway in Amyotrophic Lateral Sclerosis
Cells, 2021 The WNT signaling pathway plays an important role in the physiological and pathophysiological processes of the central nervous system and the neurodegenerative disease amyotrophic lateral sclerosis (ALS).
Xin Jiang +10 more
doaj +1 more source
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode [PDF]
, 2008 The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2^+ ectoderm gives rise not only to the otic placode but also to the surrounding cranial epidermis, and that Wnt ...
Groves, Andrew K. +3 more
core
The Casein Kinase I Family in Wnt Signaling [PDF]
, 2001 The canonical Wnt-signaling pathway is critical for many aspects of development, and mutations in components of the Wnt pathway are carcinogenic. Recently, sufficiency tests identified casein kinase Iϵ (CKIϵ) as a positive component of the canonical Wnt ...
Graff, Jonathan M. +2 more
core +1 more source
Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. [PDF]
PLoS ONE, 2015 WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner.
Michaela Bayerlová +5 more
doaj +1 more source
Targeting the Wnt pathways for therapies [PDF]
, 2014 The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance.
Blagodatski, A. +2 more
core +1 more source
Neuroglobin promotes neurogenesis through Wnt signaling pathway [PDF]
Cell Death & Disease, 2018 AbstractNeuroglobin (Ngb) has been demonstrated by our lab and others to be neuroprotective against neurological disorders including stroke. However, the roles of Ngb in neurogenesis remain elusive. Neurogenesis can occur in adulthood and can be induced by pathological conditions in the brain such as stroke, and significantly contributes to functional ...
Yu, Zhanyang +5 more
openaire +2 more sources
Model Reduction on the Wnt Pathway Leads to Biological Adaptation [PDF]
, 2017 Complex systems are an unavoidable problem in the field of biology. One of the ways that scientists have tried to overcome this problem is by building mathematical models—manageable representations designed to look at specific physical phenomena. The Wnt
Gaza, Casie, Transtrum, Mark K.
core +2 more sources
Frizzled Proteins are bona fide G Protein-Coupled Receptors [PDF]
, 2009 Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controlling multiple steps in organism development and highly conserved in evolution. Misactivation of the Wnt/Frizzled signaling is cancerogenic.
Silke Buestorf, Vladimir L. Katanaev
core +1 more source
Role of microRNAs in regulation of WNT signaling pathway in urothelial and prostate cancers
Egyptian Journal of Medical Human Genetics, 2022 Background Urothelial cancer (UC) and prostate cancer (PCa) are the most common cancers among men with a high ratio of mortality in advanced-stages.
Mehdi Montazer +3 more
doaj +1 more source