Results 1 to 10 of about 200,393 (308)
Promising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt Signaling
Frontiers in Pharmacology, 2016 Canonical Wnt signaling pathway, also known as Wnt/β-catenin signaling pathway, is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration and differentiation.
Amnani Aminuddin, Pei Yuen Ng
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Cell Communication and SignalingThe Wnt/β-catenin signaling pathway is crucial for embryonic development and adult tissue homeostasis. Dysregulation of Wnt signaling is linked to various developmental anomalies and diseases, notably cancer.
Shin Ae Oh +5 more
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Cell & Bioscience, 2012 The Wnt signaling pathway was initially discovered for its role in tumorigenesis and the development of Drosophila and other eukaryotic organisms. The key effector of this pathway, the bipartite transcription factor β-cat/TCF, is formed by free β-catenin
Ip Wilfred, Chiang Yu-ting, Jin Tianru
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Lentiviral vectors to probe and manipulate the Wnt signaling pathway. [PDF]
PLoS ONE, 2010 The Wnt signaling pathway plays key roles in development, adult tissue homeostasis and stem cell maintenance. Further understanding of the function of Wnt signaling in specific cell types could benefit from lentiviral vectors expressing reporters for the
Christophe Fuerer, Roel Nusse
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Wnt Signaling in Atherosclerosis: Mechanisms to Therapeutic Implications
BiomedicinesAtherosclerosis is a vascular disease in which inflammation plays a pivotal role. Receptor-mediated signaling pathways regulate vascular inflammation and the pathophysiology of atherosclerosis.
Rizwana Afroz, Julie E. Goodwin
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Linchuang shenzangbing zazhi, 2017 Objective To evaluate the effects of Wnt signaling pathways on the CXCR4 expression of bone marrow mesenchymal stem cells(BMSCs),and to investigate the possible regulation mechanisms of the Wnt signaling pathways on the migration ability of BMSCs.Methods
SUN Ji-ping +4 more
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Role of the Wnt/β-catenin signaling pathway in the development of HCC
Frontiers in ImmunologyAbnormalities in the Wnt/β-catenin pathway promote the development of hepatocellular carcinoma (HCC). Mutations in CTNNB1, which encodes β-catenin, are frequently found in clinical HCC samples, as are loss-of-function mutations in signaling pathway ...
Bo Lin, Mengsen Li, Mengsen Li
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The Wnt signaling pathways and cell adhesion
Frontiers in Bioscience, 2012 In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis.
Amin, N., Vincan, Elizabeth
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Wnt signaling pathways in urological cancers: past decades and still growing
Molecular Cancer, 2012 The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers ...
Majid Shahana +2 more
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Biomolecules & BiomedicineThe Wnt signaling pathway is one of the most important and critical signaling pathways for maintaining cellular functions, such as cell proliferation and differentiation.
Jiayi Song +7 more
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