Results 1 to 10 of about 1,449,284 (254)
Wnt signaling pathways in urological cancers: past decades and still growing
Molecular Cancer, 2012 The Wnt signaling pathway is involved in a wide range of embryonic patterning events and maintenance of homeostasis in adult tissues. The pathological role of the Wnt pathway has emerged from studies showing a high frequency of specific human cancers ...
Majid Shahana +2 more
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Advancement of Wnt signal pathway and the target of breast cancer
Open Life Sciences, 2016 Wnt/β-catenin signaling has been proved to play an important role in the development and promotion of cancer metastasis. The activation of Wnt signals can lead to duplicating, updating, metastasizing and relapsing.
Liang Quan +3 more
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Cellular Physiology and Biochemistry, 2017 Background/Aims: Neurotensin (NTS), an intestinal hormone, is profoundly implicated in cancer progression through binding its primary receptor NTSR1. The conserved Wnt/β-Catenin pathway regulates cell proliferation and differentiation via activation of ...
Hualiang Xiao +4 more
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WNT signaling in cancer: molecular mechanisms and potential therapies
Molecular BiomedicineThe WNT signaling pathway, a fundamental molecular network regulating cell proliferation, differentiation, and stemness, plays a critical role in tumorigenesis, cancer progression, and therapeutic resistance. Given its crucial regulatory roles in tumors,
Jiaqi Liang +4 more
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Unraveling the crosstalk: circRNAs and the wnt signaling pathway in cancers of the digestive system
Non-coding RNA ResearchCircular RNA (circRNA) is a unique type of noncoding RNA molecule characterized by its closed-loop structure. Functionally versatile, circRNAs play pivotal roles in gene expression regulation, protein activity modulation, and participation in cell ...
Yu Zhang +3 more
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Wnt/β-catenin signaling pathway: an attractive potential therapeutic target in osteosarcoma
Frontiers in OncologyOsteosarcoma (OS) is the most common bone malignancy in children and adolescents, and although current neoadjuvant chemotherapy has shown efficacy against OS, the long-term survival rate for patients with OS remains low, highlighting the need to find ...
Yi Ding, Yi Ding, Qin Chen, Qin Chen
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Cell Communication and SignalingThe Wnt/β-catenin signaling pathway is crucial for embryonic development and adult tissue homeostasis. Dysregulation of Wnt signaling is linked to various developmental anomalies and diseases, notably cancer.
Shin Ae Oh +5 more
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Frontiers in Veterinary ScienceIntroductionOne of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes.
Kriti Ahuja +5 more
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HeliyonThe WNT/β-catenin signaling pathway plays crucial roles in tumorigenesis and relapse, metastasis, drug resistance, and tumor stemness maintenance. In most tumors, the WNT/β-catenin signaling pathway is often aberrantly activated.
Xi Zhao +6 more
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Linchuang shenzangbing zazhi, 2017 Objective To evaluate the effects of Wnt signaling pathways on the CXCR4 expression of bone marrow mesenchymal stem cells(BMSCs),and to investigate the possible regulation mechanisms of the Wnt signaling pathways on the migration ability of BMSCs.Methods
SUN Ji-ping +4 more
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