Results 1 to 10 of about 206,629 (264)
Updating the Wnt pathways [PDF]
Bioscience Reports, 2014 In the three decades since the discovery of the Wnt1 proto-oncogene in virus-induced mouse mammary tumours, our understanding of the signalling pathways that are regulated by the Wnt proteins has progressively expanded. Wnts are involved in an complex signalling network that governs multiple biological processes and cross-talk with multiple additional ...
Yu, J, Virshup, D.M
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The functional roles of the circRNA/Wnt axis in cancer
Molecular Cancer, 2022 CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway.
Chen Xue +6 more
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Frontiers in Oncology, 2021 BackgroundIn Cervical cancer (CC), in addition to HPV infection, the most relevant alteration during CC initiation and progression is the aberrant activation of Wnt/β-catenin pathway.
Samuel Trujano-Camacho +10 more
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Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt–Wnt Situation [PDF]
Frontiers in Immunology, 2017 Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogenic Gram-positive bacterium, is the cause of Tuberculosis, a major worldwide human infectious disease. The innate immune system is the first host defense against M. tuberculosis. The recognition of this pathogen is mediated by several classes of pattern recognition receptors (PRRs ...
Tomás Villaseñor +5 more
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Evolution of the Wnt Pathways [PDF]
, 2008 Wnt proteins mediate the transduction of at least three major signaling pathways that play central roles in many early and late developmental decisions. They control diverse cellular behaviors, such as cell fate decisions, proliferation, and migration, and are involved in many important embryological events, including axis specification, gastrulation ...
Croce, Jenifer, Mcclay, David
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Wnt pathway antagonists and angiogenesis [PDF]
Protein & Cell, 2010 Dysregulation of the Wnt pathway has been extensively studied in multiple diseases, including some angiogenic disorders. Wnt signaling activation is a major stimulator in pathological angiogenesis and thus, Wnt antagonists are believed to have therapeutic potential for neovascular disorders.
Bin, Zhang, Jian-Xing, Ma
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The Wnt Pathway in Mood Disorders [PDF]
Current Neuropharmacology, 2012 To review the evidence of the involvement of the Wnt signalling pathway in mood disorders and in the action of drugs used to treat these disorders.We performed a careful PubMed search using as keywords all possible terms relevant to the Wnt pathway and crossing them with each of four areas, i.e., developmental effects, behavioural effects, mood ...
SANI, Gabriele +20 more
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Wnt signal transduction pathways [PDF]
Organogenesis, 2008 The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting ...
Yuko, Komiya, Raymond, Habas
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Targeting the Wnt pathways for therapies [PDF]
Molecular and Cellular Therapies, 2014 The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance. Namely, improper activation of this pathway is carcinogenic in many tissues, most notably in the colon, liver and the breast.
Blagodatski, A. +2 more
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Aquaculture Reports, 2023 We previously found that squalene may influence immunity of grouper by affecting the Wnt/β-Catenin signaling pathway, but the exact mechanism is uncertain.
Xiaobo Yan +8 more
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