Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors [PDF]
Acta Pharmacologica Sinica, 2018 Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical and economic burdens worldwide. Wnt signaling pathways play an important role in developmental processes such as tissue patterning, cell differentiation and cell division.
Wei Eric Wang +2 more
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Wnt Pathway-Targeted Therapy in Gastrointestinal Cancers: Integrating Benchside Insights with Bedside Applications [PDF]
CellsThe Wnt signaling pathway is critical in the onset and progression of gastrointestinal (GI) cancers. Anomalies in this pathway, often stemming from mutations in critical components such as adenomatous polyposis coli (APC) or β-catenin, lead to ...
Anirudh Nayak +5 more
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Inhibitors of the Wnt pathway in osteoporosis: Mechanisms of action and potential as therapeutic targets [PDF]
Biomolecules & BiomedicineThe Wnt signaling pathway is one of the most important and critical signaling pathways for maintaining cellular functions, such as cell proliferation and differentiation.
Jiayi Song +7 more
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Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Ovarian cancer is a malignant tumor of the female reproductive system with the highest mortality, and involves the aberrant regulation of multiple molecular signaling pathways.
ZHOU Wanzhen, TENG Yincheng
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The Role of WNT Pathway Mutations in Cancer Development and an Overview of Therapeutic Options
Cells, 2023 It is well established that mutations in the canonical WNT-signalling pathway play a major role in various cancers. Critical to developing new therapeutic strategies is understanding which cancers are driven by WNT pathway activation and at what level ...
Wibke Groenewald +2 more
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Molecular Cancer, 2022 Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults.
Hui Zhao +7 more
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The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Huelsken, J., Behrens, J.
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Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma
Nature Communications, 2023 The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials.
Jing Hao +8 more
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The Wnt/β-catenin signalling pathway in Haematological Neoplasms
Biomarker Research, 2022 Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt
Siwei Yu, Ruyue Han, Runliang Gan
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Regulation of Avian Leukosis Virus Subgroup J Replication by Wnt/β-Catenin Signaling Pathway
Viruses, 2021 Wnt/β-catenin signaling is a highly conserved pathway related to a variety of biological processes in different cells. The regulation of replication of various viruses by Wnt/β-catenin signaling pathway has been reported. However, the interaction between
Dandan Qiao +7 more
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