Results 11 to 20 of about 1,355,729 (196)
Prostate cancer stem cell fate: β-catenin and the Wnt pathway [PDF]
, 2010 A major problem in prostate cancer is the high relapse rate post therapy. This is believed to be due to the presence of a small number of prostate cancer stem cells within a tumour.
Jakoby, Sarah
core +6 more sources
WNT signalling in joint repair and homeostasis [PDF]
, 2011 PhDDisruption of the Wnt canonical signalling leads to the development of osteoarthritis both in human and in mice but the underlying molecular mechanisms are poorly understood.
Nalesso, Giovanna
core +4 more sources
Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]
, 2008 [eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core +6 more sources
The functional roles of the circRNA/Wnt axis in cancer
Molecular Cancer, 2022 CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway.
Chen Xue +6 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundIn Cervical cancer (CC), in addition to HPV infection, the most relevant alteration during CC initiation and progression is the aberrant activation of Wnt/β-catenin pathway.
Samuel Trujano-Camacho +10 more
doaj +1 more source
Evolution of the Wnt Pathways [PDF]
, 2008 Wnt proteins mediate the transduction of at least three major signaling pathways that play central roles in many early and late developmental decisions. They control diverse cellular behaviors, such as cell fate decisions, proliferation, and migration, and are involved in many important embryological events, including axis specification, gastrulation ...
Croce, Jenifer, Mcclay, David
openaire +3 more sources
Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt–Wnt Situation [PDF]
Frontiers in Immunology, 2017 Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogenic Gram-positive bacterium, is the cause of Tuberculosis, a major worldwide human infectious disease. The innate immune system is the first host defense against M. tuberculosis. The recognition of this pathogen is mediated by several classes of pattern recognition receptors (PRRs ...
Tomás Villaseñor +5 more
openaire +2 more sources
Wnt pathway antagonists and angiogenesis [PDF]
Protein & Cell, 2010 Dysregulation of the Wnt pathway has been extensively studied in multiple diseases, including some angiogenic disorders. Wnt signaling activation is a major stimulator in pathological angiogenesis and thus, Wnt antagonists are believed to have therapeutic potential for neovascular disorders.
Bin, Zhang, Jian-Xing, Ma
openaire +2 more sources
Targeting the Wnt pathways for therapies [PDF]
Molecular and Cellular Therapies, 2014 The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance. Namely, improper activation of this pathway is carcinogenic in many tissues, most notably in the colon, liver and the breast.
Blagodatski, A. +2 more
openaire +4 more sources
Aquaculture Reports, 2023 We previously found that squalene may influence immunity of grouper by affecting the Wnt/β-Catenin signaling pathway, but the exact mechanism is uncertain.
Xiaobo Yan +8 more
doaj +1 more source