Results 1 to 10 of about 5,615,576 (203)
Genes and Diseases, 2023 Wnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing
Kevin Qin +20 more
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Molecular Cancer, 2022 Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults.
Hui Zhao +7 more
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Wnt signaling and cancer. [PDF]
Genes & Development, 2000 The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately
P. Polakis
semanticscholar +3 more sources
Oncogene, 2016 Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt ...
T. Zhan, Niklas Rindtorff, M. Boutros
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WNT Signaling in Melanoma [PDF]
International Journal of Molecular Sciences, 2020 WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer.
A. Gajos-Michniewicz, M. Czyż
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Bone ResearchWnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life ...
Lifang Hu +3 more
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Wnt signaling in cancer. [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. From the earliest observation that Wnt overexpression could lead to malignant transformation of mouse mammary tissue to the most recent genetic discoveries gleaned from tumor genome sequencing, the Wnt pathway continues to evolve as a central mechanism in cancer ...
P. Polakis
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WNT Signaling in Disease [PDF]
Cells, 2019 Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development.
L. Ng +7 more
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WNT signaling in cancer: molecular mechanisms and potential therapies [PDF]
Molecular BiomedicineThe WNT signaling pathway, a fundamental molecular network regulating cell proliferation, differentiation, and stemness, plays a critical role in tumorigenesis, cancer progression, and therapeutic resistance. Given its crucial regulatory roles in tumors,
Jiaqi Liang +4 more
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Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers
International Journal of Molecular Sciences, 2020 The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes.
Ju-Won Kim +2 more
exaly +2 more sources