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A New Wave of Targeting ‘Undruggable’ Wnt Signaling for Cancer Therapy: Challenges and Opportunities
Cells, 2023 Aberrant Wnt signaling activation is frequently observed in many cancers. The mutation acquisition of Wnt signaling leads to tumorigenesis, whereas the inhibition of Wnt signaling robustly suppresses tumor development in various in vivo models.
Woo-Jung Park, Moon Jong Kim
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WNT Signaling in Melanoma [PDF]
International Journal of Molecular Sciences, 2020 WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical ...
Anna Gajos-Michniewicz, Malgorzata Czyz
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Genes and DiseasesWnt signaling plays a major role in regulating cell proliferation and differentiation. The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing
Kevin Qin +20 more
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Wnt signaling in liver regeneration, disease, and cancer [PDF]
Clinical and Molecular Hepatology, 2023 The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer.
Gengyi Zou, Jae-Il Park
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WormBook, 2005 The use of Wnt ligands for signaling between cells is a conserved feature of metazoan development. Activation of Wnt signal transduction pathways upon ligand binding can regulate diverse processes including cell proliferation, migration, polarity, differentiation and axon outgrowth.
Ille, F., Sommer, L.
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Frontiers in Physiology, 2021 Exercise initiates systemic adaptation to promote health and prevent various lifestyle-related chronic diseases. Emerging evidence suggests that circulating exosomes mediate some of the beneficial effects of exercise via the transfer of microRNAs between
Kitti Garai +13 more
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Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men [PDF]
Diabetes & Metabolism Journal, 2020 BackgroundSouth Asians generally have an unfavourable metabolic phenotype compared with white Caucasians, including central obesity and insulin resistance.
Laura G.M. Janssen +10 more
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Molecular Cancer, 2022 Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults.
Hui Zhao +7 more
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The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Huelsken, J., Behrens, J.
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Diseases of Wnt signaling [PDF]
Reviews in Endocrine and Metabolic Disorders, 2006 The Wnt signaling pathways play fundamental roles in the differentiation, proliferation, death and function of many cells and as a result are involved in critical developmental, growth and homeostatic processes in animals. There are four currently known pathways of Wnt signaling; the so-called canonical or Wnt/beta-catenin pathway, the Wnt/Ca(+2 ...
Mark L, Johnson, Nalini, Rajamannan
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