Results 11 to 20 of about 1,133,912 (305)
WNT Signaling in Disease [PDF]
Cells, 2019 Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans.
Li Ng +7 more
openaire +4 more sources
Advanced Functional Materials, EarlyView.A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Castro-Hinojosa C +7 more
europepmc +2 more sources
A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling [PDF]
, 2013 Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small molecules of natural origin.
Crawford, Alexander D +8 more
core +4 more sources
Wnt signaling in atherosclerosis [PDF]
European Journal of Pharmacology, 2015 Atherosclerosis is a disease of the vascular wall that forms the basis for a large spectrum of pathologies of various organs and tissues. Although massive research efforts in the last decades have yielded valuable information about its underlying molecular mechanisms, this has not led to a translation into effective therapeutic interventions that can ...
Blankesteijn, W. Matthijs +1 more
openaire +3 more sources
Wnt Signaling in the Niche [PDF]
Cell, 2008 There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic ...
Suda, Toshio, Arai, Fumio
openaire +2 more sources
Adipogenesis and WNT signalling [PDF]
Trends in Endocrinology & Metabolism, 2009 An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated.
Christodoulides, C +3 more
openaire +2 more sources
An Overview of Potential Therapeutic Agents Targeting WNT/PCP Signaling
, 2021 Since the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms.
Jin Wang +5 more
core +1 more source
Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development
Organogenesis, 2023 It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling ...
Yuhan Song +4 more
doaj +1 more source
Frontiers in Physiology, 2019 Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in
Kitti Garai +15 more
doaj +1 more source
Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. [PDF]
PLoS ONE, 2016 In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis.
Ruishuang Geng +5 more
doaj +1 more source