Results 11 to 20 of about 336,645 (300)

Wnt signalling: conquering complexity [PDF]

Development, 2018
ABSTRACT The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs, zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the way. Here, we specifically highlight the instrumental role that developmental biology has played throughout. We take the reader on a journey, starting
Katrin E. Wiese, Roel Nusse, Renée van Amerongen   +2 more
openaire   +4 more sources

WNT Signaling in Melanoma [PDF]

International Journal of Molecular Sciences, 2020
WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical ...
Anna Gajos-Michniewicz, Malgorzata Czyz
openaire   +2 more sources

Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. [PDF]

PLoS ONE, 2016
In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis.
Ruishuang Geng, Teppei Noda, Joanna F Mulvaney, Vincent Y W Lin, Albert S B Edge, Alain Dabdoub   +5 more
doaj   +1 more source

Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development

Organogenesis, 2023
It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling ...
Yuhan Song, Fujie Song, Xuan Xiao, Zhifeng Song, Shangfeng Liu   +4 more
doaj   +1 more source

Artificial Neural Network Correlation and Biostatistics Evaluation of Physiological and Molecular Parameters in Healthy Young Individuals Performing Regular Exercise

Frontiers in Physiology, 2019
Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in
Kitti Garai, Kitti Garai, Zoltan Adam, Zoltan Adam, Robert Herczeg, Emese Katai, Emese Katai, Tamas Nagy, Tamas Nagy, Szilard Pal, Attila Gyenesei, Judit E. Pongracz, Judit E. Pongracz, Marta Wilhelm, Krisztian Kvell, Krisztian Kvell   +15 more
doaj   +1 more source

Nkd1 functions as a passive antagonist of Wnt signaling. [PDF]

PLoS ONE, 2013
Wnt signaling is involved in many aspects of development and in the homeostasis of stem cells. Its importance is underscored by the fact that misregulation of Wnt signaling has been implicated in numerous diseases, especially colorectal cancer.
Diane Angonin, Terence J Van Raay
doaj   +1 more source

Wnt signaling [PDF]

WormBook, 2005
The use of Wnt ligands for signaling between cells is a conserved feature of metazoan development. Activation of Wnt signal transduction pathways upon ligand binding can regulate diverse processes including cell proliferation, migration, polarity, differentiation and axon outgrowth.
openaire   +2 more sources

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]

, 2019
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna, Goh, Ryan, Kong, Xiangyu, Liu, Lizhong, Warmflash, Aryeh   +4 more
core   +1 more source

Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]

, 2016
Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W, Hart, Kevin C, Nelson, William James, Pruitt, Beth L, Sim, Joo Yong   +4 more
core   +2 more sources

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source