Results 21 to 30 of about 5,645,262 (348)
Diseases of Wnt signaling [PDF]
Reviews in Endocrine and Metabolic Disorders, 2006 The Wnt signaling pathways play fundamental roles in the differentiation, proliferation, death and function of many cells and as a result are involved in critical developmental, growth and homeostatic processes in animals. There are four currently known pathways of Wnt signaling; the so-called canonical or Wnt/beta-catenin pathway, the Wnt/Ca(+2 ...
Mark L, Johnson, Nalini, Rajamannan
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Wnt signaling in atherosclerosis [PDF]
European Journal of Pharmacology, 2015 Atherosclerosis is a disease of the vascular wall that forms the basis for a large spectrum of pathologies of various organs and tissues. Although massive research efforts in the last decades have yielded valuable information about its underlying molecular mechanisms, this has not led to a translation into effective therapeutic interventions that can ...
Blankesteijn, W. Matthijs +1 more
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WNT signaling and cancer stemness
Essays in Biochemistry, 2022 Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks.
Masuko Katoh, M. Katoh
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Wnt Signaling in the Niche [PDF]
Cell, 2008 There is much interest in understanding the signals in the bone marrow niche that keep hematopoietic stem cells (HSCs) in a quiescent state. In the current issue of Cell Stem Cell, Fleming et al. (2008) report that blocking Wnt signaling in the niche increases the number of proliferating HSCs and reduces their ability to reconstitute the hematopoietic ...
Suda, Toshio, Arai, Fumio
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Adipogenesis and WNT signalling [PDF]
Trends in Endocrinology & Metabolism, 2009 An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated.
Christodoulides, C +3 more
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LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
Frontiers in Cell and Developmental Biology, 2021 The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren, Jiongcheng Chen, Youhua Liu
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WNT Signaling in Neuroblastoma [PDF]
Cancers, 2019 The term WNT (wingless-type MMTV integration site family) signaling comprises a complex molecular pathway consisting of ligands, receptors, coreceptors, signal transducers and transcriptional modulators with crucial functions during embryonic development, including all aspects of proliferation, morphogenesis and differentiation.
Becker, Juergen, Wilting, Joerg
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Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. [PDF]
PLoS ONE, 2016 In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis.
Ruishuang Geng +5 more
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Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development
Organogenesis, 2023 It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling ...
Yuhan Song +4 more
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Frontiers in Physiology, 2019 Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in
Kitti Garai +15 more
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