Results 21 to 30 of about 209,276 (265)
WormBook, 2005 The use of Wnt ligands for signaling between cells is a conserved feature of metazoan development. Activation of Wnt signal transduction pathways upon ligand binding can regulate diverse processes including cell proliferation, migration, polarity, differentiation and axon outgrowth.
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Wnt signaling in myogenesis [PDF]
Trends in Cell Biology, 2012 The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage.
Julia, von Maltzahn +3 more
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The Role of Wnt and R-spondin in the Stomach During Health and Disease
Biomedicines, 2019 The Wnt signaling pathway is one of the most prominent developmental signals. In addition to its functions in development, there is emerging evidence that it is also crucial for various organ functions in adult organisms, where Wnt signaling controls ...
Anne-Sophie Fischer, Michael Sigal
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Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. [PDF]
PLoS ONE, 2015 WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner.
Michaela Bayerlová +5 more
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Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction
Cell Reports, 2019 Summary: Wnt signaling affects fundamental development pathways and, if aberrantly activated, promotes the development of cancers. Wnt signaling is modulated by different factors, but whether the mitochondrial energetic state affects Wnt signaling is ...
Roberto Costa +19 more
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Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Nature Communications, 2016 Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous ...
Patrizia Cammareri +28 more
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A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
Oncogenesis, 2021 The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron +9 more
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WNT Signaling in Disease [PDF]
Cells, 2019 Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans.
Li Ng +7 more
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Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis
Frontiers in Cell and Developmental Biology, 2021 Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and reside in various tissues, including bone marrow and adipose tissue.
Twan J. J. de Winter +2 more
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Cell Reports, 2014 Summary: WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency.
Jason Ross +8 more
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