Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. [PDF]
PLoS ONE, 2015 WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner.
Michaela Bayerlová +5 more
doaj +1 more source
Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]
, 2014 In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier +17 more
core +1 more source
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma
Nature Communications, 2016 Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous ...
Patrizia Cammareri +28 more
doaj +1 more source
The Role of Wnt and R-spondin in the Stomach During Health and Disease
Biomedicines, 2019 The Wnt signaling pathway is one of the most prominent developmental signals. In addition to its functions in development, there is emerging evidence that it is also crucial for various organ functions in adult organisms, where Wnt signaling controls ...
Anne-Sophie Fischer, Michael Sigal
doaj +1 more source
Running Against the Wnt: How Wnt/β-Catenin Suppresses Adipogenesis
Frontiers in Cell and Developmental Biology, 2021 Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and reside in various tissues, including bone marrow and adipose tissue.
Twan J. J. de Winter +2 more
doaj +1 more source
The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.
Annual Review of Biochemistry, 2022 The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the ...
E. Y. Rim, H. Clevers, R. Nusse
semanticscholar +1 more source
Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]
, 2014 Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728) +40 more
core +1 more source
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
Molecular Cancer, 2020 Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer progression.
Xiufang Xu +3 more
semanticscholar +1 more source
Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction
Cell Reports, 2019 Summary: Wnt signaling affects fundamental development pathways and, if aberrantly activated, promotes the development of cancers. Wnt signaling is modulated by different factors, but whether the mitochondrial energetic state affects Wnt signaling is ...
Roberto Costa +19 more
doaj +1 more source
A CRISPR knockout screen reveals new regulators of canonical Wnt signaling
Oncogenesis, 2021 The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the ...
Tamar Evron +9 more
doaj +1 more source