Results 41 to 50 of about 1,133,912 (305)

Wnt signaling and cancer [PDF]

Genes & Development, 2000
The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately lead to the identification of minimal expression profiles that will serve as common denominators in
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CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability

Cancer Biology & Medicine, 2020
Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase 1 (CK1), other kinases affecting Wnt/β-catenin signaling remain to be defined.
Danmin Ou, Lin Chen, Jiang He, Zhuoxian Rong, Jie Gao, Zhi Li, Liyu Liu, Feiyu Tang, Jiang Li, Yuezhen Deng, Lunquan Sun   +10 more
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β-Arrestin interacts with the beta/gamma subunits of trimeric G-proteins and dishevelled in the Wnt/Ca(2+) pathway in xenopus gastrulation. [PDF]

PLoS ONE, 2014
β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin ...
Katharina Seitz, Verena Dürsch, Jakub Harnoš, Vitezslav Bryja, Marc Gentzel, Alexandra Schambony   +5 more
doaj   +1 more source

Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]

, 2014
Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728), Osborn Daniel P. S., Beales, PL, Daniel P. S. Osborn (519727), Fiona McMurray, Derek Stemple (183414), McMurray, F, Stemple Derek, Roccasecca, RM, Barroso, I, Philip L. Beales (492737), Osborn, DP, Inês Barroso (2144), Hernandez-Hernandez, V, Mukherjee, S, Derek Stemple, Cox, R, Philip L Beales, Victor Hernandez-Hernandez, Stemple, D, Sonia Christou-Savina (519731), Christou-Savina, S, Barroso Inês, Sriparna Mukherjee, Mukherjee Sriparna, Roccasecca Rosa Maria, Cox Roger, Sonia Christou-Savina, Hernandez-Hernandez Victor, Victor Hernandez-Hernandez (519729), Fiona McMurray (106290), Rosa Maria Roccasecca, Sriparna Mukherjee (519730), Beales Philip L., Daniel P S Osborn, Inês Barroso, McMurray Fiona, Osborn, DPS, Roger Cox, Christou-Savina Sonia, Roger Cox (73899)   +40 more
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High throughput genomic screen identifies multiple factors that promote cooperative Wnt signaling. [PDF]

PLoS ONE, 2013
Previous studies have demonstrated that certain Wnt ligands can promote high levels of cooperative signaling in a cell type specific manner. To explore the underlying mechanism of this cooperative Wnt signaling, we performed a high-throughput screen of ...
Mayumi F Miller, Ethan David Cohen, Julie E Baggs, John B Hogenesch, Edward E Morrisey   +4 more
doaj   +1 more source

Differentiation of the brain vasculature : the answer came blowing by the Wnt [PDF]

, 2010
Vascularization of the vertebrate brain takes place during embryonic development from a preformed perineural vascular plexus. As a consequence of the intimate contact with neuroectodermal cells the vessels, which are entering the brain exclusively via ...
Liebner, Stefan, Plate, Karl, Stefan Liebner, Karl H Plate   +3 more
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Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
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Wnt Signaling in Bone

Clinical Pediatric Endocrinology, 2010
Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases.
Kubota, Takuo, Michigami, Toshimi, Ozono, Keiichi   +2 more
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Axing Wnt signals [PDF]

Cell Research, 2011
Wnt signaling is a highly conserved and context-dependent signal transduction pathway that belongs to the so-called morphogens. Wnt signals are instrumental during development, but also play a central role in tissue homeostasis. For instance, in the intestine Wnt signaling is crucial for both stem cell maintenance and proliferation in the transient ...
de Sousa E Melo, Felipe, Medema, Jan Paul   +1 more
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Wnt Signaling in Angiogenesis [PDF]

Current Drug Targets, 2008
Although progress has been made in understanding the role of growth factors and their receptors in angiogenesis, little is known about how the Wnt family of growth factors function in the vasculature. Wnts are multifunctional factors that act through the frizzled receptors to regulate proliferation, apoptosis, branching morphogenesis, inductive ...
Nancy L, Parmalee, Jan, Kitajewski
openaire   +2 more sources