Results 51 to 60 of about 5,645,262 (348)
Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]
, 2012 Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W. +11 more
core +1 more source
Cell Reports, 2014 Summary: WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency.
Jason Ross +8 more
doaj +1 more source
Experimental and Molecular Medicine, 2020 Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt ...
Youn-Sang Jung, Jae-Il Park
semanticscholar +1 more source
Wnt/β-catenin signaling: components, mechanisms, and diseases
Developmental Cell, 2009 Signaling by the Wnt family of secreted glycolipoproteins via the transcription co-activator β-catenin controls embryonic development and adult homeostasis. Here we review recent progresses in this so-called canonical Wnt signaling pathway.
Bryan T. MacDonald, K. Tamai, Xi He
semanticscholar +1 more source
Cancer Biology & Medicine, 2020 Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase 1 (CK1), other kinases affecting Wnt/β-catenin signaling remain to be defined.
Danmin Ou +10 more
doaj +1 more source
The Interplay of WNT and PPARγ Signaling in Vascular Calcification [PDF]
, 2020 Vascular calcification (VC), the ectopic deposition of calcium phosphate crystals in the vessel wall, is one of the primary contributors to cardiovascular death.
Blankesteijn, W. Matthijs +6 more
core +1 more source
High throughput genomic screen identifies multiple factors that promote cooperative Wnt signaling. [PDF]
PLoS ONE, 2013 Previous studies have demonstrated that certain Wnt ligands can promote high levels of cooperative signaling in a cell type specific manner. To explore the underlying mechanism of this cooperative Wnt signaling, we performed a high-throughput screen of ...
Mayumi F Miller +4 more
doaj +1 more source
Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
Life Science Alliance, 2021 Autocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation. Wnt signaling is crucial for proper development, tissue homeostasis and cell cycle regulation.
Yu-Chih Lin +9 more
doaj +1 more source
Wnt Signaling in Angiogenesis [PDF]
Current Drug Targets, 2008 Although progress has been made in understanding the role of growth factors and their receptors in angiogenesis, little is known about how the Wnt family of growth factors function in the vasculature. Wnts are multifunctional factors that act through the frizzled receptors to regulate proliferation, apoptosis, branching morphogenesis, inductive ...
Nancy L, Parmalee, Jan, Kitajewski
openaire +2 more sources
Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G. +5 more
core +1 more source