Results 61 to 70 of about 1,133,912 (305)

Wnt Signaling in the Gastrointestinal Tract in Health and Disease

Physiologia, 2023
Wnt signaling involves multiple pathways that contribute to organ development, cell fate, inflammation, and normal stem cell renewal and maintenance.
Negar Taheri, Egan L. Choi, Vy Truong Thuy Nguyen, Abhishek Chandra, Yujiro Hayashi   +4 more
doaj   +1 more source

Rethinking WNT signalling [PDF]

Nature, 2018
The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of regulation for the WNT signalling pathway during limb development. The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of ...
Jessica A, Lehoczky, Clifford J, Tabin
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Wnt/β-catenin signaling pathway inhibits the proliferation and apoptosis of U87 glioma cells via different mechanisms. [PDF]

PLoS ONE, 2017
The Wnt signaling pathway is necessary for the development of the central nervous system and is associated with tumorigenesis in various cancers. However, the mechanism of the Wnt signaling pathway in glioma cells has yet to be elucidated. Small-molecule
Liyang Gao, Bing Chen, Jinhong Li, Fan Yang, Xuecheng Cen, Zhuangbing Liao, Xiao'ao Long   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

Bone Research
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life ...
Lifang Hu, Wei Chen, Airong Qian, Yi-Ping Li   +3 more
doaj   +1 more source

Wnt/β-catenin signaling within multiple cell types dependent upon kramer regulates Drosophila intestinal stem cell proliferation

iScience
Summary: The gut epithelium is subject to constant renewal, a process reliant upon intestinal stem cell (ISC) proliferation that is driven by Wnt/β-catenin signaling.
Hongyan Sun, Adnan Shami Shah, Din-Chi Chiu, Alessandro Bonfini, Nicolas Buchon, Jeremy M. Baskin   +5 more
doaj   +1 more source

Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. [PDF]

PLoS ONE, 2010
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3.
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa   +15 more
doaj   +1 more source

Mechanisms of the Wnt Pathways as a Potential Target Pathway in Atherosclerosis

Journal of Lipid and Atherosclerosis, 2023
The proteins of the Wnt family are involved in a variety of physiological processes by means of several canonical and noncanonical signaling pathways. Wnt signaling has been recently identified as a major player in atherogenesis.
Anastasia V. Poznyak, Vasily N. Sukhorukov, Mikhail A. Popov, Yegor S Chegodaev, Anton Y. Postnov, Alexander N. Orekhov   +5 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source