Results 71 to 80 of about 1,133,912 (305)
Frontiers in Endocrinology, 2023 BackgroundNon-obstructive azoospermia (NOA) is the most severe type that leads to 1% of male infertility. Wnt signaling governs normal sperm maturation.
Shengjie Zeng +5 more
doaj +1 more source
WNT Signaling and Lymphocyte Development [PDF]
Cell, 2002 Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to control early lymphopoiesis.
Wetering, M. van de +2 more
openaire +3 more sources
Cellular and molecular effects of early pregnancy on mammary epithelial cell subpopulations in mice and their potential relevance for breast cancer protection [PDF]
, 2013 The breast cancer protective effect of an early pregnancy is well established in both humans and rodents, but the underlying mechanism is unclear. Since breast cancers are thought to originate from distinct mammary epithelial cell subtypes, we studied ...
Meier-Abt, Fabienne
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A novel bidirectional positive feedback loop between Wnt/ -catenin and EGFR/ERK: role of context-specific signalling crosstalk in modulating epithelial tissue regeneration [PDF]
, 2014 By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin constitutes the lynchpin between cell:cell contact and transcriptional regulation of proliferation to co-ordinate epithelial tissue homeostasis and ...
Kirkwood, Lisa A. +2 more
core +3 more sources
Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells [PDF]
, 2006 Swiss Cancer League, Swiss National Science Foundation and SNSF NCCR Molecular Oncology ProgrammeBackground: The Wnt signaling pathway is activated by mutations in the APC and beta-catenin genes in many types of human cancer.
Homicsko, Krisztian +19 more
core +2 more sources
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Genes and DiseasesThe evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non ...
Michael Yu +18 more
doaj +1 more source
Wnt signalling: conquering complexity [PDF]
Development, 2018 ABSTRACT The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs, zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the way. Here, we specifically highlight the instrumental role that developmental biology has played throughout. We take the reader on a journey, starting
Katrin E. Wiese +2 more
openaire +4 more sources