Results 81 to 90 of about 5,645,262 (348)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Wnt/β-catenin signaling within multiple cell types dependent upon kramer regulates Drosophila intestinal stem cell proliferation

iScience
Summary: The gut epithelium is subject to constant renewal, a process reliant upon intestinal stem cell (ISC) proliferation that is driven by Wnt/β-catenin signaling.
Hongyan Sun, Adnan Shami Shah, Din-Chi Chiu, Alessandro Bonfini, Nicolas Buchon, Jeremy M. Baskin   +5 more
doaj   +1 more source

Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. [PDF]

PLoS ONE, 2010
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3.
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa   +15 more
doaj   +1 more source

Wnt Signaling in Cardiac Remodeling and Heart Failure

, 2017
Wnt signaling plays an essential role during development, but is also activated in diseases as diverse as neurodegeneration, osteoporosis, and cancer. Accumulating evidence demonstrates that Wnt signaling is also activated during cardiac remodeling and ...
Stylianidis, Vasili, Sandner, Peter, Blankesteijn, W. Matthijs, Hermans, Kevin C. M., Bauersachs, Johann, Butler, Javed   +5 more
core   +1 more source

A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions:Potential Relevance to Cerebral Small Vessel Disease [PDF]

, 2020
Key pathological features of cerebral small vessel disease (cSVD) include impairment of the blood brain barrier (BBB) and the progression of white matter lesions (WMLs) amongst other structural lesions, leading to the clinical manifestations of cSVD. The
Fulton, Daniel, Blankesteijn, W. Matthijs, Foulquier, Sebastien; id_orcid, Daniel Fulton, Ahmed, Zubair, Foulquier, Sébastien, Zubair Ahmed, Manukjan, Narek, Fulton, Daniel; id_orcid, W. Matthijs Blankesteijn, Narek Manukjan, Sébastien Foulquier, Ahmed, Zubair; id_orcid   +12 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Wnt signaling in development and tissue homeostasis

Development, 2018
The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis.
Z. Steinhart, S. Angers
semanticscholar   +1 more source

Wnt/β-catenin signaling in cancers and targeted therapies

Signal Transduction and Targeted Therapy, 2021
Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence, advancement of malignant progression ...
F. Yu, Changhao Yu, Feifei Li, Yanqin Zuo, Yitian Wang, L. Yao, Chen-zhou Wu, Chenglin Wang, L. Ye   +8 more
semanticscholar   +1 more source

Wnt Signaling in Bone

Clinical Pediatric Endocrinology, 2010
Wnt signaling is involved not only in embryonic development but also in maintenance of homeostasis in postnatal tissues. Multiple lines of evidence have increased understanding of the roles of Wnt signaling in bone since mutations in the LRP5 gene were identified in human bone diseases.
Kubota, Takuo, Michigami, Toshimi, Ozono, Keiichi   +2 more
openaire   +3 more sources

WNT Signaling and Lymphocyte Development [PDF]

Cell, 2002
Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to control early lymphopoiesis.
Wetering, M. van de, Lau, W. de, Clevers, J.C.   +2 more
openaire   +3 more sources