Results 81 to 90 of about 336,645 (300)
The recent progress of peptide regulators for the Wnt/β-catenin signaling pathway
Frontiers in Medicine, 2023 Wnt signaling plays an important role in many biological processes such as stem cell self-renewal, cell proliferation, migration, and differentiation.
Nan Zhang +6 more
doaj +1 more source
Making sense of Wnt signaling—linking hair cell regeneration to development [PDF]
, 2015 Wnt signaling is a highly conserved pathway crucial for development and homeostasis of multicellular organisms. Secreted Wnt ligands bind Frizzled receptors to regulate diverse processes such as axis patterning, cell division, and cell fate specification.
Alan G. Cheng +2 more
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway. [PDF]
PLoS ONE, 2016 Wnt/β-catenin signaling pathway plays essential roles in mammalian development and tissue homeostasis. MicroRNAs (miRNAs) are a class of regulators involved in modulating this pathway.
Tanyu Hu +9 more
doaj +1 more source
The Wnt signalling pathway [PDF]
Journal of Cell Science, 2002 Recent advances in the field require an update of our Wnt pathway scheme ( [Hulsken and Behrens, 2000][1]). Intracellular signaling of the Wnt pathway diversifies into at least three branches: (1) the β-catenin pathway (canonical Wnt pathway, blue), which activates target genes in the nucleus ...
Joerg, Huelsken, Juergen, Behrens
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Genes and DiseasesThe evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non ...
Michael Yu +18 more
doaj +1 more source
Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence
Frontiers in Cell and Developmental Biology, 2020 WNT signaling is crucial for tissue morphogenesis during development in all multicellular animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue homeostasis in various organs and hyperactive WNT/CTNNB1 signaling is observed in ...
Emma H. van Schie, Renée van Amerongen
doaj +1 more source
LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. [PDF]
, 2015 PurposeLeucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a cancer stem cell marker and a down-stream target in Wnt/β-catenin signaling. In human papillary thyroid cancer (PTC), over activation of Wnt/β-catenin has been associated with
Diehl, Anna Mae +4 more
core +3 more sources
Cold Spring Harbor Perspectives in Biology, 2012 Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. From the earliest observation that Wnt overexpression could lead to malignant transformation of mouse mammary tissue to the most recent genetic discoveries gleaned from tumor genome sequencing, the Wnt pathway continues to evolve as a central mechanism in cancer ...
openaire +2 more sources