Results 101 to 110 of about 1,133,912 (305)

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Corrigendum: Physical Activity as a Preventive Lifestyle Intervention Acts Through Specific Exosomal miRNA Species—Evidence From Human Short- and Long-Term Pilot Studies

Frontiers in Physiology, 2021
Kitti Garai, Kitti Garai, Zoltan Adam, Zoltan Adam, Robert Herczeg, Krisztina Banfai, Krisztina Banfai, Adam Gyebrovszki, Attila Gyenesei, Judit E. Pongracz, Judit E. Pongracz, Marta Wilhelm, Krisztian Kvell, Krisztian Kvell   +13 more
doaj   +1 more source

WNT signaling in cancer: molecular mechanisms and potential therapies

Molecular Biomedicine
The WNT signaling pathway, a fundamental molecular network regulating cell proliferation, differentiation, and stemness, plays a critical role in tumorigenesis, cancer progression, and therapeutic resistance. Given its crucial regulatory roles in tumors,
Jiaqi Liang, Yiming Pan, Jingru Yang, Dequan Zeng, Jing Li   +4 more
doaj   +1 more source

Wnt signaling is required for early development of zebrafish swimbladder.

PLoS ONE, 2011
BackgroundWnt signaling plays critical roles in mammalian lung development. However, Wnt signaling in the development of the zebrafish swimbladder, which is considered as a counterpart of mammalian lungs, have not been explored.
Ao Yin, Svitlana Korzh, Cecilia L Winata, Vladimir Korzh, Zhiyuan Gong   +4 more
doaj   +1 more source

Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells

, 2015
Indexación: ScopusChromosomal translocations are frequently associated with a wide variety of cancers, particularly hematologic malignancies. A recurrent chromosomal abnormality in acute myeloid leukemia is the reciprocal translocation t(8;21) that fuses
Elorza, Alvaro A., Vargas, Macarena F., Moon, Randall T., Loyola, Alejandra, Medina, Matías A., Gutiérrez, Soraya E., Ugarte, Giorgia D., León, Pablo, Necuñir, David, De Ferrari, Giancarlo V.   +9 more
core   +1 more source

Wnt signaling and polarity in freshwater sponges [PDF]

, 2018
Background: The Wnt signaling pathway is uniquely metazoan and used in many processes during development, including the formation of polarity and body axes.
Posfai, Dora, Hill, April L., Leys, Sally P., Matveev, Eugueni, McClymont, Alexandra, Windsor Reid, Pamela J.   +5 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

WNT signaling – lung cancer is no exception

Respiratory Research, 2017
Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the complex roles for WNT signaling pathways in lung cancers has increased substantially. In the current review, the various effects of activation and inhibition of
Judit Rapp, Luca Jaromi, Krisztian Kvell, Gyorgy Miskei, Judit E. Pongracz   +4 more
doaj   +1 more source

The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention

, 2021
The WNT pathway is one of the major signaling cascades frequently deregulated in human cancer. While research had initially focused on signal transduction centered on β-catenin as a key effector activating a pro-tumorigenic transcriptional response ...
Bleckmann, Annalen, Cornelia Baden, Annalen Bleckmann, Baden, Cornelia, Saskia Heinrichs, Heinrichs, Saskia, Kerstin Menck, Menck, Kerstin   +7 more
core   +1 more source