Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. [PDF]
PLoS ONE, 2014 OBJECTIVE:According to the current hypothesis, tumor-associated macrophages (TAMs) are "corrupted" by cancer cells and subsequently facilitate, rather than inhibit, tumor metastasis.
Magdalena Król +13 more
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Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. [PDF]
PLoS ONE, 2014 The characterization of mammary stem cells, and signals that regulate their behavior, is of central importance in understanding developmental changes in the mammary gland and possibly for targeting stem-like cells in breast cancer.
Alexander M Many, Anthony M C Brown
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Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers
Frontiers in Oncology, 2019 Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the formation and development of cancer cells. It plays a central role in three cyclic processes, which are the cell division cycle, the immune cycle, and circadian ...
Alexandre Vallée +2 more
exaly +3 more sources
Canonical Wnt signaling regulates Mbd3 protein stability during neurogenesis [PDF]
Experimental and Molecular MedicineAcquisition of neural progenitor cell (NPC) homeostasis through balancing self-renewal and differentiation is essential for brain development and function.
Nhu Thi Quynh Mai +2 more
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Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Ovarian cancer is a malignant tumor of the female reproductive system with the highest mortality, and involves the aberrant regulation of multiple molecular signaling pathways.
ZHOU Wanzhen, TENG Yincheng
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Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. [PDF]
PLoS ONE, 2015 WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner.
Michaela Bayerlová +5 more
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Ligand-independent canonical Wnt activity in canine mammary tumor cell lines associated with aberrant LEF1 expression. [PDF]
PLoS ONE, 2014 Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechanisms during canine mammary tumorigenesis, in this study
Ana Gracanin +7 more
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Premise and peril of Wnt signaling activation through GSK-3β inhibition
iScience, 2022 Summary: Wnt signaling pathways have been extensively studied in the context of several diseases, including cancer, coronary artery disease, and age-related disorders.
Samuel M. Law, Jie J. Zheng
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Disease Models & Mechanisms, 2011 SUMMARY Despite available therapies, myocardial infarction (MI) remains a leading cause of death worldwide. Better understanding of the molecular and cellular mechanisms that regulate cardiac repair should help to improve the clinical outcome of MI ...
Omonigho Aisagbonhi +5 more
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Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells
Molecular Cancer, 2009 Background β-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs).
Yilmaz Mustafa +11 more
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