Results 21 to 30 of about 75,163 (297)

The structural biology of canonical Wnt signalling [PDF]

Biochemical Society Transactions, 2020
The Wnt signalling pathways are of great importance in embryonic development and oncogenesis. Canonical and non-canonical Wnt signalling pathways are known, with the canonical (or β-catenin dependent) pathway being perhaps the best studied of these.
Mark Agostino, Sebastian Öther-Gee Pohl
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Canonical and Non-Canonical Wnt Signaling in Immune Cells [PDF]

Trends in Immunology, 2018
Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear.
Wook-Jin, Chae, Alfred L M, Bothwell
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Canonical Wnt Signaling Sets the Pace [PDF]

Developmental Cell, 2019
In this issue of Developmental Cell, Ren et al. (2019) identify the embryonic origin of cardiac pacemaker cells in zebrafish and implicate Wnt5b in promoting their differentiation. Furthermore, canonical Wnt activation in human stem cell-derived cardiac progenitors produces functional pacemaker cells in vitro, advancing the therapeutic potential of ...
C Geoffrey, Burns, Caroline E, Burns
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Canonical Wnt signaling in systemic sclerosis [PDF]

Laboratory Investigation, 2016
Fibrosing disorders are characterized by abundant accumulation of extracellular matrix proteins such as collagen in a variety of organs, which results in structural changes and dysfunction of the affected organ. Thus fibrotic diseases are characterized by a high morbidity and mortality and also lead to major socioeconomic costs. Systemic sclerosis (SSc)
Christina, Bergmann, Jörg H W, Distler
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Loss of FTO Antagonises Wnt Signaling and Leads to Developmental Defects Associated with Ciliopathies [PDF]

, 2014
Common intronic variants in the Human fat mass and obesity-associated gene (FTO) are found to be associated with an increased risk of obesity. Overexpression of FTO correlates with increased food intake and obesity, whilst loss-of-function results in ...
Rosa Maria Roccasecca (519728), Osborn Daniel P. S., Beales, PL, Daniel P. S. Osborn (519727), Fiona McMurray, Derek Stemple (183414), McMurray, F, Stemple Derek, Roccasecca, RM, Barroso, I, Philip L. Beales (492737), Osborn, DP, Inês Barroso (2144), Hernandez-Hernandez, V, Mukherjee, S, Derek Stemple, Cox, R, Philip L Beales, Victor Hernandez-Hernandez, Stemple, D, Sonia Christou-Savina (519731), Christou-Savina, S, Barroso Inês, Sriparna Mukherjee, Mukherjee Sriparna, Roccasecca Rosa Maria, Cox Roger, Sonia Christou-Savina, Hernandez-Hernandez Victor, Victor Hernandez-Hernandez (519729), Fiona McMurray (106290), Rosa Maria Roccasecca, Sriparna Mukherjee (519730), Beales Philip L., Daniel P S Osborn, Inês Barroso, McMurray Fiona, Osborn, DPS, Roger Cox, Christou-Savina Sonia, Roger Cox (73899)   +40 more
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THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA [PDF]

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 2019
It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis.To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma.The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1 ...
OLIVEIRA, Levindo Alves de, OSHIMA, Celina Tizuko Fujiyama, SOFFNER, Pedro Augusto, SILVA, Marcelo de Souza, LINS, Rodrigo Rego, MALINVERNI, Andréa Cristina de Moraes, WAISBERG, Jaques   +6 more
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The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. [PDF]

, 2015
Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes.
Daniel J. Jagger, Zakia A. Abdelhamed, Johnson, CA, Carmel Toomes, Jagger, DJ, Johnson, Colin A., Toomes, C, Wheway, G, Christopher F. Inglehearn, Colin A. Johnson, Jagger, Daniel J., Toomes, Carmel, Abdelhamed, ZA, Abdelhamed, Zakia A., Subaashini Natarajan, Inglehearn, CF, Natarajan, Subaashini, Gabrielle Wheway, Inglehearn, Christopher F., Natarajan, S, Inglehearn, Chris F., Wheway, Gabrielle   +21 more
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Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]

, 2014
In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier, Fischer, Bruno,, Sommer, Lukas, Sommer, Lukas,, Draganova, Kalina,, Draganova, Kalina, Fischer, Bruno, Cantu, Claudio, Azim, Kasum,, Butt, Arthur, Raineteau, Olivier,, Butt, Arthur,, Azim, Kasum, Hurtado-Chong, Anahi,, Hurtado-Chong, Anahi, Cantù, Claudio,, Zemke, Martina, Zemke, Martina,   +17 more
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Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways [PDF]

, 2011
WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four ...
Marisa Karow,, Faussner, Alexander, Neth, Peter, Alexander Faussner,, Larisa Ring,, Alexander Faussner, Peter Neth,, Karow, Marisa, Marianne Jochum,, Iris Peröbner,, Marisa Karow, Marianne Jochum, Iris Peröbner, Peroebner, Iris, Jochum, Marianne, Larisa Ring, Ring, Larisa, Peter Neth   +17 more
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PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling [PDF]

The EMBO Journal, 2011
Wnt signalling is an evolutionarily conserved pathway that directs cell-fate determination and morphogenesis during metazoan development. Wnt ligands are secreted glycoproteins that act at a distance causing a wide range of cellular responses from stem cell maintenance to cell death and cell proliferation. How Wnt ligands cause such disparate responses
Peradziryi, Hanna, Kaplan, Nicole A., Podleschny, Martina, Liu, Xiaoping, Wehner, Peter, Borchers, Annette, Tolwinski, Nicholas S.   +6 more
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