Results 21 to 30 of about 358,972 (247)

Reporter gene HEK 293 cells and WNT/Frizzled fusion proteins as tools to study WNT signaling pathways [PDF]

, 2011
WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological processes. In humans, the complexity of WNT/FZD signaling is based on 19 WNTs, 10 FZDs and at least two (co)receptors (LRP5/6) mediating supposably four ...
Marisa Karow,, Faussner, Alexander, Neth, Peter, Alexander Faussner,, Larisa Ring,, Alexander Faussner, Peter Neth,, Karow, Marisa, Marianne Jochum,, Iris Peröbner,, Marisa Karow, Marianne Jochum, Iris Peröbner, Peroebner, Iris, Jochum, Marianne, Larisa Ring, Ring, Larisa, Peter Neth   +17 more
core   +1 more source

Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.

PLoS ONE, 2015
The Wnt system is highly complex and is comprised of canonical and non-canonical pathways leading to the activation of gene expression. Our aim was to examine changes in the expression of Wnt ligands and regulators during hepatic stellate cell (HSC ...
Laura Corbett, Jelena Mann, Derek A Mann
doaj   +1 more source

Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer

Molecular Cancer, 2010
Background Wnt factors control cell differentiation through semi-independent molecular cascades known as the β-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways.
López-Otín Carlos, Muñoz Alberto, Astudillo Aurora, Sánchez Laura, González-Sancho José, Aguilera Oscar, Obaya Álvaro J, Moncada-Pazos Ángela, Fernández Agustin F, Huidobro Covadonga, Calvanese Vincenzo, Lara Ester, Esteller Manel, Fraga Mario F   +13 more
doaj   +1 more source

Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors. [PDF]

PLoS ONE, 2013
IntroductionCanonical and non-canonical Wnt pathways are involved in the genesis of multiple tumors; however, their role in pituitary tumorigenesis is mostly unknown.ObjectiveThis study evaluated gene and protein expression of Wnt pathways in pituitary ...
Leandro Machado Colli, Fabiano Saggioro, Luciano Neder Serafini, Renata Costa Camargo, Helio Rubens Machado, Ayrton Custodio Moreira, Sonir R Antonini, Margaret de Castro   +7 more
doaj   +1 more source

Role of Wnt canonical pathway in hematological malignancies

Journal of Hematology & Oncology, 2010
Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt/β-catenin signaling pathway is involved in the pathogenesis of many carcinomas.
Wang Xin, GE Xueling
doaj   +1 more source

Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease

Frontiers in Cell and Developmental Biology, 2020
Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dentate ...
Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Muriel D. Mardones, Lorena Varela-Nallar   +3 more
doaj   +1 more source

Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. [PDF]

PLoS ONE, 2009
Sonic hedgehog (Shh) signaling in the mouse requires the microtubule-based organelle, the primary cilium. The primary cilium is assembled and maintained through the process of intraflagellar transport (IFT) and the response to Shh is blocked in mouse ...
Polloneal Jymmiel R Ocbina, Miquel Tuson, Kathryn V Anderson   +2 more
doaj   +1 more source

Canonical Wnt Signaling Protects Hippocampal Neurons from Aβ Oligomers: Role of Non-Canonical Wnt-5a/Ca2+ in Mitochondrial Dynamics

Frontiers in Cellular Neuroscience, 2013
Alzheimer´s disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss and mitochondrial dysfunction.
Carmen eSilva-Alvarez, Macarena eArrazola, Juan A Godoy, Daniela eOrdenes, Nibaldo C. Inestrosa, Nibaldo C. Inestrosa   +5 more
doaj   +1 more source

Augmenting endogenous wnt signaling improves skin wound healing [PDF]

, 2013
Wnt signaling is required for both the development and homeostasis of the skin, yet its contribution to skin wound repair remains controversial. By employing Axin2(LacZ/+) reporter mice we evaluated the spatial and temporal distribution patterns of Wnt ...
Manzano Wilfred R., Fang Mark Y., Girija R Dhamdhere, Anthony E. Oro, Bo Liu, Fang, Mark Y, Whyte, Jemima L., Helms Jill A., Wilfred R. Manzano, Nick D. Evans (474290), Manzano, Wilfred R, Howard Y. Chang (215450), Smith, Andrew A, Manzano, Wilfred R., Whyte, Jemima L, Jemima L. Whyte (474287), Nick D Evans, Helms, Jill A., Andrew A Smith, Anthony E Oro, Andrew A. Smith (474288), Oro Anthony E., Chang, Howard Y., Jemima L Whyte, Liu Bo, Howard Y Chang, Dhamdhere, Girija R, Evans Nick D., Evans, Nick D., Wilfred R. Manzano (474289), Oro, Anthony E., Nick D. Evans¤a, Smith Andrew A., Whyte Jemima L., Liu, Bo, Mark Y. Fang (474292), Wilfred R Manzano, Jill A. Helms (25398), Fang, Mark Y., Smith, Andrew A., Andrew A. Smith, Evans, Nick D, Helms, Jill A, Girija R. Dhamdhere (474291), Girija R. Dhamdhere, Jill A Helms, Mark Y. Fang¤b, Anthony E. Oro (474293), Jill A. Helms, Dhamdhere, Girija R., Mark Y Fang, Chang, Howard Y, Chang Howard Y., Jemima L. Whyte, Oro, Anthony E, Howard Y. Chang, Bo Liu (127343), Dhamdhere Girija R.   +57 more
core   +2 more sources

The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism.

PLoS Genetics, 2018
Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration.
Remco A Mentink, Lorenzo Rella, Tomasz W Radaszkiewicz, Tomáš Gybel, Marco C Betist, Vitězslav Bryja, Hendrik C Korswagen   +6 more
doaj   +1 more source