Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer
Molecular Cancer, 2010 Background Wnt factors control cell differentiation through semi-independent molecular cascades known as the β-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways.
López-Otín Carlos +13 more
doaj +1 more source
Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors. [PDF]
PLoS ONE, 2013 IntroductionCanonical and non-canonical Wnt pathways are involved in the genesis of multiple tumors; however, their role in pituitary tumorigenesis is mostly unknown.ObjectiveThis study evaluated gene and protein expression of Wnt pathways in pituitary ...
Leandro Machado Colli +7 more
doaj +1 more source
Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Ruiz-Heinrich, Lourdes +18 more
core +1 more source
An Overview of Potential Therapeutic Agents Targeting WNT/PCP Signaling [PDF]
, 2021 Since the discovery of the proto-oncogene Wnt1 (Int1) in 1982, WNT signaling has been identified as one of the most important pathways that regulates a wide range of fundamental developmental and physiological processes in multicellular organisms.
Jin Wang +5 more
core +1 more source
Dissecting the roles of WNT signaling in breast cancer using "in vitro" and "in vivo" experimental models [PDF]
, 2009 Canonical WNT pathway regulates expression of target genes by modulating intracellular amount of β-catenin. Without WNT pathway activation, a so-called “destruction complex” including APC and Axin facilitates the degradation of β-catenin. Upon binding of
Matsuda, Yutaka
core +1 more source
Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease
Frontiers in Cell and Developmental Biology, 2020 Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into functional dentate ...
Sebastian B. Arredondo +3 more
doaj +1 more source
Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. [PDF]
PLoS ONE, 2009 Sonic hedgehog (Shh) signaling in the mouse requires the microtubule-based organelle, the primary cilium. The primary cilium is assembled and maintained through the process of intraflagellar transport (IFT) and the response to Shh is blocked in mouse ...
Polloneal Jymmiel R Ocbina +2 more
doaj +1 more source
PLoS Genetics, 2018 Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration.
Remco A Mentink +6 more
doaj +1 more source
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi +29 more
core +1 more source
Functional Consequences of Wnt-induced Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling [PDF]
Journal of Biological Chemistry, 2013 Dishevelled (Dvl) proteins are intracellular effectors of Wnt signaling that have essential roles in both canonical and noncanonical Wnt pathways. It has long been known that Wnts stimulate Dvl phosphorylation, but relatively little is known about its functional significance.
González Sancho, José Manuel +8 more
openaire +3 more sources